Results 51 to 60 of about 26,039 (180)

Evidence for a role of spindle matrix formation in cell cycle progression by antibody perturbation.

PLoS ONE, 2018
In Drosophila it has recently been demonstrated that a spindle matrix in the form of a membrane-less macromolecular assembly embeds the microtubule-based spindle apparatus.
Changfu Yao, Chao Wang, Yeran Li, Michael Zavortink, Vincent Archambault, Jack Girton, Kristen M Johansen, Jørgen Johansen   +7 more
doaj   +1 more source

Natural products as new antimitotic compounds for anticancer drug development

Clinics, 2018
Cell cycle control genes are frequently mutated in cancer cells, which usually display higher rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability, which contributes to tumor progression and aggressiveness.
Carlos Roberto Koscky Paier, Sarah Sant’Anna Maranhão, Teiliane Rodrigues Carneiro, Lídia Moreira Lima, Danilo Damasceno Rocha, Renan da Silva Santos, Kaio Moraes de Farias, Manoel Odorico de Moraes-Filho, Claudia Pessoa   +8 more
doaj   +1 more source

Inter-organelle interactions between the ER and mitotic spindle facilitates Zika protease cleavage of human Kinesin-5 and results in mitotic defects

iScience, 2021
Summary: Here we identify human Kinesin-5, Kif11/HsEg5, as a cellular target of Zika protease. We show that Zika NS2B-NS3 protease targets several sites within the motor domain of HsEg5 irrespective of motor binding to microtubules.
Liqiong Liu, Micquel Downs, Jesse Guidry, Edward J. Wojcik   +3 more
doaj   +1 more source

Investigating the cellular and molecular mechanisms involved in establishing and maintaining centrosome asymmetry in Drosophila neuroblasts [PDF]

, 2015
Centrosome asymmetry has been implicated in stem cell fate maintenance in both flies and vertebrates. Drosophila neuroblasts, the neural precursors of the fly’s central nervous system, contain molecularly and physically asymmetric centrosomes.
Nair, Anjana Ramdas
core   +1 more source

Mechanism of spindle pole organization and instability in human oocytes [PDF]

, 2022
Human oocytes are prone to assembling meiotic spindles with unstable poles, which can favor aneuploidy in human eggs. The underlying causes of spindle instability are unknown.
So, Chun, Harasimov, Katarina, Moltrecht, Rüdiger, Steyer, A., Steyer, Anna M., Eckel, H., Möbius, W., Lukinavičius, Gražvydas, Moltrecht, R., Tandler-Schneider, Andreas, Elder, Kay, Harasimov, K., Tandler-Schneider, A., Uraji, J., Menelaou, K., Bucevičius, Jonas, Blayney, M., Sibold, Claus, So, C., Möbius, Wiebke, Eckel, Heike, Seres, K., Lukinavicius, G., Schuh, M. ; https://orcid.org/, Uraji, Julia, Menelaou, Katerina, Schuh, Melina, Sibold, C., Elder, K., Bucevičius, J., Blayney, Martyn, Seres, K. Bianka   +31 more
core   +1 more source

Establishment and mitotic characterization of new Drosophila acentriolar cell lines from DSas-4 mutant

Biology Open, 2013
Summary In animal cells the centrosome is commonly viewed as the main cellular structure driving microtubule (MT) assembly into the mitotic spindle apparatus.
Nicolas Lecland, Alain Debec, Audrey Delmas, Sara Moutinho-Pereira, Nicolas Malmanche, Anais Bouissou, Clémence Dupré, Aimie Jourdan, Brigitte Raynaud-Messina, Helder Maiato, Antoine Guichet   +10 more
doaj   +1 more source

Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium

Cells, 2021
Aberrant centrosome activities in mutants of Dictyostelium discoideum result in anomalies of mitotic spindles that affect the reliability of chromosome segregation.
Mary Ecke, Jana Prassler, Günther Gerisch   +2 more
doaj   +1 more source

Arp2/3 complex regulates asymmetric division and cytokinesis in mouse oocytes. [PDF]

PLoS ONE, 2011
Mammalian oocyte meiotic maturation involves oocyte polarization and a unique asymmetric division, but until now, the underlying mechanisms have been poorly understood.
Shao-Chen Sun, Zhen-Bo Wang, Yong-Nan Xu, Seung-Eun Lee, Xiang-Shun Cui, Nam-Hyung Kim   +5 more
doaj   +1 more source

Mitotic Spindle as Therapeutic Target for Tetraploid Cancer Cells [PDF]

, 2021
Tetraploidy constitutes a genomically metastable state that drives oncogenesis by leading aneuploidy. Tetraploid sub-population is frequently found in pre-neoplastic lesions.
mohamed jemaa, Jemaà, Mohamed
core   +1 more source

Initial Characterization of two novel spindle proteins, CHICA and HURP [PDF]

, 2008
During mitotic spindle assembly, the sister chromatids have to be captured by kinetochore (K) -fibers (bundles of kinetochore microtubules; KMTs) to ensure stable attachment of the chromosomes.
Nagel, Susanna
core