Results 81 to 90 of about 3,517 (188)
Supraphysiological nuclear export signals bind CRM1 independently of RanGTP and arrest at Nup358 [PDF]
The EMBO Journal, 2004 Leucine-rich nuclear export signals (NESs) mediate rapid nuclear export of proteins via interaction with CRM1. This interaction is stimulated by RanGTP but remains of a relatively low affinity. In order to identify strong signals, we screened a 15-mer random peptide library for CRM1 binding, both in the presence and absence of RanGTP.
Dieuwke, Engelsma +3 more
openaire +2 more sources
A RanGTP-independent mechanism allows ribosomal protein nuclear import for ribosome assembly
eLife, 2014 Within a single generation time a growing yeast cell imports ∼14 million ribosomal proteins (r-proteins) into the nucleus for ribosome production. After import, it is unclear how these intrinsically unstable and aggregation-prone proteins are targeted to
Sabina Schütz +10 more
doaj +1 more source
The FEBS Journal, Volume 293, Issue 3, Page 894-917, February 2026.The plant hormone ethylene regulates plant growth, ripening, senescence, and stress responses. The hormonal signal transmission, from receptors at the ER membrane to the transcriptional regulators in the nucleus, is still not completely understood.
Fabian Wynen +7 more
wiley +1 more source
Where, When, and How? Integrating Spatiotemporal Cues in Cell Division
BioEssays, Volume 48, Issue 1, January 2026.Accurate chromosome segregation during mitosis depends on the spatial and temporal regulation of spindle assembly, kinetochore‐microtubule attachment, and checkpoint signaling. Here, we highlight how mitotic chromosomes can serve as dynamic hubs that integrate molecular cues to coordinate spindle organization and timing, ensuring faithful genome ...
Luca Cirillo +3 more
wiley +1 more source
Virulence, 2018 The matrix (M) protein of Newcastle disease virus (NDV) is demonstrated to localize in the nucleus via intrinsic nuclear localization signal (NLS), but cellular proteins involved in the nuclear import of NDV M protein and the role of M's nuclear ...
Zhiqiang Duan +8 more
doaj +1 more source
Nuclear-cytoplasmic trafficking of NTF2, the nuclear import receptor for the RanGTPase, is subjected to regulation. [PDF]
PLoS ONE, 2012 NTF2 is a cytosolic protein responsible for nuclear import of Ran, a small Ras-like GTPase involved in a number of critical cellular processes, including cell cycle regulation, chromatin organization during mitosis, reformation of the nuclear envelope ...
Shawn C Chafe +2 more
doaj +1 more source
The NLS3 Motif in TPX2 Regulates Spindle Architecture in Xenopus Egg Extracts
Cytoskeleton, Volume 83, Issue 1, Page 29-39, January 2026.ABSTRACT A bipolar spindle composed of microtubules and many associated proteins functions to segregate chromosomes during cell division in all eukaryotes, yet both spindle size and architecture vary dramatically across different species and cell types.
Guadalupe E. Pena +4 more
wiley +1 more source
Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.ABSTRACT Background Multinucleation occurs at high frequency during the first mitosis of human embryos and is associated with impaired developmental potential. Our live‐imaging analyses showed that collapse of spindle geometry—such as low‐aspect ratio spindles and pole defocusing—correlates with multinucleation, yet molecular links from aberrant ...
Yuki Ono, Yukihiro Terada
wiley +1 more source
PLoS BiologyThe densely packed centromeric heterochromatin at minor and major satellites is comprised of H3K9me2/3 histones, the heterochromatin protein HP1α, and histone variants.
Gokul Gopinathan +3 more
doaj +1 more source
Crosstalk between the actin cytoskeleton and Ran-mediated nuclear transport
BMC Cell Biology, 2005 Background Transport of macromolecules into and out of the nucleus is a highly regulated process. The RanGTP/RanGDP gradient controls the trafficking of molecules exceeding the diffusion limit of the nuclear pore across the nuclear envelope.
Steward Ruth +3 more
doaj +1 more source