Rational Choice of Machining Tools Using Prediction Procedures [PDF]
, 2018 Introducing the methods and procedures for predictive analysis into the design process contours of a variety of machining tools (MT) of metal cutting machines is the main aim of this article.
Krol, O. (Oleg), Sokolov, V. (Volodymyr)
core +2 more sources
Evolutionary cell biology of chromosome segregation: insights from trypanosomes [PDF]
Open Biology, 2013 Faithful transmission of genetic material is essential for the survival of all organisms. Eukaryotic chromosome segregation is driven by the kinetochore that assembles onto centromeric DNA to capture spindle microtubules and govern the movement of ...
Bungo Akiyoshi, Keith Gull
doaj +1 more source
Phenotypic evolution in microalgae: a dramatic morphological shift in Dictyosphaerium chlorelloides (Chlorophyta) after exposure to TNT [PDF]
, 2006 Phenotypic evolution in microalgae: a dramatic morphological shift in Dictyosphaerium chlorelloides (Chlorophyta) after exposure to TNT. The occurrence of rapid morphological evolution in the microalga Dictyosphaerium chlorelloides (Chlorophyta) was ...
Costas, Eduardo +3 more
core +3 more sources
iScience, 2021 Summary: Here we identify human Kinesin-5, Kif11/HsEg5, as a cellular target of Zika protease. We show that Zika NS2B-NS3 protease targets several sites within the motor domain of HsEg5 irrespective of motor binding to microtubules.
Liqiong Liu +3 more
doaj +1 more source
Evidence for a role of spindle matrix formation in cell cycle progression by antibody perturbation.
PLoS ONE, 2018 In Drosophila it has recently been demonstrated that a spindle matrix in the form of a membrane-less macromolecular assembly embeds the microtubule-based spindle apparatus.
Changfu Yao +7 more
doaj +1 more source
Natural products as new antimitotic compounds for anticancer drug development
Clinics, 2018 Cell cycle control genes are frequently mutated in cancer cells, which usually display higher rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability, which contributes to tumor progression and aggressiveness.
Carlos Roberto Koscky Paier +8 more
doaj +1 more source
Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium
Cells, 2021 Aberrant centrosome activities in mutants of Dictyostelium discoideum result in anomalies of mitotic spindles that affect the reliability of chromosome segregation.
Mary Ecke +2 more
doaj +1 more source
Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules [PDF]
, 2017 Tubulin-targeting molecules are widely used cancer therapeutic agents. They inhibit microtubule-based structures, including the mitotic spindle, ultimately preventing cell division.
Coluccia, Antonio +10 more
core +1 more source
Biology Open, 2013 Summary In animal cells the centrosome is commonly viewed as the main cellular structure driving microtubule (MT) assembly into the mitotic spindle apparatus.
Nicolas Lecland +10 more
doaj +1 more source
Arp2/3 complex regulates asymmetric division and cytokinesis in mouse oocytes. [PDF]
PLoS ONE, 2011 Mammalian oocyte meiotic maturation involves oocyte polarization and a unique asymmetric division, but until now, the underlying mechanisms have been poorly understood.
Shao-Chen Sun +5 more
doaj +1 more source