Results 41 to 50 of about 6,495 (196)
The strategy for coupling the RanGTP gradient to nuclear protein export [PDF]
Proceedings of the National Academy of Sciences, 2003 The Ran GTPase plays critical roles in both providing energy for and determining the directionality of nucleocytoplasmic transport. The mechanism that couples the RanGTP gradient to nuclear protein export will determine the rate of and limits to accumulation of export cargoes in the cytoplasm, but is presently unknown.
Becskei, Attila, Mattaj, Iain W.
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Scientific Reports, 2022 Nucleocytoplasmic transport (NCT) is affected in several neurodegenerative diseases including C9orf72-ALS. It has recently been found that arginine-containing dipeptide repeat proteins (R-DPRs), translated from C9orf72 repeat expansions, directly bind to
Hamidreza Jafarinia +2 more
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New mitotic regulators released from chromatin
Frontiers in Oncology, 2013 Faithful action of the mitotic spindle segregates duplicated chromosomes into daughter cells. Perturbations of this process result in chromosome mis-segregation, leading to chromosomal instability and cancer development.
Hideki eYokoyama, Oliver eGruss
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An agent-based model for mRNA export through the nuclear pore complex. [PDF]
, 2014 mRNA export from the nucleus is an essential step in the expression of every protein- coding gene in eukaryotes, but many aspects of this process remain poorly understood.
Azimi, Mohammad +3 more
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A Functional Connection between RanGTP, NF-κB and Septic Shock
Journal of Biomedical Science, 2003 RanGTPase is importantly involved in diverse biological functions, such as nuclear transport, spindle formation during mitosis, DNA replication and cell division. This review summarizes yet another new role of Ran - control of the activity of NF-kappaB in host immune responses.
Peter M C, Wong, Siu-Wah, Chung
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NuSAP, a Mitotic RanGTP Target That Stabilizes and Cross-links Microtubules [PDF]
Molecular Biology of the Cell, 2006 Nucleolar and spindle-associated protein (NuSAP) was recently identified as a microtubule- and chromatin-binding protein in vertebrates that is nuclear during interphase. Small interfering RNA-mediated depletion of NuSAP resulted in aberrant spindle formation, missegregation of chromosomes, and ultimately blocked cell proliferation.
Ribbeck, K. +13 more
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Separable roles for RanGTP in nuclear and ciliary trafficking of a kinesin-2 subunit [PDF]
Journal of Biological Chemistry, 2021 Kinesin is part of the microtubule-binding motor protein superfamily, which serves important roles in cell division and intraorganellar transport. The heterotrimeric kinesin-2, consisting of the heterodimeric motor subunits, kinesin family member 3A/3B (KIF3A/3B), and kinesin-associated protein 3 (KAP3), is highly conserved across species from the ...
Shengping Huang +2 more
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A protein inventory of human ribosome biogenesis reveals an essential function of exportin 5 in 60S subunit export. [PDF]
PLoS Biology, 2010 The assembly of ribosomal subunits in eukaryotes is a complex, multistep process so far mostly studied in yeast. In S. cerevisiae, more than 200 factors including ribosomal proteins and trans-acting factors are required for the ordered assembly of 40S ...
Thomas Wild +9 more
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GAP activity, but not subcellular targeting, is required for Arabidopsis RanGAP cellular and developmental functions [PDF]
, 2015 The Ran GTPase activating protein (RanGAP) is important to Ran signaling involved in nucleocytoplasmic transport, spindle organization, and postmitotic nuclear assembly.
Boruc, Joanna +6 more
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The first identified nucleocytoplasmic shuttling herpesviral capsid protein: herpes simplex virus type 1 VP19C. [PDF]
PLoS ONE, 2012 VP19C is a structural protein of herpes simplex virus type 1 viral particle, which is essential for assembly of the capsid. In this study, a nuclear export signal (NES) of VP19C is for the first time identified and mapped to amino acid residues 342 to ...
Lei Zhao, Chunfu Zheng
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