Results 101 to 110 of about 6,495 (196)

Components and regulation of nuclear transport processes [PDF]

, 2015
The spatial separation of DNA replication and gene transcription in the nucleus and protein translation in the cytoplasm is a uniform principle of eukaryotic cells. This compartmentalization imposes a requirement for a transport network of macromolecules
Alefantis, Argentaro, Arnaoutov, Arts, Arts, Askjaer, Bardina, Bayliss, Beals, Beck, Bednenko, Beg, Belov, Bernad, Bischoff, Bogerd, Bohnsack, Bohnsack, Bono, Bourne, Brickner, Bui, Bunn, Calado, Callan, Caly, Capelson, Carmody, Castello, Cautain, Chen, Chook, Ciufo, Conti, Conti, Cook, Cour, Craig, Cronshaw, Debler, Devos, Dingwall, Dong, Dong, Dorfman, Englmeier, Erickson, Erkmann, Ertel, Feng, Ferrigno, Field, Fineberg, Fischer, Fontoura, Fornerod, Fornerod, Frey, Frey, Fried, Frieman, Fu, Fu, Fukuda, Fukuda, Gadal, Ghildyal, Goldfarb, Gontan, Gorlich, Gorlich, Grespin, Grossman, Gustin, Gustin, Guttler, Hall, Harel, Hellmuth, Henderson, Hill, Hill, Ho, Hoelz, Holaska, Hopper, Huang, Huber, Hubner, Hung, Hussain, Hutten, Hutten, Isgro, Izaurralde, Kalab, Kalderon, Kalderon, Katahira, Kehlenbach, Kehlenbach, Kobbe, Kohler, Komeili, Kopecky-Bromberg, Kosugi, Kosugi, Kosugi, Krull, Kunzler, Kunzler, Kurisaki, Kutay, Kutay, Lam, Lange, Lange, Lange, Lee, Lee, Lidsky, Lim, Lim, Lim, Lim, Lindsay, Long, Luna, Lund, Macara, Maimon, Makkerh, Malik, Malim, Malim, Malim, Malim, Marfori, Mateo, Maurer, Melchior, Melcák, Mingot, Mingot, Mitchell, Monecke, Moore, Moore, Mor, Mosammaparast, Murdoch, Nemergut, Neumann, Ohno, Ossareh-Nazari, Paraskeva, Park, Peters, Porter, Prieto, Ren, Rexach, Ribbeck, Richards, Riviere, Rodriguez, Rodriguez-Navarro, Rouquette, Rout, Rout, Sarma, Schwartz, Shabman, Shin, Shuai, Siddiqui, Solsbacher, Sorokin, Speese, Stade, Stommel, Strambio-De-Castillia, Suel, Therizols, Thomas, Traenckner, Tran, Truant, Turner, Turner, Vosse, Wagstaff, Walther, Watters, Weighardt, Wen, Wen, Wente, Wild, Xu, Xu, Yang, Yi, Zanella   +203 more
core   +1 more source

Probing the extent of importin‐α targeting of the TAF8 NLS by eliminating its cationic net‐charge

Protein Science, Volume 34, Issue 9, September 2025.
Abstract The nucleus, as the control center of the eukaryotic cell, is a prime target for therapeutic interventions due to its role in regulating genetic material. Importin‐α is critical for successful nuclear import as it recognizes and binds to cargo proteins bearing a classical nuclear localization signal (NLS), which facilitates their transport ...
Amirabbas Abdoli, Zhihan Yang, Abdullah Odeh‐Ahmed, Olga Bednova, Bruno Lemieux, Leanne Dawe, Aymeric Ravel‐Chapuis, Pierre Lavigne, Natalie Zeytuni, Jeffrey V. Leyton   +9 more
wiley   +1 more source

RanGTP-Binding Protein NXT1 Facilitates Nuclear Export of Different Classes of RNA In Vitro [PDF]

Molecular and Cellular Biology, 2000
To better characterize the mechanisms responsible for RNA export from the nucleus, we developed an in vitro assay based on the use of permeabilized HeLa cells. This new assay supports nuclear export of U1 snRNA, tRNA, and mRNA in an energy- and Xenopus extract-dependent manner.
B, Ossareh-Nazari, C, Maison, B E, Black, L, Lévesque, B M, Paschal, C, Dargemont   +5 more
openaire   +2 more sources

