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β-tubulin phosphorylation by Chk1 is required for normal spindle formation during cell division [PDF]
Communications BiologyThe mitotic spindle is a microtubule-based apparatus that is responsible for accurate segregation of chromosomes into two daughter cells. In this study, we show that the DNA damage kinase Chk1 is required for optimal density and efficient nucleation of ...
Nikos Boutakoglou +7 more
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ASSOCIATION BETWEEN THE SPINDLE APPARATUS AND REOVIRUS [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1963 Samuel Dales, Dales Samuel
exaly +3 more sources
Rare Antinuclear Antibody Patterns: Relevance in Routine Laboratory Reporting [PDF]
Journal of Clinical and Diagnostic Research, 2023 Introduction: Uncommon patterns on Human Epithelial 2 (Hep 2) substrate during Antinuclear Antibody (ANA) screening by Indirect Immunofluorescence (IIF) microscopy are not routinely reported by many laboratories since their clinical relevance is not well
Vidya Bhakta
doaj +1 more source
Genetic Disorders Affecting Tubulin Cytoskeleton [PDF]
Journal of Biomedical & Clinical Research, 2015 The tubulin cytoskeleton is vital for maintenance and dynamics of eukaryotic cells and molecular defects in its components can lead to serious conditions.
Maya Markova +5 more
doaj +3 more sources
A Balance between Nuclear and Cytoplasmic Volumes Controls Spindle Length. [PDF]
PLoS ONE, 2016 Proper assembly of the spindle apparatus is crucially important for faithful chromosome segregation during anaphase. Thanks to the effort over the last decades, we have very detailed information about many events leading to spindle assembly and ...
Lucia Novakova +5 more
doaj +1 more source
USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation. [PDF]
PLoS ONE, 2018 Correct segregation of the mitotic chromosomes into daughter cells is a highly regulated process critical to safeguard genome stability. During M phase the spindle assembly checkpoint (SAC) ensures that all kinetochores are correctly attached before its ...
Anna Stockum +2 more
doaj +1 more source
Cell Division, 2021 Background Ral family is a member of Ras-like GTPase superfamily, which includes RalA and RalB. RalA/B play important roles in many cell biological functions, including cytoskeleton dynamics, cell division, membrane transport, gene expression and signal ...
Ming-Hong Sun +7 more
doaj +1 more source
The association between muscle architecture and muscle spindle abundance
Scientific Reports, 2023 Across the human body, skeletal muscles have a broad range of biomechanical roles that employ complex proprioceptive control strategies to successfully execute a desired movement.
Roger W. P. Kissane +3 more
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The centrosome and mitotic spindle apparatus in cancer and senescence [PDF]
Cell Cycle, 2010 Altered cell division is associated with overproliferation and tumorigenesis, however, mitotic aberrations can also trigger antiproliferative responses leading to postmitotic cell cycle exit. Here, we focus on the role of the centrosome and in particular of centrosomal TACC (transforming acidic coiled coil) proteins in tumorigenesis and cellular ...
Stephen, Schmidt +13 more
openaire +2 more sources
Mechanisms of spindle bipolarity establishment in acentrosomal human cells
Molecular & Cellular Oncology, 2020 Centrosomes are not absolutely essential for cell division; acentrosomal bipolar spindles can be established in oocytes and centrosome-eliminated somatic cells.
Kaho Hashimoto +2 more
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