Results 91 to 100 of about 3,329 (143)

Inhibition of nuclear import suppresses androgen receptor action and overcomes resistance in prostate cancer. [PDF]

BMC Cancer
Wang X, Xu X, Fang S, Shi X, Yang Y.
europepmc   +1 more source

Small molecule JRMS modulating importin-β1 chaperone activity as a therapeutic strategy reducing TDP-43 pathology. [PDF]

Neurotherapeutics
Shenouda M, Shenouda S, Kartono B, Eid S, Cheng C, Robertson J.   +5 more
europepmc   +1 more source

A multivalent adaptor mechanism drives the nuclear import of proteasomes. [PDF]

Nat Commun
Brunner HL, Kalis RW, Grundmann L, Hodáková Z, Koskova Z, Grishkovskaya I, de Almeida M, Hinterndorfer M, Knaudt H, Höfflin S, Andersch F, Kotisch H, Dickmanns A, Cuylen-Haering S, Zuber J, Haselbach D.   +15 more
europepmc   +1 more source

Hallmarks of nuclear metabolism: implications for genome integrity, nuclear signaling, and therapeutic targeting. [PDF]

NPJ Metab Health Dis
Schmidt A, Pfeiffer M, Sdelci S.
europepmc   +1 more source

Mobilization of nuclear antiviral factors by exportin XPO1 via the actin network inhibits RNA virus replication. [PDF]

PLoS Pathog
Sun B, Wu CY, Gonzalez PA, Nagy PD.
europepmc   +1 more source

Exploration of the proxiOME of large subunit ribosomal proteins reveals Acl1 and Bcl1 as cooperating dedicated chaperones of Rpl1. [PDF]

Nucleic Acids Res
Favre S, Pillet B, Burchert F, Siva Sankar D, Méndez-Godoy A, Kiontke S, Dengjel J, Bange G, Kressler D.   +8 more
europepmc   +1 more source

Tandem Duplications in UBTF Create XPO1-Dependent Nuclear Export Signals that Reveal a Leukemic Therapeutic Dependency. [PDF]

Blood Cancer Discov
Barajas JM, Phillips AH, Wang J, Thomas ME, Contreras L, Umeda M, Hiltenbrand R, Caldwell E, Walsh MP, Song G, Ezzell L, Churion K, Westover T, Xiong E, Rolle C, Moore J, Lott J, Radko-Juettner S, Kumar A, Qi W, Xu B, Papachristou EK, D'Santos CS, Ma J, Freeman BB, Janke LJ, Kriwacki RW, Klco JM.   +27 more
europepmc   +1 more source

Charge of karyopherins and nuclear FG-Nups are key ingredients of nucleocytoplasmic transport. [PDF]

Biophys J
Mishra A, Van der Giessen E, Onck PR.
europepmc   +1 more source

Identification of locally activated spindle-associated proteins in oocytes uncovers a phosphatase-driven mechanism. [PDF]

J Cell Sci
Wan X, Pavlova G, Cullen CF, Dasuzhau I, Ciszek A, Ohkura H.   +5 more
europepmc   +2 more sources

Breaking barriers: Respiratory viral strategies targeting the host's nuclear pore complex and nuclear transport pathways. [PDF]

Mol Biol Cell
Udi Y, Aitchison JD, Rout MP, Obado S.
europepmc   +1 more source