Results 31 to 40 of about 6,495 (196)

Samp1, a RanGTP binding transmembrane protein in the inner nuclear membrane [PDF]

Nucleus, 2016
Samp1 is a transmembrane protein of the inner nuclear membrane (INM), which interacts with the nuclear lamina and the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex in interphase and during mitosis, it localizes to the mitotic spindle. Samp1 was recently found to coprecipitate a protein complex containing Ran, a GTPase with fundamental ...
Vijayaraghavan, Balaje, Jafferali, Mohammed Hakim, Figueroa, Ricardo A., Hallberg, Einar   +3 more
openaire   +2 more sources

Mitotic spindle scaling during Xenopus development by kif2a and importin α. [PDF]

, 2012
Early development of many animals is characterized by rapid cleavages that dramatically decrease cell size, but how the mitotic spindle adapts to changing cell dimensions is not understood.
HEALD, Rebecca, Wilbur, Jeremy
core   +2 more sources

ISWI is a RanGTP-dependent MAP required for chromosome segregation [PDF]

Journal of Cell Biology, 2009
Production of RanGTP around chromosomes induces spindle assembly by activating nuclear localization signal (NLS)–containing factors. Here, we show that the NLS protein ISWI, a known chromatin-remodeling ATPase, is a RanGTP-dependent microtubule (MT)-associated protein. Recombinant ISWI induces MT nucleation, stabilization, and bundling in vitro.
Yokoyama, Hideki, Rybina, Sofia, Santarella-Mellwig, Rachel, Mattaj, Iain W., Karsenti, Eric   +4 more
openaire   +2 more sources

Non-centrosomal TPX2-dependent regulation of the Aurora A kinase: functional implications for healthy and pathological cell division

Frontiers in Oncology, 2016
Aurora A has been extensively characterized as a centrosomal kinase with essential functions during cell division including centrosome maturation and separation and spindle assembly. However, Aurora A localization is not restricted to the centrosomes and
Isabelle eVernos, Isabelle eVernos, Isabelle eVernos, Isabelle eVernos, Georgina eGarrido, Georgina eGarrido, Georgina eGarrido   +6 more
doaj   +1 more source

In vivo FRET imaging revealed a regulatory role of RanGTP in kinetochore-microtubule attachments via Aurora B kinase.

PLoS ONE, 2012
Under the fluctuating circumstances provided by the innate dynamics of microtubules and opposing tensions resulted from microtubule-associated motors, it is vital to ensure stable kinetochore-microtubule attachments for accurate segregation.
Yoke-Peng Lee, Chi-Hang Wong, Kheng-Sze Chan, Soak-Kuan Lai, Cheng-Gee Koh, Hoi-Yeung Li   +5 more
doaj   +1 more source

RNF31 induces paclitaxel resistance by sustaining ALYREF cytoplasmic-nuclear shuttling in human triple-negative breast cancer. [PDF]

Clin Transl Med
An overview of the paclitaxel resistance mechanism induced by RNF31‐mediated ALYREF subcellular distribution. RNF31 promoted the linear ubiquitination of ALYREF, subsequently enhancing ALYREF nuclear transport via IPO13 upon PTX treatment. In addition, RNF31‐mediated ubiquitination of ALYREF facilitated ALYREF binding and export of PTX resistance ...
Huang S, Shi D, Dai S, Jiang X, Wang R, Yang M, Chen B, Chen X, Kong L, He L, Deng P, Chen X, Lin C, Li Y, Li J, Song L, Shi Y, Wei W.   +17 more
europepmc   +2 more sources

Importin-beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function [PDF]

, 2017
Protein conjugation with small ubiquitin-related modifier (SUMO) is a post-translational modification that modulates protein interactions and localisation.
Damizia, Michela, DE SANTIS, RICCARDO, DE TURRIS, VALERIA, GILISTRO, EUGENIA, Lavia, Patrizia, MORONI, SARA, ROSA, ALESSANDRO, VERRICO, ANNALISA   +7 more
core   +1 more source

Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential [PDF]

, 2016
The Karyopherin superfamily is a major class of soluble transport receptors consisting of both import and export proteins. The trafficking of proteins involved in transcription, cell signalling and cell cycle regulation among other functions across the ...
Aggarwal, Albee, Alnabulsi, Alshareeda, Altan, Angus, Behrens, Bernis, Blower, Brinkmann, Brinkmann, Cansizoglu, Chang, Christiansen, Dahl, Das, Dasso, Depping, Dikovskaya, Forbes, Gluz, Gontan, Gorlich, Gousias, Gousias, Gousias, Grupp, Gruss, Hashimoto, Hintersteiner, Hu, Huang, Huang, Huang, Hutchins, Hügel, Ishizawa, Jensen, Jiang, Kahle, Kau, Kazim, Kim, Kimura, King, Knauer, Kojima, Kosugi, Kudo, Kurisaki, Kutay, Kuusisto, Kuusisto, Lapalombella, Latvia, Lau, Laurila, Li, Liang, Liao, Lin, Lin, Lorenzato, Ma, Marfori, Martens-de Kemp, Melo, Mortezavi, Mosammaparast, Muller, Nevins, Noske, Parikh, Poon, Pumroy, Quan, Quensel, Rensen, Sakai, Scherf, Shen, Shi, Shiraki, Sillje, Smith, Smith, Soderholm, Song, Stawerski, Stella Tsai, Stewart, Tai, Torgerson, Turner, Turner, Wagstaff, Wang, Wang, Wang, Watt, Watt, Watt, Wellmann, Wiese, Winkler, Winnepenninckx, Wu, Yan, Yang, Yao, Yoshitake, Yu, Zender, Zheng, Zhou, Zhu, Zhu, Zienkiewicz   +117 more
core   +1 more source

Canoe binds RanGTP to promote PinsTPR/Mud-mediated spindle orientation [PDF]

Journal of Cell Biology, 2011
Regulated spindle orientation maintains epithelial tissue integrity and stem cell asymmetric cell division. In Drosophila melanogaster neural stem cells (neuroblasts), the scaffolding protein Canoe (Afadin/Af-6 in mammals) regulates spindle orientation, but its protein interaction partners and mechanism of action are unknown.
Wee, Brett, Johnston, Christopher A., Prehoda, Kenneth E., Doe, Chris Q.   +3 more
openaire   +2 more sources

Karyopherins regulate nuclear pore complex barrier and transport function [PDF]

, 2017
Nucleocytoplasmic transport is sustained by karyopherins (Kaps) and a Ran guanosine triphosphate (RanGTP) gradient that imports nuclear localization signal (NLS)–specific cargoes (NLS-cargoes) into the nucleus.
Adam, Allen, Bayliss, Bednenko, Ben-Efraim, Binlu Huang, Bischoff, Catimel, Chaillan-Huntington, Chantal Rencurel, Chook, Christie, Cingolani, Cingolani, Conti, Delphin, Eibauer, Eisele, Falces, Floer, Forwood, Forwood, Frey, Fukuhara, Grünwald, Görlich, Görlich, Görlich, Görlich, Hahn, Halder, Hough, Isgro, Kapinos, Kau, Kimura, Kopito, Kubitscheck, Kutay, Kutay, Larisa E. Kapinos, Lee, Lee, Lim, Lim, Lolodi, Lonhienne, Lowe, Lyman, Makise, Milles, Moroianu, Moroianu, Nigg, Ogawa, Paradise, Popken, Pumroy, Pyhtila, Rexach, Ribbeck, Riddick, Roderick Y.H. Lim, Rout, Sakiyama, Schoch, Stewart, Strawn, Sun, Tauchert, Timney, Tokunaga, Tu, von Appen, Vovk, Wagner, Weis, Yamada, Yang, Yang, Yoshimura, Zachariae   +81 more
core   +1 more source