Results 71 to 80 of about 3,517 (188)
RanGTP induces an effector gradient of XCTK2 and importin α/β for spindle microtubule cross-linking
, 2020 High RanGTP around chromatin is important for governing spindle assembly during meiosis and mitosis by releasing the inhibitory effects of importin alpha/beta Here we examine how the Ran gradient regulates Kinesin-14 function to control spindle ...
Stephanie Zhang +11 more
core +1 more source
The effect of camptothecin on nuclear RanGTP levels in HeLa cells
The FASEB Journal, 2013 Nuclear transport is essential for the survival of all cells. The flow of molecules passing through the nuclear envelope via nuclear pore complexes is mediated by the karyopherin protein family, consisting of importins and exportins to which cargo can bind. The directionality of nuclear transport is regulated by a small GTPase, Ran.
Amy Marie Steinheiser, Karen K. Resendes
openaire +1 more source
Scientific Reports, 2019 TMX2 is a thioredoxin family protein, but its functions have not been clarified. To elucidate the function of TMX2, we explored TMX2-interacting proteins by LC-MS. As a result, importin-β, Ran GTPase (Ran), RanGAP, and RanBP2 were identified.
Ami Oguro, Susumu Imaoka
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Anaplasma phagocytophilum, a tick-borne obligately intracellular bacterium of neutrophils, causes human granulocytic anaplasmosis. Ankyrin A (AnkA), an effector protein with multiple ankyrin repeats (AR) is injected via type IV-secretion into the host ...
Yuri Kim +6 more
doaj +1 more source
ChemistryEurope, Volume 4, Issue 4, April 2026.Local activity of antagonistic enzymes results in the formation of ATP‐concentration gradients that persist in time as long as chemical fuel is present in the hydrogel. At the macroscopic nonequilibrium steady state the concentration gradients confine the ATP‐templated self‐assembly of surfactants to well‐defined areas of the gel.
Yingjuan Cao +4 more
wiley +1 more source
, 2012 In the presence of high mitotic RanGTP, Crm1 is localized to the kinetochores. Mst1 is then recruited as part of the RanGTP-Crm1-Mst1 ternary complex. The presence of Mst1 limits the autophosphorylation of Aurora B kinase and thus stabilizes kinetochore ...
Hoi-Yeung Li (130681) +5 more
core +1 more source
Identification of different roles for RanGDP and RanGTP in nuclear protein import. [PDF]
The EMBO Journal, 1996 The importin-alpha/beta heterodimer and the GTPase Ran play key roles in nuclear protein import. Importin binds the nuclear localization signal (NLS). Translocation of the resulting import ligand complex through the nuclear pore complex (NPC) requires Ran and is terminated at the nucleoplasmic side by its disassembly.
Görlich, D. +4 more
openaire +3 more sources
Scientific ReportsIn eukaryotes, the ubiquitin–proteasome system is an essential pathway for protein degradation and cellular homeostasis. 26S proteasomes concentrate in the nucleus of budding yeast Saccharomyces cerevisiae due to the essential import adaptor protein Sts1
Carolyn Allain Breckel +3 more
doaj +1 more source
The Ran pathway in Drosophila melanogaster mitosis
Frontiers in Cell and Developmental Biology, 2015 Over the last two decades, the small GTPase Ran has emerged as a central regulator of both mitosis and meiosis, particularly in the generation, maintenance and regulation of the microtubule (MT)-based bipolar spindle.
James G Wakefield +3 more
doaj +1 more source
Structural Insights Into the Nuclear Import of Gallid Alphaherpesvirus 1 Large Tegument Protein
MicrobiologyOpen, Volume 15, Issue 1, February 2026.The study identifies and characterizes a bipartite nuclear localization signal within the GaAHV‐1 UL36 large tegument protein, revealing its structural interaction with importin α/β1 and confirming a conserved mechanism of nuclear import through biochemical, crystallographic, and mutational analyses.
Babu Kanti Nath +7 more
wiley +1 more source