Nuclear-cytoplasmic trafficking of NTF2, the nuclear import receptor for the RanGTPase, is subjected to regulation. [PDF]

PLoS ONE, 2012
NTF2 is a cytosolic protein responsible for nuclear import of Ran, a small Ras-like GTPase involved in a number of critical cellular processes, including cell cycle regulation, chromatin organization during mitosis, reformation of the nuclear envelope ...
Shawn C Chafe, Jacqueline B Pierce, Dev Mangroo   +2 more
doaj   +1 more source

Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle [PDF]

, 2017
The Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is a sequence-specific DNA binding protein which plays an essential role in viral episome replication and segregation, by recruiting the cellular complex of DNA replication onto the origin (oriP) and
Baillie, George S., Deschamps, Thibaut, Gruffat, Henri, Leske, Derek M., Lotteau, Vincent, MacLeod, Ruth, Manet, Evelyne, Maréchal, Vincent, Mompelat, Dimitri, Quentin, Bazot, Tafforeau, Lionel, Wilson, Joanna B.   +11 more
core   +3 more sources

Chromenone Derivatives as CRM1 Inhibitors for Targeting Glioblastoma

ChemBioChem, Volume 26, Issue 15, August 22, 2025.
Chromenone derivatives are synthesized and evaluated as inhibitors of chromosome region maintenance 1‐mediated nuclear export, targeting glioblastoma cells. Active compounds demonstrate structure‐ and dose‐dependent inhibition, supported by structure–activity relationships and molecular docking studies.
Salvatore Princiotto, Lucía Jiménez, Lucía Domínguez, João G. N. Sequeira, Cristiana Mourato, Alba Orea‐Soufi, Bruno Santos, Sabrina Dallavalle, Miguel Machuqueiro, Bibiana I. Ferreira, Wolfgang Link   +10 more
wiley   +1 more source

Spindle Assembly in the Absence of a RanGTP Gradient Requires Localized CPC Activity [PDF]

Current Biology, 2009
During animal cell division, a gradient of GTP-bound Ran is generated around mitotic chromatin [1, 2]. It is generally accepted that this RanGTP gradient is essential for organizing the spindle since it locally activates critical spindle assembly factors [3–5].
Maresca, Thomas J., Groen, Aaron C., Gatlin, Jesse C., Ohi, Ryoma, Mitchison, Timothy J., Salmon, Edward D.   +5 more
openaire   +2 more sources

Importin α5 negatively regulates importin β1-mediated nuclear import of Newcastle disease virus matrix protein and viral replication and pathogenicity in chicken fibroblasts

Virulence, 2018
The matrix (M) protein of Newcastle disease virus (NDV) is demonstrated to localize in the nucleus via intrinsic nuclear localization signal (NLS), but cellular proteins involved in the nuclear import of NDV M protein and the role of M's nuclear ...
Zhiqiang Duan, Haixu Xu, Xinqin Ji, Jiafu Zhao, Houqiang Xu, Yan Hu, Shanshan Deng, Shunlin Hu, Xiufan Liu   +8 more
doaj   +1 more source

Centromere Protein F in Tumor Biology: Cancer's Achilles Heel

Cancer Medicine, Volume 14, Issue 10, May 2025.
ABSTRACT Background Centromere protein F (CENP‐F) is an important nuclear matrix protein that regulates mitosis and the cell cycle, and plays a crucial role in recruiting spindle checkpoint proteins to maintain the accuracy of chromosome segregation.
Zitong Wan, Miaomiao Wen, Chunlong Zheng, Ying Sun, Yinxi Zhou, Yahui Tian, Shaowei Xin, Xuejiao Wang, Xiaohong Ji, Jie Yang, Yanlu Xiong, Yong Han   +11 more
wiley   +1 more source

Identification of different roles for RanGDP and RanGTP in nuclear protein import. [PDF]

The EMBO Journal, 1996
The importin-alpha/beta heterodimer and the GTPase Ran play key roles in nuclear protein import. Importin binds the nuclear localization signal (NLS). Translocation of the resulting import ligand complex through the nuclear pore complex (NPC) requires Ran and is terminated at the nucleoplasmic side by its disassembly.
Görlich, D., Pante, N., Kutay, U., Aebi, U., Bischoff, F.   +4 more
openaire   +3 more sources