Plasmodium berghei Kinesin-5 Associates With the Spindle Apparatus During Cell Division and Is Important for Efficient Production of Infectious Sporozoites [PDF]
Frontiers in Cellular and Infection Microbiology, 2020 Kinesin-5 motors play essential roles in spindle apparatus assembly during cell division, by generating forces to establish and maintain the spindle bipolarity essential for proper chromosome segregation.
Mohammad Zeeshan +2 more
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Phase Transition of Spindle-Associated Protein Regulate Spindle Apparatus Assembly [PDF]
Cell, 2015 Spindle assembly required during mitosis depends on microtubule polymerization. We demonstrate that the evolutionarily conserved low-complexity protein, BuGZ, undergoes phase transition or coacervation to promote assembly of both spindles and their associated components.
Honggang Cui +2 more
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The Nuclear Mitotic Apparatus (NuMA) Protein: A Key Player for Nuclear Formation, Spindle Assembly, and Spindle Positioning [PDF]
Frontiers in Cell and Developmental Biology, 2021 The nuclear mitotic apparatus (NuMA) protein is well conserved in vertebrates, and dynamically changes its subcellular localization from the interphase nucleus to the mitotic/meiotic spindle poles and the mitotic cell cortex.
Tomomi Kiyomitsu
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A case of oculomotor nerve palsy associated with antimitotic spindle apparatus
Clinical Ophthalmology, 2011 Jong Jin Jung, Ungsoo Samuel KimDepartment of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, KoreaAbstract: In this case report, we describe a case of isolated oculomotor nerve palsy associated with antibodies ...
Jong Jin Jung
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Intermediate Filament Protein BFSP2 Controls Spindle Formation via HSC70‐Mediated Stabilization of CLTC During Oocyte meiosis [PDF]
Advanced ScienceAs a major component of the cytoskeleton, intermediate filaments are generally considered to play a supporting role in mitotic cells. They also take part in the regulation of cell motility, proliferation, differentiation, and apoptosis.
Yu Li, Zihao Zhang, Yu Zhang, Bo Xiong
doaj +2 more sources
Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution [PDF]
Advanced ScienceLipid droplets (LDs) are central to cellular energy homeostasis and lipid metabolism. While LD‐associated proteins are known to regulate LD dynamics and function, their roles in LD transport and their broader cellular significance remain poorly ...
Honggang Su +10 more
doaj +2 more sources
Spindle assembly defects leading to the formation of a monopolar mitotic apparatus [PDF]
Biology of the Cell, 2009 Mitotic spindle formation in animal cells involves microtubule nucleation from two centrosomes that are positioned at opposite sides of the nucleus. Microtubules are captured by the kinetochores and stabilized. In addition, microtubules can be nucleated independently of the centrosome and stabilized by a gradient of Ran—GTP, surrounding the mitotic ...
Brigitte Raynaud-Messina +2 more
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The nuclear-mitotic apparatus protein is important in the establishment and maintenance of the bipolar mitotic spindle apparatus. [PDF]
Molecular Biology of the Cell, 1992 The formation and maintenance of the bipolar mitotic spindle apparatus require a complex and balanced interplay of several mechanisms, including the stabilization and separation of polar microtubules and the action of various microtubule motors. Nonmicrotubule elements are also present throughout the spindle apparatus and have been proposed to provide
C H, Yang, M, Snyder
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Application of collagen triple helix repeat containing‐1 and mitotic spindle apparatus antibody in small cell lung cancer diagnosis [PDF]
Journal of Clinical Laboratory Analysis, 2022 Tingting Hu, Jianlin Yu, Liming Tan
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Nuclear Mitotic Apparatus (NuMA) Interacts with and Regulates Astrin at the Mitotic Spindle [PDF]
Journal of Biological Chemistry, 2016 The large nuclear mitotic apparatus (NuMA) protein is an essential player in mitotic spindle assembly and maintenance. We report here the identification of Astrin, a spindle- and kinetochore-associated protein, as a novel interactor of NuMA. We show that the C-terminal tail of NuMA can directly bind to the C terminus of Astrin and that this interaction
Xiaogang Chu +2 more
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