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A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection
Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi +9 more
wiley +1 more source
The interaction of RNA helicase DDX3 with HIV-1 Rev-CRM1-RanGTP complex during the HIV replication cycle. [PDF]
, 2015 Molecular traffic between the nucleus and the cytoplasm is regulated by the nuclear pore complex (NPC), which acts as a highly selective channel perforating the nuclear envelope in eukaryotic cells.
Seyed Hanif Mahboobi (550483) +8 more
core +1 more source
, 2022 CRM1 is a nuclear export receptor that has been intensively targeted over the last decade for the development of antitumor and antiviral drugs. Structural analysis of several inhibitor compounds bound to CRM1 revealed that their mechanism of action ...
Ficner, Ralf +6 more
core +1 more source
Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP [PDF]
, 2010 The biogenesis, maintenance and function of primary cilia are controlled through intraflagellar transport (IFT) driven by two kinesin-2 family members, the heterotrimeric KIF3A/KIF3B/KAP complex and the homodimeric KIF17 motor. How these motors and their
Martens, Jeffrey R +19 more
core +1 more source
, 2021 CRM1 is a nuclear export receptor that has been intensively targeted over the last decade for the development of antitumor and antiviral drugs. Structural analysis of several inhibitor compounds bound to CRM1 revealed that their mechanism of action ...
Ficner, Ralf +6 more
core +1 more source
, 2002 Vertebrate tRNA export receptor exportin-t (Xpo-t) binds to RanGTP and mature tRNAs cooperatively to form a nuclear export complex. Xpo-t shuttles bidirectionally through nuclear pore complexes (NPCs) but is mainly nuclear at steady state.
Scott Kuersten +4 more
core +1 more source
The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus. [PDF]
, 1997 The GTPase Ran is essential for nuclear import of proteins with a classical nuclear localization signal (NLS). Ran's nucleotide‐bound state is determined by the chromatin‐bound exchange factor RCC1 generating RanGTP in the nucleus and the cytoplasmic ...
Izaurralde, E. +9 more
core +1 more source
Mechanism of RanGTP dependent microtubule assembly during mitosis
During mitosis, spindle assembly involves different sources of microtubules including centrosomes and chromosomes. While the role of centrosomes has been extensively studied, we still do not fully understand how chromosomes trigger microtubule assembly ...
Scrofani, Jacopo
core
, 2005 SummaryThe roles of the kinase Aurora A (AurA) in centrosome function and spindle assembly [1–3] have been established in Drosophila [4, 5], C. elegans [6], and Xenopus egg extracts [7–9].
Tsai, Ming-Ying, Zheng, Yixian
core +1 more source
(A) RanGTP was detected using an antibody directed against the active form of Ran after 72 h of siRNA treatment. (B) Quantitation of RanGTP signal intensity in control and CFDP1 siRNA-treated cells.
Qian Xu (119888) +3 more
core +1 more source