Results 41 to 50 of about 3,517 (188)
Frontiers in Oncology, 2016 Aurora A has been extensively characterized as a centrosomal kinase with essential functions during cell division including centrosome maturation and separation and spindle assembly. However, Aurora A localization is not restricted to the centrosomes and
Isabelle eVernos +6 more
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NuSAP, a Mitotic RanGTP Target That Stabilizes and Cross-links Microtubules [PDF]
Molecular Biology of the Cell, 2006 Nucleolar and spindle-associated protein (NuSAP) was recently identified as a microtubule- and chromatin-binding protein in vertebrates that is nuclear during interphase. Small interfering RNA-mediated depletion of NuSAP resulted in aberrant spindle formation, missegregation of chromosomes, and ultimately blocked cell proliferation.
Ribbeck, K. +13 more
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PLoS ONE, 2012 Under the fluctuating circumstances provided by the innate dynamics of microtubules and opposing tensions resulted from microtubule-associated motors, it is vital to ensure stable kinetochore-microtubule attachments for accurate segregation.
Yoke-Peng Lee +5 more
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Scientific Reports, 2022 Nucleocytoplasmic transport (NCT) is affected in several neurodegenerative diseases including C9orf72-ALS. It has recently been found that arginine-containing dipeptide repeat proteins (R-DPRs), translated from C9orf72 repeat expansions, directly bind to
Hamidreza Jafarinia +2 more
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New mitotic regulators released from chromatin
Frontiers in Oncology, 2013 Faithful action of the mitotic spindle segregates duplicated chromosomes into daughter cells. Perturbations of this process result in chromosome mis-segregation, leading to chromosomal instability and cancer development.
Hideki eYokoyama, Oliver eGruss
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A protein inventory of human ribosome biogenesis reveals an essential function of exportin 5 in 60S subunit export. [PDF]
PLoS Biology, 2010 The assembly of ribosomal subunits in eukaryotes is a complex, multistep process so far mostly studied in yeast. In S. cerevisiae, more than 200 factors including ribosomal proteins and trans-acting factors are required for the ordered assembly of 40S ...
Thomas Wild +9 more
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RanGTP and the actin cytoskeleton keep paternal and maternal chromosomes apart during fertilization [PDF]
Journal of Cell Biology, 2021 Zygotes require two accurate sets of parental chromosomes, one each from the mother and the father, to undergo normal embryogenesis. However, upon egg–sperm fusion in vertebrates, the zygote has three sets of chromosomes, one from the sperm and two from the egg.
Masashi Mori +10 more
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Mechanism of RanGTP dependent microtubule assembly during mitosis [PDF]
, 2014 During mitosis, spindle assembly involves different sources of microtubules including centrosomes and chromosomes. While the role of centrosomes has been extensively studied, we still do not fully understand how chromosomes trigger microtubule assembly ...
Scrofani, Jacopo
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The first identified nucleocytoplasmic shuttling herpesviral capsid protein: herpes simplex virus type 1 VP19C. [PDF]
PLoS ONE, 2012 VP19C is a structural protein of herpes simplex virus type 1 viral particle, which is essential for assembly of the capsid. In this study, a nuclear export signal (NES) of VP19C is for the first time identified and mapped to amino acid residues 342 to ...
Lei Zhao, Chunfu Zheng
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Understanding RanGTP dependent microtubule assembly : Idenification of DnaJB6 as a RanGTP regulated factor involved in microtubule organization during mitosis [PDF]
, 2017 Three microtubule (MT) assembly pathways participate in the assembly of the bipolar spindle: the centrosomal pathway, the augmin dependent amplification pathway and the RanGTP/chromosome dependent pathway. To form the spindle, all these MTs are organized
Rosas Salvans, Miquel
core +1 more source