Results 111 to 120 of about 3,517 (188)

Representative immunofluorescence images comparing RanGTP levels in control and CFDP1 siRNA-treated NIH3T3 cells. Related to Fig 7.

(A) RanGTP was detected using an antibody directed against the active form of Ran after 72 h of siRNA treatment. (B) Quantitation of RanGTP signal intensity in control and CFDP1 siRNA-treated cells.
Qian Xu (119888), Xianghong Luan (255495), Gokul Gopinathan (7930679), Thomas G. H. Diekwisch (7469093)   +3 more
core   +1 more source

Roles of Tubulin Concentration during Prometaphase and Ran-GTP during Anaphase of Caenorhabditis elegans Meiosis

Life Science Alliance
Tubulin dimers concentrate within an ER spindle envelope because cytoplasmic organelles outside the envelope occupy significant volume. In many animal species, the oocyte meiotic spindle, which is required for chromosome segregation, forms without ...
Ting Gong, Karen L McNally, Siri Konanoor, Alma Peraza, Cynthia Bailey, Stefanie Redemann, Francis J McNally   +6 more
doaj   +1 more source

Reduction of exportin 6 activity leads to actin accumulation via failure of RanGTP restoration and NTF2 sequestration in the nuclei of senescent cells

, 2011
We have previously reported that G-actin accumulation in nuclei is a universal phenomenon of cellular senescence. By employing primary culture of human diploid fibroblast (HDF) and stress-induced premature senescence (SIPS), we explored whether the ...
Su Hyun Park, Tae Jun Park, In Kyoung Lim, Park, SH, Lim, IK, Park, TJ   +5 more
core   +1 more source

Interaction of region B with RanGTP.

, 2015
A. Yeast two hybrid screening. Left panel, schematic representation of the bait, the Bt region of Mm_Nemp1 (DBD-Mm_Bt). Right panels, colony formation (in duplicate) of yeast AH109 cells transformed with DBD (upper) or DBD-Mm_Bt (lower) with AD-Mm_Ran on
Hiroshi Mamada (735469), Takashi Shibano (735468), Shin-Ichiro Takahashi (202755), Masanori Taira (735470), Fumihiko Hakuno (202707)   +4 more
core   +1 more source

Role of RanGTP and spindle assembly factors in cilia assembly and function

El cilio primario es una estructura formada por microtúbulos que sobresale de la superficie celular durante G0 teniendo una función de orgánulo sensor.
Mòdol Cano, Aitor
core  

Illustration of CFDP1 function in ensuring structural stability of centromeric heterochromatin and its effect on RCC1-mediated generation of RanGTP levels.

(A) CFDP1 binds to minor and major satellite heterochromatin and stabilizes a condensed chromatin architecture featuring normal H2A.Z chromatin levels and HP1α binding to H3K9me3 histone modifications. Chromatin bound RCC1 maintains high levels of RanGTP
Qian Xu (119888), Xianghong Luan (255495), Gokul Gopinathan (7930679), Thomas G. H. Diekwisch (7469093)   +3 more
core   +1 more source

Ran-GTP assembles a specialized spindle structure for accurate chromosome segregation in medaka early embryos

Nature Communications
Despite drastic cellular changes during cleavage, a mitotic spindle assembles in each blastomere to accurately segregate duplicated chromosomes. Mechanisms of mitotic spindle assembly have been extensively studied using small somatic cells.
Ai Kiyomitsu, Toshiya Nishimura, Shiang Jyi Hwang, Satoshi Ansai, Masato T. Kanemaki, Minoru Tanaka, Tomomi Kiyomitsu   +6 more
doaj   +1 more source

Understanding RanGTP dependent microtubule assembly : Idenification of DnaJB6 as a RanGTP regulated factor involved in microtubule organization during mitosis

, 2018
Three microtubule (MT) assembly pathways participate in the assembly of the bipolar spindle: the centrosomal pathway, the augmin dependent amplification pathway and the RanGTP/chromosome dependent pathway. To form the spindle, all these MTs are organized by various classes of motor proteins into two interdigitating antiparallel arrays with their minus ...
openaire   +1 more source

Mechanism of RanGTP dependent microtubule assembly during mitosis

, 2015
Programa de doctorat en ...
openaire   +1 more source

Signaling into the nucleus through the importin 7 pathway. [PDF]

J Biol Chem
Palchevska O, Ko YH, Cingolani G.
europepmc   +1 more source