Results 71 to 80 of about 6,495 (196)
The interaction of CRM1 and the nuclear pore protein Tpr.
PLoS ONE, 2014 While much has been devoted to the study of transport mechanisms through the nuclear pore complex (NPC), the specifics of interactions and binding between export transport receptors and the NPC periphery have remained elusive.
Charles L Zhao +3 more
doaj +1 more source
Chromatids segregate without centrosomes during Caenorhabditis elegans mitosis in a Ran- and CLASP-dependent manner [PDF]
, 2015 This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License ...
Askjaer, Peter +3 more
core +3 more sources
Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source
Nature Communications, 2016 Xpo4 imports Sox2 and other proteins into the cell nucleus, while exporting eIF5A or Smad3; how it recognizes these proteins has been unclear. Here, the authors solved the crystal structure of the RanGTP, Xpo4 and eIF5A complex and investigate how Xpo4 ...
Metin Aksu +2 more
doaj +1 more source
RanGAP1 is a continuous marker of the Arabidopsis cell division plane [PDF]
, 2008 In higher plants, the plane of cell division is faithfully predicted by the preprophase band (PPB). The PPB, a cortical ring of microtubules and F-actin, disassembles upon nuclear-envelope breakdown.
X. M. Xu +21 more
core +1 more source
RanGTP-Regulated Interactions of CRM1 with Nucleoporins and a Shuttling DEAD-Box Helicase [PDF]
Molecular and Cellular Biology, 1999 CRM1 is an export receptor mediating rapid nuclear exit of proteins and RNAs to the cytoplasm. CRM1 export cargoes include proteins with a leucine-rich nuclear export signal (NES) that bind directly to CRM1 in a trimeric complex with RanGTP. Using a quantitative CRM1-NES cargo binding assay, significant differences in affinity for CRM1 among natural ...
Askjaer, Peter +10 more
openaire +2 more sources
ChemistryEurope, Volume 4, Issue 4, April 2026.Local activity of antagonistic enzymes results in the formation of ATP‐concentration gradients that persist in time as long as chemical fuel is present in the hydrogel. At the macroscopic nonequilibrium steady state the concentration gradients confine the ATP‐templated self‐assembly of surfactants to well‐defined areas of the gel.
Yingjuan Cao +4 more
wiley +1 more source
RanGTP-mediated nuclear export of karyopherin α involves its interaction with the nucleoporin Nup153 [PDF]
Proceedings of the National Academy of Sciences, 1997 Using binding assays, we discovered an interaction between karyopherin α2 and the nucleoporin Nup153 and mapped their interacting domains. We also isolated a 15-kDa tryptic fragment of karyopherin β1, termed β1*, that contains a determinant for binding to the peptide repeat containing nucleoporin Nup98. In an in vitro
J, Moroianu, G, Blobel, A, Radu
openaire +2 more sources
Identification of a Small Molecule Inhibitor of Importin β Mediated Nuclear Import by Confocal On-Bead Screening of Tagged One-Bead One-Compound Libraries [PDF]
, 2010 In eukaryotic cells, proteins and RNAs are transported between the nucleus and the cytoplasm by nuclear import and export receptors. Over the past decade, small molecules that inhibit the nuclear export receptor CRM1 have been identified, most notably ...
Ambrus, Geza +10 more
core +1 more source
Nuclear RanGTP is not required for targeting small nucleolar RNAs to the nucleolus [PDF]
Journal of Cell Science, 2003 The small GTPase Ran is the central regulator of macromolecular transport between the cytoplasm and the nucleus. Recent work has suggested that RanGTP also plays an important role in regulating some intra-nuclear processes. In this study, we have investigated whether RanGTP is required for the intra-nuclear transport of RNAs.
Aarthi, Narayanan +6 more
openaire +2 more sources