Results 21 to 30 of about 402,652 (266)
A nuclear-derived proteinaceous matrix embeds the microtubule spindle apparatus during mitosis
Molecular Biology of the Cell, 2012 The concept of a spindle matrix has long been proposed. Whether such a structure exists, however, and what its molecular and structural composition are have remained controversial. In this study, using a live-imaging approach in Drosophila syncytial embryos, we demonstrate that nuclear proteins reorganize during mitosis to form a highly dynamic ...
Helder Maiato +2 more
exaly +4 more sources
Rare Antinuclear Antibody Patterns: Relevance in Routine Laboratory Reporting [PDF]
Journal of Clinical and Diagnostic Research, 2023 Introduction: Uncommon patterns on Human Epithelial 2 (Hep 2) substrate during Antinuclear Antibody (ANA) screening by Indirect Immunofluorescence (IIF) microscopy are not routinely reported by many laboratories since their clinical relevance is not well
Vidya Bhakta
doaj +1 more source
The muntjac spindle staining assay: An investigation of the ability of this assay to detect potential aneuploidy inducing agents [PDF]
, 1988 This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel University.An assay using muntjac fibroblasts in conjunction with a differential spindle and chromosome stain was developed and evaluated for its ability to detect ...
Pascoe, Sally Ann
core +7 more sources
Genetic Disorders Affecting Tubulin Cytoskeleton [PDF]
Journal of Biomedical & Clinical Research, 2015 The tubulin cytoskeleton is vital for maintenance and dynamics of eukaryotic cells and molecular defects in its components can lead to serious conditions.
Maya Markova +5 more
doaj +3 more sources
A Balance between Nuclear and Cytoplasmic Volumes Controls Spindle Length. [PDF]
PLoS ONE, 2016 Proper assembly of the spindle apparatus is crucially important for faithful chromosome segregation during anaphase. Thanks to the effort over the last decades, we have very detailed information about many events leading to spindle assembly and ...
Lucia Novakova +5 more
doaj +1 more source
Evidence for spindle apparatus in somatic nuclei [PDF]
Fungal Genetics Reports, 1971 Evidence for spindle apparatus in somatic ...
W. B. Van Winkle, Van Winkle, W. B.
openaire +3 more sources
USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation. [PDF]
PLoS ONE, 2018 Correct segregation of the mitotic chromosomes into daughter cells is a highly regulated process critical to safeguard genome stability. During M phase the spindle assembly checkpoint (SAC) ensures that all kinetochores are correctly attached before its ...
Anna Stockum +2 more
doaj +1 more source
Cell Division, 2021 Background Ral family is a member of Ras-like GTPase superfamily, which includes RalA and RalB. RalA/B play important roles in many cell biological functions, including cytoskeleton dynamics, cell division, membrane transport, gene expression and signal ...
Ming-Hong Sun +7 more
doaj +1 more source
Mechanisms of spindle bipolarity establishment in acentrosomal human cells
Molecular & Cellular Oncology, 2020 Centrosomes are not absolutely essential for cell division; acentrosomal bipolar spindles can be established in oocytes and centrosome-eliminated somatic cells.
Kaho Hashimoto +2 more
doaj +1 more source
Human TPX2 is required for targeting Aurora-A kinase to the spindle [PDF]
, 2002 Aurora-A is a serine-threonine kinase implicated in the assembly and maintenance of the mitotic spindle. Here we show that human Aurora-A binds to TPX2, a prominent component of the spindle apparatus.
Roman Körner +18 more
core +1 more source