Results 111 to 120 of about 6,495 (196)

The Pseudorabies Virus DNA Polymerase Accessory Subunit UL42 Directs Nuclear Transport of the Holoenzyme [PDF]

, 2016
Pseudorabies virus (PRV) DNA replication occurs in the nuclei of infected cells and requires the viral DNA polymerase. The PRV DNA polymerase comprises a catalytic subunit, UL30, and an accessory subunit, UL42, that confers processivity to the enzyme ...
Chang-Ming Liu, Hong-Li Wu, Li Feng, Li-Ping Huang, Wen-Juan Du, Yan-Wu Wei, Yi-Ping Wang   +6 more
core   +2 more sources

A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection

Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.
Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi, Asiyeh Jebelli, Parisa Shiri Aghbash, Behzad Baradaran, Mohammad Amini, Fatemeh Oroojalian, Nasser Pouladi, Hossein Bannazadeh Baghi, Miguel de la Guardia, Amir Ali Mokhtarzadeh   +9 more
wiley   +1 more source

A sejtmagi fehérje-import Importin-alfa2 faktorának citoplazmatikus funkciói = Cytoplasmic functions of Importin-alpha2, a factor of nuclear protein import [PDF]

, 2011
Az importin-alfa2D14 + / + importin-ßKetelRE34 Drosophila nőstényektől származó embriók letálisak. Jellemeztük a maternális interakciót. Főbb eredményeink: - embrió letalitás a szinciciális blasztoderma állapotban a metafázisban blokkolt osztódási orsó
Kiss, István, Szlanka, Tamás
core  

RPGR-associated retinopathy: clinical features, molecular genetics, animal models and therapeutic options [PDF]

, 2016
Retinitis pigmentosa GTPase regulator (RPGR) gene sequence variants account for the vast majority of X linked retinitis pigmentosa (RP), which is one of the most severe forms of RP.
Hardcastle, AJ, Michaelides, M, Smith, AJ, Tee, JJ   +3 more
core   +1 more source

The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA

eLife, 2014
The HIV Rev protein routes viral RNAs containing the Rev Response Element (RRE) through the Crm1 nuclear export pathway to the cytoplasm where viral proteins are expressed and genomic RNA is delivered to assembling virions.
David S Booth, Yifan Cheng, Alan D Frankel   +2 more
doaj   +1 more source

Origin of the nucleus and Ran-dependent transport to safeguard ribosome biogenesis in a chimeric cell [PDF]

, 2008
Background: The origin of the nucleus is a central problem about the origin of eukaryotes. The common ancestry of nuclear pore complexes (NPC) and vesicle coating complexes indicates that the nucleus evolved via the modification of a pre-existing ...
Gáspár Jékely
core   +1 more source

CRM1 regulates androgen receptor stability and impacts DNA repair pathways in prostate cancer, independent of the androgen receptor

The FASEB Journal, Volume 39, Issue 2, 31 January 2025.
Prostate cancer demonstrates significantly elevated levels of CRM1 expression. Inhibition of CRM1 by Selinexor leads to a decrease in androgen receptor (AR) transcript and protein. We demonstrate that CRM1 regulates the nuclear export of HSP90, a key chaperone that regulates the stability of AR protein.
Rajendra Kumar, Janet Mendonca, Abhishek Shetty, Yuhan Yang, Olutosin Owoyemi, Lillian Wilson, Kavya Boyapati, Deven Topiwala, Naiju Thomas, Huong Nguyen, Jun Luo, Channing J. Paller, Samuel R. Denmeade, Michael A. Carducci, Sushant K. Kachhap   +14 more
wiley   +1 more source

Antileukemic Activity of Nuclear Export Inhibitors that Spare Normal Hematopoietic Cells [PDF]

, 2012
Drugs that target the chief mediator of nuclear export, chromosome region maintenance 1 protein (CRM1) have potential as therapeutics for leukemia, but existing CRM1 inhibitors show variable potencies and a broad range of cytotoxic effects.
Barcelo, C, Chook, Y M, Christie, A L, Etchin, Julia, Farmer, A, Kauffman, M, Kentsis, Alex, Kung, A L, Look, A. Thomas, Mansour, M R, McCauley, D, Rodig, Scott J., Sanda, Takaomi, Shacham, S, Sun, Q, Zhang, Z C   +15 more
core   +1 more source

Examining the Role of Matrix Metalloproteinase‐2 and MicroRNAs Regulation in Breast Cancer

The Breast Journal, Volume 2025, Issue 1, 2025.
Matrix metalloproteinase (MMPs) is a class of zinc‐dependent enzymes that play an important role in the invasion and metastasis of cancer cells and have different types. MMP‐2 is one of the important enzymes of this family. MicroRNAs (miRNAs) are noncoding RNAs that are involved in the regulation of gene expression of many enzymes and factors in the ...
Elmira Aboutalebi Vand Beilankouhi, Niloufar Kheradi, Yosra Vaez-Gharamaleki, Salomeh Roshani, Sana Abbasi, Reza Safaralizadeh, Mohammad Valilo, Guan-Jun Yang   +7 more
wiley   +1 more source

The Small GTPase Ran Increases Sensitivity of Ovarian Cancer Cells to Oncolytic Vesicular Stomatitis Virus

Pharmaceuticals
Background/Objectives: Ovarian cancer is the deadliest gynecologic cancer, and with the majority of patients dying within the first five years of diagnosis, new therapeutic options are required.
Karen Geoffroy, Mélissa Viens, Emma Mary Kalin, Zied Boudhraa, Dominic Guy Roy, Jian Hui Wu, Diane Provencher, Anne-Marie Mes-Masson, Marie-Claude Bourgeois-Daigneault   +8 more
doaj   +1 more source