Structural basis for RanGTP independent entry of spliceosomal U snRNPs into the nucleus
Journal of Molecular Biology, 2007 The nuclear import of assembled spliceosomal subunits, the uridine rich small nuclear ribonucleoprotein particles U snRNPs , is mediated by a nuclear import receptor adaptor couple of importin amp; 946; Imp amp; 946; and snurportin1 SPN1 .
Ficner, Ralf +7 more
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The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes. [PDF]
PLoS ONE, 2015 The inner nuclear membrane (INM) protein Nemp1/TMEM194A has previously been suggested to be involved in eye development in Xenopus, and contains two evolutionarily conserved sequences in the transmembrane domains (TMs) and the C-terminal region, named ...
Takashi Shibano +4 more
doaj +2 more sources
Role of RanGTP and spindle assembly factors in cilia assembly and function [PDF]
, 2021 El cilio primario es una estructura formada por microtúbulos que sobresale de la superficie celular durante G0 teniendo una función de orgánulo sensor.
Mòdol Cano, Aitor
core +3 more sources
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open BioBMI‐1 (B‐cell‐specific Moloney murine leukemia virus integration site 1) has been implicated in both normal and cancer cell biology. While the canonical function of BMI‐1 involves epigenetic repression, novel extranuclear functions have been recently ...
Banlanjo Umaru +6 more
doaj +2 more sources
Localized RanGTP accumulation promotes microtubule nucleation at kinetochores in somatic mammalian cells [PDF]
Molecular Biology of the Cell, 2008 Centrosomes are the major sites for microtubule nucleation in mammalian cells, although both chromatin- and kinetochore- mediated microtubule nucleation have been observed during spindle assembly.
Lavia P +4 more
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CHD4 Is a RanGTP-Dependent MAP that Stabilizes Microtubules and Regulates Bipolar Spindle Formation [PDF]
Current Biology, 2013 peer reviewedBackground Production of the GTP-bound form of the Ran GTPase (RanGTP) around chromosomes induces spindle assembly by activating nuclear localization signal (NLS)-containing proteins.
Krijgsveld, Jeroen +7 more
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NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement
Advanced SciencePrecise centrosome regulation is crucial for faithful cell division, yet how microtubule‐associated proteins (MAPs) contribute to centrosome integrity remains poorly understood.
Shiyu Zhang +8 more
doaj +2 more sources
Using FRET to Study RanGTP Gradients in Live Mouse Oocytes.
, 2012 International audienceOocytes are extremely large cells that have to coordinate accurate chromosome segregation, asymmetric cytoplasm partitioning together with their own development as fertilizable gametes. For this, they undergo both global (cell cycle
Dumont, Julien +3 more
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Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP.
Science, 2009 CRM1 mediates nuclear export of numerous unrelated cargoes, which may carry a short leucine rich nuclear export signal or export signatures that include folded domains. How CRM1 recognizes such a variety of cargoes has been unknown up to this point. Here
Monecke, T. +11 more
core +6 more sources
Induced opening of conformational switch I in GTP-bound Ran GTPase. [PDF]
Protein SciAbstract Ran is a small GTPase that regulates nucleocytoplasmic transport by cycling between an inactive GDP‐bound and active GTP‐bound state. Structurally, Ran consists of a globular G‐domain and a C‐terminal region that includes a C‐terminal helix. The switch I and II regions of the G‐domain undergo major conformational changes upon GTP hydrolysis ...
Czigleczki J, Dudas B, Balog E.
europepmc +2 more sources