Results 101 to 110 of about 3,517 (188)

Steady-State Nuclear Localization of Exportin-t Involves RanGTP Binding and Two Distinct Nuclear Pore Complex Interaction Domains

, 2002
Vertebrate tRNA export receptor exportin-t (Xpo-t) binds to RanGTP and mature tRNAs cooperatively to form a nuclear export complex. Xpo-t shuttles bidirectionally through nuclear pore complexes (NPCs) but is mainly nuclear at steady state.
Scott Kuersten, Ludwig Englmeier, Iain W. Mattaj, Gert-Jan Arts, Tobias C. Walther   +4 more
core   +1 more source

Identifizierung und Charakterisierung eines neuen RanGTP-bindenden Proteins in der Hefe Saccharomyces cerevisiae [PDF]

, 2002
Der kleinen GTPase Ran kommt in interphasischen Zellen eine zentrale Rolle beim Transport von Molekülen durch die Kernmembran zu.In höheren eukary- ontischen Zellen zerfällt während der Prometaphase der Mitose die Kern- membran.Es konnte neuerdings ...
Braunwarth, Andreas Benedict
core   +1 more source

Crystal structure of human CRM1, covalently modified by 2‐mercaptoethanol on Cys528, in complex with RanGTP

, 2021
CRM1 is a nuclear export receptor that has been intensively targeted over the last decade for the development of antitumor and antiviral drugs. Structural analysis of several inhibitor compounds bound to CRM1 revealed that their mechanism of action ...
Ficner, Ralf, Schmitt, Kerstin; 2Department of Molecular Microbiology and Genetics, Georg-August-Universität Göttingen, Grisebachstrasse 8, 37077Göttingen, Germany, Valerius, Oliver; 2Department of Molecular Microbiology and Genetics, Georg-August-Universität Göttingen, Grisebachstrasse 8, 37077Göttingen, Germany, Shaikhqasem, Alaa, Schmitt, Kerstin, Shaikhqasem, Alaa; 1Department for Molecular Structural Biology, Georg-August-Universität Göttingen, Justus-von-Liebig Weg 11, 37077Göttingen, Germany, Valerius, Oliver   +6 more
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Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP [PDF]

, 2010
The biogenesis, maintenance and function of primary cilia are controlled through intraflagellar transport (IFT) driven by two kinesin-2 family members, the heterotrimeric KIF3A/KIF3B/KAP complex and the homodimeric KIF17 motor. How these motors and their
Martens, Jeffrey R, Hooi Lynn Kee, Jennetta W. Hammond, Kee, Hooi Lynn, Ben Margolis, Margolis, Ben, Shuling Fan, Yen Nhu-Thi Truong, Truong, Yen Nhu-Thi, Verhey, Kristen J, Toby W. Hurd, Dishinger, John F, Kristen J. Verhey, Jeffrey R. Martens, Hurd, Toby W, Hammond, Jennetta W, Paul M. Jenkins, Fan, Shuling, John F. Dishinger, Jenkins, Paul M   +19 more
core   +1 more source

Identification and Characterization of a Novel RanGTP-binding Protein in the Yeast Saccharomyces cerevisiae

, 2003
International audienceThe small Ras-like GTPase Ran plays an essential role in the transport of macromolecules in and out of the nucleus and has been implicated in spindle (1,2 ) and nuclear envelope formation (3,4 ) during mitosis in higher eukaryotes ...
Gerstberger, Thomas, Künzler, Markus, Bischoff, F. Ralf, Legrain, Pierre, Fromont-Racine, Micheline, Braunwarth, Andreas, Hurt, Ed   +6 more
core   +1 more source

Animal Female Meiosis: The Challenges of Eliminating Centrosomes

Cells, 2018
Sexual reproduction requires the generation of gametes, which are highly specialised for fertilisation. Female reproductive cells, oocytes, grow up to large sizes when they accumulate energy stocks and store proteins as well as mRNAs to enable rapid cell
Oliver J. Gruss
doaj   +1 more source

The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus. [PDF]

, 1997
The GTPase Ran is essential for nuclear import of proteins with a classical nuclear localization signal (NLS). Ran's nucleotide‐bound state is determined by the chromatin‐bound exchange factor RCC1 generating RanGTP in the nucleus and the cytoplasmic ...
Izaurralde, E., Izaurralde, Elisa, Kutay, Ulrike, Görlich, Dirk, Kutay, U., Von Kobbe Alonso, Cayetano, Mattay, I., Görlich, D., von Kobbe, C., Mattaj, Iain W.   +9 more
core   +1 more source

Mechanism of RanGTP dependent microtubule assembly during mitosis

During mitosis, spindle assembly involves different sources of microtubules including centrosomes and chromosomes. While the role of centrosomes has been extensively studied, we still do not fully understand how chromosomes trigger microtubule assembly ...
Scrofani, Jacopo
core  

Influenza virus ribonucleoprotein complexes gain preferential access to cellular export machinery through chromatin targeting.

PLoS Pathogens, 2011
In contrast to most RNA viruses, influenza viruses replicate their genome in the nucleus of infected cells. As a result, newly-synthesized vRNA genomes, in the form of viral ribonucleoprotein complexes (vRNPs), must be exported to the cytoplasm for ...
Geoffrey P Chase, Marie-Anne Rameix-Welti, Aurelija Zvirbliene, Gintautas Zvirblis, Veronika Götz, Thorsten Wolff, Nadia Naffakh, Martin Schwemmle   +7 more
doaj   +1 more source

Understanding RanGTP dependent microtubule assembly : Idenification of DnaJB6 as a RanGTP regulated factor involved in microtubule organization during mitosis

Three microtubule (MT) assembly pathways participate in the assembly of the bipolar spindle: the centrosomal pathway, the augmin dependent amplification pathway and the RanGTP/chromosome dependent pathway. To form the spindle, all these MTs are organized
Rosas Salvans, Miquel
core