CKAP2 ensures chromosomal stability by maintaining the integrity of microtubule nucleation sites. [PDF]
PLoS ONE, 2013 Integrity of the microtubule spindle apparatus and intact cell division checkpoints are essential to ensure the fidelity of distributing chromosomes into daughter cells.
Chanelle M Case +6 more
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Aflatoxin B1 exposure disrupts organelle distribution in mouse oocytes [PDF]
PeerJ, 2022 Aflatoxin B1 (AFB1) is a secondary metabolite produced by the fungus Aspergillus, which is ubiquitous in moldy grain products. Aflatoxin B1 has been reported to possess hepatotoxicity, renal toxicity, and reproductive toxicity.
Yan-Zhe Zhang +5 more
doaj +2 more sources
Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A [PDF]
, 2013 Anaphase central spindle formation is controlled by the microtubule-stabilizing factor PRC1 and the kinesin KIF4A. We show that an MKlp2-dependent pool of Aurora B at the central spindle, rather than global Aurora B activity, regulates KIF4A accumulation
Erich A. Nigg +16 more
core +1 more source
Morphogenetic forces planar polarize LGN/Pins in the embryonic head during Drosophila gastrulation
eLife, 2022 Spindle orientation is often achieved by a complex of Partner of Inscuteable (Pins)/LGN, Mushroom Body Defect (Mud)/Nuclear Mitotic Apparatus (NuMa), Gαi, and Dynein, which interacts with astral microtubules to rotate the spindle.
Jaclyn Camuglia +2 more
doaj +1 more source
Autoantibodies to the mitotic spindle apparatus in Mycoplasma pneumoniae disease [PDF]
Infection and Immunity, 1988 Antibodies to the mitotic spindle apparatus (MS) have been detected in only a very few patient sera studied for antinuclear antibodies by routine screening (G. A. McCarty, D. W. Velencia, and M. J. Fritzler, J. Rheumatol. 11:213-218, 1984). We found anti-MS antibodies to be quite common in sera from patients with Mycoplasma pneumoniae, especially in ...
K, Lind, M, Høier-Madsen, A, Wiik
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Latrunculin A delays anaphase onset in fission yeast by disrupting an ase1-independent pathway controlling mitotic spindle stability [PDF]
, 2008 It has been proposed previously that latrunculin A, an inhibitor of actin polymerization, delays the onset of anaphase by causing spindle misorientation in fission yeast.
Meadows, John C., Millar, Jonathan B. A.
core +1 more source
A regulatory effect of INMAP on centromere proteins: antisense INMAP induces CENP-B variation and centromeric halo. [PDF]
PLoS ONE, 2014 CENP-B is a highly conserved protein that facilitates the assembly of specific centromere structures both in interphase nuclei and on mitotic chromosomes. INMAP is a conserved protein that localizes at nucleus in interphase cells and at mitotic apparatus
Tan Tan +4 more
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Chatter Control by Spindle Speed Variation in High-Speed Milling [PDF]
, 2009 High-speed milling operations are often limited by regenerative vibrations. The aim of this paper is to analyze the effect of spindle speed variation on machine tool chatter in high-speed milling. The stability analysis of triangular and sinusoidal shape
Arnaud, Lionel +3 more
core +1 more source
Spindle birefringence of isolated mitotic apparatus: further evidence for two birefringent spindle components [PDF]
Journal of Cell Science, 1976 ABSTRACT We studied sea-urchin zygote mitotic apparatus (MA) isolated in hexylene glycol, transferred immediately to a glycerol-dimethylsulphoxide medium, and stored for 2 weeks at room temperature. Treatment with 0·5 M KC1 caused loss of 45% of the birefringence, but microtubules remained intact (as seen electron microscopically in ...
A, Forer, V I, Kalnins, A M, Zimmerman
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On the stability of high-speed milling with spindle speed variation [PDF]
, 2010 Spindle speed variation is a well-known technique to suppress regenerative machine tool vibrations, but it is usually considered to be effective only for low spindle speeds.
Arnaud, Lionel +4 more
core +1 more source