Results 81 to 90 of about 6,495 (196)

Das endogene Retrovirus HTDV/HERV-K: Untersuchungen zur Funktion des akzessorischen Proteins Rec [PDF]

, 2004
Retroviren benutzen für die Transkription und Translation ihrer Gene den zellulären Transkriptions– und Translationsapparat. In eukaryotischen Zellen wird die RNA nach der Transkription prozessiert, erst danach verlässt sie den Kern.
Hahn, Silvia, Renkawitz-Pohl, Renate (Prof.)   +1 more
core   +1 more source

Phosphorylation of Maskin by Aurora-A Is Regulated by RanGTP and Importin β [PDF]

Journal of Biological Chemistry, 2006
Mitotic spindle assembly in Xenopus egg extracts is regulated at least in part by importin beta and its regulator, the small GTPase, Ran. RanGTP stabilizes microtubules near the chromosomes during spindle assembly by selectively releasing spindle assembly factors from inhibition by importin alpha/beta in the vicinity of the chromosomes. Several spindle
Alison J, Albee, Wei, Tao, Christiane, Wiese   +2 more
openaire   +2 more sources

Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors [PDF]

, 2013
Nucleocytoplasmic transport is mediated by nuclear pore complexes (NPCs) embedded in the nuclear envelope. About 30 different proteins (nucleoporins, nups) arrange around a central eightfold rotational axis to build the modular NPC. Nup188 and Nup192 are
Adam, Adams, Aitchison, Alber, Allen, Amlacher, Aravind, Bailer, Bayliss, Bayliss, Bednenko, Berka, Berke, Bilokapic, Brohawn, Brohawn, Brohawn, Capelson, Chook, Conti, Cook, Cronshaw, Devos, Dultz, D’Angelo, Emsley, Finlay, Flemming, Floer, Grandi, Grossman, Görlich, Hedges, Holm, Hülsmann, Jeudy, Kampmann, Leksa, Levy, Li, Lowe, Lutzmann, Mans, Marelli, McCoy, Menendez-Benito, Mohr, Nachury, Nachury, Nehrbass, Neumann, Onischenko, Onischenko, Otwinowski, Patel, Pyhtila, Rabut, Reichelt, Ren, Rout, Saksela, Savas, Schrader, Sheldrick, Theerthagiri, Weis, Weiss, Whittle, Winn, Xu, Yamada   +70 more
core   +2 more sources

Structural Insights Into the Nuclear Import of Gallid Alphaherpesvirus 1 Large Tegument Protein

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
The study identifies and characterizes a bipartite nuclear localization signal within the GaAHV‐1 UL36 large tegument protein, revealing its structural interaction with importin α/β1 and confirming a conserved mechanism of nuclear import through biochemical, crystallographic, and mutational analyses.
Babu Kanti Nath, Crystall M. D. Swarbrick, Reuben Blades, Daryl Ariawan, Ole Tietz, Gualtiero Alvisi, Jade K. Forwood, Subir Sarker   +7 more
wiley   +1 more source

Human RanBP3, a group of nuclear RanGTP binding proteins¹ [PDF]

FEBS Letters, 1998
A group of novel human Ran‐binding proteins, RanBP3, was identified using the yeast two‐hybrid system via Ran‐mediated interaction with the nucleotide exchange factor RCC1. Several open reading frames, representing putative alternatively spliced products, were established by cDNA cloning.
Liz Mueller, Volker C Cordes*, F.Ralf Bischoff, Herwig Ponstingl   +3 more
openaire   +1 more source

Thioredoxin-related transmembrane protein 2 (TMX2) regulates the Ran protein gradient and importin-β-dependent nuclear cargo transport

Scientific Reports, 2019
TMX2 is a thioredoxin family protein, but its functions have not been clarified. To elucidate the function of TMX2, we explored TMX2-interacting proteins by LC-MS. As a result, importin-β, Ran GTPase (Ran), RanGAP, and RanBP2 were identified.
Ami Oguro, Susumu Imaoka
doaj   +1 more source

Anaplasma phagocytophilum Ankyrin A Protein (AnkA) Enters the Nucleus Using an Importin-β-, RanGTP-Dependent Mechanism

Frontiers in Cellular and Infection Microbiology, 2022
Anaplasma phagocytophilum, a tick-borne obligately intracellular bacterium of neutrophils, causes human granulocytic anaplasmosis. Ankyrin A (AnkA), an effector protein with multiple ankyrin repeats (AR) is injected via type IV-secretion into the host ...
Yuri Kim, Yuri Kim, Jianyang Wang, Jianyang Wang, Emily G. Clemens, Dennis J. Grab, J. Stephen Dumler   +6 more
doaj   +1 more source

Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP [PDF]

, 2010
The biogenesis, maintenance, and function of primary cilia are controlled through intraflagellar transport (IFT) driven by two kinesin-2 family members, the heterotrimeric KIF3A/KIF3B/KAP complex and the homodimeric KIF17 motor1,2.
Dishinger, John F, Fan, Shuling, Hammond, Jennetta W, Hurd, Toby W, Jenkins, Paul M, Kee, Hooi Lynn, Margolis, Ben, Martens, Jeffrey R, Truong, Yen Nhu-Thi, Verhey, Kristen J   +9 more
core   +2 more sources

The importin‐alpha superfamily engages in ethylene signaling by shuttling ETHYLENE INSENSITIVE 2 from the endoplasmic reticulum to the nucleus

The FEBS Journal, Volume 293, Issue 3, Page 894-917, February 2026.
The plant hormone ethylene regulates plant growth, ripening, senescence, and stress responses. The hormonal signal transmission, from receptors at the ER membrane to the transcriptional regulators in the nucleus, is still not completely understood.
Fabian Wynen, Jan Eric Maika, Raphael Josef Eberle, Nina Jahnke, Marcel Wiermer, Laura Hartmann, Rüdiger Simon, Georg Groth   +7 more
wiley   +1 more source

CHD4 Is a RanGTP-Dependent MAP that Stabilizes Microtubules and Regulates Bipolar Spindle Formation [PDF]

Current Biology, 2013
Production of the GTP-bound form of the Ran GTPase (RanGTP) around chromosomes induces spindle assembly by activating nuclear localization signal (NLS)-containing proteins. Several NLS proteins have been identified as spindle assembly factors, but the complexity of the process led us to search for additional proteins with distinct roles in spindle ...
Koffa, Maria, Yokoyama, Hideki, Nakos, Konstantinos, Santarella-Mellwig, Rachel, Rybina, Sofia, Krijgsveld, Jeroen, Mattaj, Iain W.   +6 more
openaire   +3 more sources