Results 21 to 30 of about 26,039 (180)
Genetic Disorders Affecting Tubulin Cytoskeleton [PDF]
Journal of Biomedical & Clinical Research, 2015 The tubulin cytoskeleton is vital for maintenance and dynamics of eukaryotic cells and molecular defects in its components can lead to serious conditions.
Maya Markova +5 more
doaj +3 more sources
USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation. [PDF]
PLoS ONE, 2018 Correct segregation of the mitotic chromosomes into daughter cells is a highly regulated process critical to safeguard genome stability. During M phase the spindle assembly checkpoint (SAC) ensures that all kinetochores are correctly attached before its ...
Anna Stockum +2 more
doaj +1 more source
Cell Division, 2021 Background Ral family is a member of Ras-like GTPase superfamily, which includes RalA and RalB. RalA/B play important roles in many cell biological functions, including cytoskeleton dynamics, cell division, membrane transport, gene expression and signal ...
Ming-Hong Sun +7 more
doaj +1 more source
The centrosome and mitotic spindle apparatus in cancer and senescence [PDF]
Cell Cycle, 2010 Altered cell division is associated with overproliferation and tumorigenesis, however, mitotic aberrations can also trigger antiproliferative responses leading to postmitotic cell cycle exit. Here, we focus on the role of the centrosome and in particular of centrosomal TACC (transforming acidic coiled coil) proteins in tumorigenesis and cellular ...
Stephen, Schmidt +13 more
openaire +2 more sources
Human TPX2 is required for targeting Aurora-A kinase to the spindle [PDF]
, 2002 Aurora-A is a serine-threonine kinase implicated in the assembly and maintenance of the mitotic spindle. Here we show that human Aurora-A binds to TPX2, a prominent component of the spindle apparatus.
Roman Körner +18 more
core +1 more source
The association between muscle architecture and muscle spindle abundance
Scientific Reports, 2023 Across the human body, skeletal muscles have a broad range of biomechanical roles that employ complex proprioceptive control strategies to successfully execute a desired movement.
Roger W. P. Kissane +3 more
doaj +1 more source
A newly conceived cylinder measuring machine and methods that eliminate the spindle errors [PDF]
, 2012 Advanced manufacturing processes require improving dimensional metrology applications to reach a nanometric accuracy level. Such measurements may be carried out using conventional highly accurate roundness measuring machines.
David, Jean Marie +6 more
core +1 more source
Effects of pentoxifylline on mouse oocytes maturation and qualityin vitro [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): To investigate the impact of Pentoxifylline (PTX) on the in vitro maturation (IVM) of mouse oocytes and its effect on oocyte quality.Materials and Methods: This experimental study involved culturing mouse oocytes in an IVM medium with ...
Wu Junjiao, Wu Jianbo, Yanyan Xu
doaj +1 more source
The spindle matrix protein, Chromator, is a novel tubulin binding protein that can interact with both microtubules and free tubulin. [PDF]
PLoS ONE, 2014 The chromodomain protein, Chromator, is localized to chromosomes during interphase; however, during cell division together with other nuclear proteins Chromator redistributes to form a macro molecular spindle matrix complex that embeds the microtubule ...
Changfu Yao +8 more
doaj +1 more source
A spindle-like apparatus guides bacterial chromosome segregation [PDF]
Nature Cell Biology, 2010 Until recently, a dedicated mitotic apparatus that segregates newly replicated chromosomes into daughter cells was believed to be unique to eukaryotic cells. Here we demonstrate that the bacterium Caulobacter crescentus segregates its chromosome using a partitioning (Par) apparatus that has surprising similarities to eukaryotic spindles.
Jerod L, Ptacin +7 more
openaire +2 more sources