Results 31 to 40 of about 25,078 (240)
Spindle birefringence of isolated mitotic apparatus: further evidence for two birefringent spindle components [PDF]
Journal of Cell Science, 1976 ABSTRACT We studied sea-urchin zygote mitotic apparatus (MA) isolated in hexylene glycol, transferred immediately to a glycerol-dimethylsulphoxide medium, and stored for 2 weeks at room temperature. Treatment with 0·5 M KC1 caused loss of 45% of the birefringence, but microtubules remained intact (as seen electron microscopically in ...
A, Forer, V I, Kalnins, A M, Zimmerman
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Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells. [PDF]
PLoS ONE, 2016 Mutations of the huntingtin protein (HTT) gene underlie both adult-onset and juvenile forms of Huntington's disease (HD). HTT modulates mitotic spindle orientation and cell fate in mouse cortical progenitors from the ventricular zone.
Carla Lopes +7 more
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Two major autoantigen—Antibody systems of the mitotic spindle apparatus [PDF]
Arthritis & Rheumatism, 1996 AbstractObjective. To characterize human autoantigen‐antibody systems related to the mitotic poles and spindles.Methods. Thirty‐seven human sera with autoantibodies staining mitotic poles and spindles in indirect immunofluorescence (IIF) studies were further characterized by immunofluorescence on mitotic cells and by immunoblotting and ...
L E, Andrade +3 more
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European Journal of Cell Biology, 2022 To understand general features in evolution of kinetochore organization, investigating a wide range of mitotic mechanisms in various non-model eukaryotes is necessary.
Pavla Tůmová +2 more
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Frontiers in Marine Science, 2021 Fertilized Zhikong scallop (Chlamys farreri) eggs were treated with cytochalasin B (CB 0.5 mg/L) at 14–15 min postfertilization to inhibit first polar body formation.
Yongren Li +3 more
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Evolutionary cell biology of chromosome segregation: insights from trypanosomes [PDF]
Open Biology, 2013 Faithful transmission of genetic material is essential for the survival of all organisms. Eukaryotic chromosome segregation is driven by the kinetochore that assembles onto centromeric DNA to capture spindle microtubules and govern the movement of ...
Bungo Akiyoshi, Keith Gull
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Microtubule and Actin Cytoskeletal Dynamics in Male Meiotic Cells of Drosophila melanogaster
Cells, 2022 Drosophila dividing spermatocytes offer a highly suitable cell system in which to investigate the coordinated reorganization of microtubule and actin cytoskeleton systems during cell division of animal cells.
Anna Frappaolo +2 more
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Manipulation of the oocyte: possible damage to the spindle apparatus
Reproductive BioMedicine Online, 2002 Oocytes are structured, polarized cells. For high developmental potential, it is essential that the distribution of organelles and molecules, and the function of meiotic spindles remain intact during handling of oocytes in assisted reproduction. Spindles are dynamic cell organelles. Spindle formation depends on activity of motor proteins, energy supply
Ursula, Eichenlaub-Ritter +2 more
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Evidence for a role of spindle matrix formation in cell cycle progression by antibody perturbation.
PLoS ONE, 2018 In Drosophila it has recently been demonstrated that a spindle matrix in the form of a membrane-less macromolecular assembly embeds the microtubule-based spindle apparatus.
Changfu Yao +7 more
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Natural products as new antimitotic compounds for anticancer drug development
Clinics, 2018 Cell cycle control genes are frequently mutated in cancer cells, which usually display higher rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability, which contributes to tumor progression and aggressiveness.
Carlos Roberto Koscky Paier +8 more
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