Results 61 to 70 of about 3,517 (188)
A Functional Connection between RanGTP, NF-κB and Septic Shock
Journal of Biomedical Science, 2003 RanGTPase is importantly involved in diverse biological functions, such as nuclear transport, spindle formation during mitosis, DNA replication and cell division. This review summarizes yet another new role of Ran - control of the activity of NF-kappaB in host immune responses.
Peter M C, Wong, Siu-Wah, Chung
openaire +2 more sources
Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source
Nature Communications, 2016 Xpo4 imports Sox2 and other proteins into the cell nucleus, while exporting eIF5A or Smad3; how it recognizes these proteins has been unclear. Here, the authors solved the crystal structure of the RanGTP, Xpo4 and eIF5A complex and investigate how Xpo4 ...
Metin Aksu +2 more
doaj +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, Volume 7, Issue 3, Page 109-124, September 2026.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Noncoding RNAs and the Architecture of Gene Regulation: Focus on Long and Small Regulatory RNAs
WIREs RNA, Volume 17, Issue 4, July/August 2026.NcRNAs play fundamental roles in many facets of cellular homeostasis, systemic physiology and disease outcomes. Historical and current advancements have led to a deeper understanding of ncRNAs' roles, utilizing their diverse and tissue‐specific functions to drive the development of innovative therapeutic tools.
Samuel Z. Desind +2 more
wiley +1 more source
A centriole- and RanGTP-independent spindle assembly pathway in meiosis I of vertebrate oocytes
, 2007 International audienceSpindle formation is essential for stable inheritance of genetic material. Experiments in various systems indicate that Ran GTPase is crucial for meiotic and mitotic spindle assembly.
Rassinier, Pascale +22 more
core +1 more source
A mechanism of coupling RCC1 mobility to RanGTP production on the chromatin in vivo [PDF]
The Journal of Cell Biology, 2003 The RanGTP gradient across the interphase nuclear envelope and on the condensed mitotic chromosomes is essential for many cellular processes, including nucleocytoplasmic transport and spindle assembly. Although the chromosome-associated enzyme RCC1 is responsible for RanGTP production, the mechanism of generating and maintaining the RanGTP gradient in ...
Li, Hoi Yeung +2 more
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, 2012 The multi-faceted RanGTPase has been implicated to be critically involved in nucleocytoplasmic transportation and cell cycle progression. However, the role of mitotic RanGTP in kinetochore-microtubule attachments at metaphase has yet to be described ...
Lee, Yoke Peng
core +1 more source
FEBS Open Bio, Volume 16, Issue 5, Page 921-931, May 2026.NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi +6 more
wiley +1 more source
Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration.
PLoS Pathogens, 2011 The HIV/AIDS pandemic is a major global health threat and understanding the detailed molecular mechanisms of HIV replication is critical for the development of novel therapeutics.
Lihong Zhou +5 more
doaj +1 more source