Results 91 to 100 of about 3,517 (188)

Structural Insights Into the Nuclear Import of Marek’s Disease Virus Large Tegument Protein

Advances in Virology, Volume 2026, Issue 1, 2026.
Marek’s disease (MD) is a highly contagious neoplastic disorder of poultry caused by MD virus (MDV; gallid alphaherpesvirus 2 [GaAHV2]). Infection results in profound immunosuppression, neurological dysfunction, and the development of malignant T‐cell lymphomas.
Babu Kanti Nath, Renate H. M. Schwab, Camilla M. Donnelly, Daryl Ariawan, Ole Tietz, Jade K. Forwood, Subir Sarker, Pavitra Roychoudhury   +7 more
wiley   +1 more source

The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA

eLife, 2014
The HIV Rev protein routes viral RNAs containing the Rev Response Element (RRE) through the Crm1 nuclear export pathway to the cytoplasm where viral proteins are expressed and genomic RNA is delivered to assembling virions.
David S Booth, Yifan Cheng, Alan D Frankel   +2 more
doaj   +1 more source

Identification and Validation of Mitophagy‐Related Biomarkers in Colorectal Cancer: An Integrated Analysis of Single‐Cell Transcriptome and Mendelian Randomization

Genetics Research , Volume 2026, Issue 1, 2026.
Mitophagy is essential for cancer formation and invasion, but its role in colorectal cancer (CRC) remains unclear. We obtained sequencing data and mitophagy‐related genes (MP‐RGs) from public databases. Differential expression analysis and weighted gene coexpression network analysis (WGCNA) identified mitophagy‐related differentially expressed genes ...
Jingyi Zhao, Meng Kong, Sining Wang, Zhixin Cao, Xiangguo Tian, Hongda Liu   +5 more
wiley   +1 more source

Aurora A Kinase-Coated Beads Function as Microtubule-Organizing Centers and Enhance RanGTP-Induced Spindle Assembly [PDF]

, 2005
SummaryThe roles of the kinase Aurora A (AurA) in centrosome function and spindle assembly [1–3] have been established in Drosophila [4, 5], C. elegans [6], and Xenopus egg extracts [7–9].
Tsai, Ming-Ying, Zheng, Yixian
core   +1 more source

Prematurely Aged Human Microglia Exhibit Impaired Stress Response and Defective Nucleocytoplasmic Shuttling of ALS Associated FUS

Aging Cell, Volume 24, Issue 11, November 2025.
We developed a human microglia aging model by doxycycline‐induced GFP‐progerin expression, which offers a valuable tool to study human microglial aging and its contribution to neurodegeneration. Induced HMC3‐Progerin cells exhibited increased age markers as well as transcriptomic alterations, including an age‐associated transcriptomic shift and ...
Christiane Hartmann, Christina Haß, Muriel Knobloch, Israel Barrantes, Laura Fumagalli, Jessie Premereur, Franz Markert, Maite Peters, Georgia Koromila, Alexander Hartmann, Kathrin Jäger, Jette Abel, Renzo Mancuso, Alexander Storch, Michael Walter, Georg Fuellen, Andreas Hermann   +16 more
wiley   +1 more source

The Small GTPase Ran Increases Sensitivity of Ovarian Cancer Cells to Oncolytic Vesicular Stomatitis Virus

Pharmaceuticals
Background/Objectives: Ovarian cancer is the deadliest gynecologic cancer, and with the majority of patients dying within the first five years of diagnosis, new therapeutic options are required.
Karen Geoffroy, Mélissa Viens, Emma Mary Kalin, Zied Boudhraa, Dominic Guy Roy, Jian Hui Wu, Diane Provencher, Anne-Marie Mes-Masson, Marie-Claude Bourgeois-Daigneault   +8 more
doaj   +1 more source

Release of condensin from mitotic chromosomes requires the Ran-GTP gradient in the reorganized nucleus

Biology Open, 2017
After mitosis, nuclear reorganization occurs together with decondensation of mitotic chromosomes and reformation of the nuclear envelope, thereby restoring the Ran-GTP gradient between the nucleus and cytoplasm.
Keita Aoki, Hironori Niki
doaj   +1 more source

NEDD1-S411 phosphorylation plays a critical function in the coordination of microtubule nucleation during mitosis

Biology Open, 2022
Krystal Timón Pérez, Jacopo Scrofani, Isabelle Vernos   +2 more
doaj   +1 more source

Crystal structure of human CRM1, covalently modified by 2‐mercaptoethanol on Cys528, in complex with RanGTP

, 2022
CRM1 is a nuclear export receptor that has been intensively targeted over the last decade for the development of antitumor and antiviral drugs. Structural analysis of several inhibitor compounds bound to CRM1 revealed that their mechanism of action ...
Ficner, Ralf, Schmitt, Kerstin; 2Department of Molecular Microbiology and Genetics, Georg-August-Universität Göttingen, Grisebachstrasse 8, 37077Göttingen, Germany, Valerius, Oliver; 2Department of Molecular Microbiology and Genetics, Georg-August-Universität Göttingen, Grisebachstrasse 8, 37077Göttingen, Germany, Shaikhqasem, Alaa, Schmitt, Kerstin, Shaikhqasem, Alaa; 1Department for Molecular Structural Biology, Georg-August-Universität Göttingen, Justus-von-Liebig Weg 11, 37077Göttingen, Germany, Valerius, Oliver   +6 more
core   +1 more source

Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export

Cell Reports, 2015
CRM1 is the major nuclear export receptor. During translocation through the nuclear pore, transport complexes transiently interact with phenylalanine-glycine (FG) repeats of multiple nucleoporins. On the cytoplasmic side of the nuclear pore, CRM1 tightly
Sarah A. Port, Thomas Monecke, Achim Dickmanns, Christiane Spillner, Romina Hofele, Henning Urlaub, Ralf Ficner, Ralph H. Kehlenbach   +7 more
doaj   +1 more source