Results 11 to 20 of about 60,784 (278)

Genetic Disorders Affecting Tubulin Cytoskeleton [PDF]

open access: yesJournal of Biomedical & Clinical Research, 2015
The tubulin cytoskeleton is vital for maintenance and dynamics of eukaryotic cells and molecular defects in its components can lead to serious conditions.
Maya Markova   +5 more
doaj   +3 more sources

A Balance between Nuclear and Cytoplasmic Volumes Controls Spindle Length. [PDF]

open access: yesPLoS ONE, 2016
Proper assembly of the spindle apparatus is crucially important for faithful chromosome segregation during anaphase. Thanks to the effort over the last decades, we have very detailed information about many events leading to spindle assembly and ...
Lucia Novakova   +5 more
doaj   +1 more source

USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation. [PDF]

open access: yesPLoS ONE, 2018
Correct segregation of the mitotic chromosomes into daughter cells is a highly regulated process critical to safeguard genome stability. During M phase the spindle assembly checkpoint (SAC) ensures that all kinetochores are correctly attached before its ...
Anna Stockum   +2 more
doaj   +1 more source

Ral GTPase is essential for actin dynamics and Golgi apparatus distribution in mouse oocyte maturation

open access: yesCell Division, 2021
Background Ral family is a member of Ras-like GTPase superfamily, which includes RalA and RalB. RalA/B play important roles in many cell biological functions, including cytoskeleton dynamics, cell division, membrane transport, gene expression and signal ...
Ming-Hong Sun   +7 more
doaj   +1 more source

The association between muscle architecture and muscle spindle abundance

open access: yesScientific Reports, 2023
Across the human body, skeletal muscles have a broad range of biomechanical roles that employ complex proprioceptive control strategies to successfully execute a desired movement.
Roger W. P. Kissane   +3 more
doaj   +1 more source

A spindle-like apparatus guides bacterial chromosome segregation [PDF]

open access: yesNature Cell Biology, 2010
Until recently, a dedicated mitotic apparatus that segregates newly replicated chromosomes into daughter cells was believed to be unique to eukaryotic cells. Here we demonstrate that the bacterium Caulobacter crescentus segregates its chromosome using a partitioning (Par) apparatus that has surprising similarities to eukaryotic spindles.
Jerod L, Ptacin   +7 more
openaire   +2 more sources

Mechanisms of spindle bipolarity establishment in acentrosomal human cells

open access: yesMolecular & Cellular Oncology, 2020
Centrosomes are not absolutely essential for cell division; acentrosomal bipolar spindles can be established in oocytes and centrosome-eliminated somatic cells.
Kaho Hashimoto   +2 more
doaj   +1 more source

Spindle birefringence of isolated mitotic apparatus: further evidence for two birefringent spindle components [PDF]

open access: yesJournal of Cell Science, 1976
ABSTRACT We studied sea-urchin zygote mitotic apparatus (MA) isolated in hexylene glycol, transferred immediately to a glycerol-dimethylsulphoxide medium, and stored for 2 weeks at room temperature. Treatment with 0·5 M KC1 caused loss of 45% of the birefringence, but microtubules remained intact (as seen electron microscopically in ...
A, Forer, V I, Kalnins, A M, Zimmerman
openaire   +2 more sources

Uncovering the molecular machinery of the human spindle--an integration of wet and dry systems biology.

open access: yesPLoS ONE, 2012
The mitotic spindle is an essential molecular machine involved in cell division, whose composition has been studied extensively by detailed cellular biology, high-throughput proteomics, and RNA interference experiments.
Ana M Rojas   +20 more
doaj   +1 more source

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