Results 51 to 60 of about 3,517 (188)
RanGTP aids anaphase entry through Ubr5-mediated protein turnover [PDF]
Journal of Cell Biology, 2015 RanGTP is known to regulate the spindle assembly checkpoint (SAC), but the underlying molecular mechanism is unclear. BuGZ stabilizes SAC protein Bub3 through direct interaction and facilitates its mitotic function. Here we show that RanGTP promotes the turnover of BuGZ and Bub3 in metaphase, which in turn facilitates metaphase-to-anaphase transition ...
Jiang, Hao +4 more
openaire +2 more sources
Cell Reports, 2016 The karyopherin (Kap) family of nuclear transport factors facilitates macromolecular transport through nuclear pore complexes (NPCs). The binding of Kaps to their cargos can also regulate, both temporally and spatially, the interactions of the cargo ...
Lucas V. Cairo, Richard W. Wozniak
doaj +1 more source
Spindle assembly in the absence of a RanGTP gradient requires localized CPC activity [PDF]
, 2009 Author Posting. © The Author(s), 2009. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution.
Mitchison, Timothy J. +11 more
core +1 more source
Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone
eLife, 2019 We report the crystal structure of nuclear import receptor Importin-9 bound to its cargo, the histones H2A-H2B. Importin-9 wraps around the core, globular region of H2A-H2B to form an extensive interface.
Abhilash Padavannil +9 more
doaj +1 more source
Conservation of complex nuclear localization signals utilizing classical and non-classical nuclear import pathways in LANA homologs of KSHV and RFHV. [PDF]
PLoS ONE, 2011 ORF73 latency-associated nuclear antigen (LANA) of the Kaposi's sarcoma-associated herpesvirus (KSHV) is targeted to the nucleus of infected cells where it binds to chromatin and mediates viral episome persistence, interacts with cellular proteins and ...
Lidia Cherezova +2 more
doaj +1 more source
Comparative genomics of proteins involved in RNA nucleocytoplasmic export
BMC Evolutionary Biology, 2011 Background The establishment of the nuclear membrane resulted in the physical separation of transcription and translation, and presented early eukaryotes with a formidable challenge: how to shuttle RNA from the nucleus to the locus of protein synthesis ...
Goldenberg Samuel +4 more
doaj +1 more source
The nuclear lamina is a hub for the nuclear function of Jacob
Molecular Brain, 2021 Jacob is a synapto-nuclear messenger protein that couples NMDAR activity to CREB-dependent gene expression. In this study, we investigated the nuclear distribution of Jacob and report a prominent targeting to the nuclear envelope that requires NMDAR ...
Sebastian Samer +4 more
doaj +1 more source
The interaction of CRM1 and the nuclear pore protein Tpr.
PLoS ONE, 2014 While much has been devoted to the study of transport mechanisms through the nuclear pore complex (NPC), the specifics of interactions and binding between export transport receptors and the NPC periphery have remained elusive.
Charles L Zhao +3 more
doaj +1 more source
The Multifaceted Roles of RCC1 in Tumorigenesis
Frontiers in Molecular Biosciences, 2020 RCC1 (regulator of chromosome condensation 1) is the only known guanine nucleotide exchange factor of Ran, a nuclear Ras-like G protein. RCC1 combines with chromatin and Ran to establish a concentration gradient of RanGTP, thereby participating in a ...
Xuanqi Ren, Kai Jiang, Feng Zhang
doaj +1 more source
Advanced Materials, EarlyView.Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello +5 more
wiley +1 more source