Results 51 to 60 of about 3,329 (143)

Structural Insights Into the Nuclear Import of Gallid Alphaherpesvirus 1 Large Tegument Protein

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
The study identifies and characterizes a bipartite nuclear localization signal within the GaAHV‐1 UL36 large tegument protein, revealing its structural interaction with importin α/β1 and confirming a conserved mechanism of nuclear import through biochemical, crystallographic, and mutational analyses.
Babu Kanti Nath, Crystall M. D. Swarbrick, Reuben Blades, Daryl Ariawan, Ole Tietz, Gualtiero Alvisi, Jade K. Forwood, Subir Sarker   +7 more
wiley   +1 more source

The importin‐alpha superfamily engages in ethylene signaling by shuttling ETHYLENE INSENSITIVE 2 from the endoplasmic reticulum to the nucleus

The FEBS Journal, Volume 293, Issue 3, Page 894-917, February 2026.
The plant hormone ethylene regulates plant growth, ripening, senescence, and stress responses. The hormonal signal transmission, from receptors at the ER membrane to the transcriptional regulators in the nucleus, is still not completely understood.
Fabian Wynen, Jan Eric Maika, Raphael Josef Eberle, Nina Jahnke, Marcel Wiermer, Laura Hartmann, Rüdiger Simon, Georg Groth   +7 more
wiley   +1 more source

Where, When, and How? Integrating Spatiotemporal Cues in Cell Division

BioEssays, Volume 48, Issue 1, January 2026.
Accurate chromosome segregation during mitosis depends on the spatial and temporal regulation of spindle assembly, kinetochore‐microtubule attachment, and checkpoint signaling. Here, we highlight how mitotic chromosomes can serve as dynamic hubs that integrate molecular cues to coordinate spindle organization and timing, ensuring faithful genome ...
Luca Cirillo, Hradini Konthalapalli, Claudio Alfieri, Jonathon Pines   +3 more
wiley   +1 more source

The NLS3 Motif in TPX2 Regulates Spindle Architecture in Xenopus Egg Extracts

Cytoskeleton, Volume 83, Issue 1, Page 29-39, January 2026.
ABSTRACT A bipolar spindle composed of microtubules and many associated proteins functions to segregate chromosomes during cell division in all eukaryotes, yet both spindle size and architecture vary dramatically across different species and cell types.
Guadalupe E. Pena, Xiao Zhou, Lauren Slevin, Christopher Brownlee, Rebecca Heald   +4 more
wiley   +1 more source

Multinucleation in the Human Embryo's First Mitosis: Linking Spindle Geometry Defects, SAC Tolerance, Chromosome Segregation, and Nuclear Envelope Reassembly

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACT Background Multinucleation occurs at high frequency during the first mitosis of human embryos and is associated with impaired developmental potential. Our live‐imaging analyses showed that collapse of spindle geometry—such as low‐aspect ratio spindles and pole defocusing—correlates with multinucleation, yet molecular links from aberrant ...
Yuki Ono, Yukihiro Terada
wiley   +1 more source

Identification and Validation of Mitophagy‐Related Biomarkers in Colorectal Cancer: An Integrated Analysis of Single‐Cell Transcriptome and Mendelian Randomization

Genetics Research , Volume 2026, Issue 1, 2026.
Mitophagy is essential for cancer formation and invasion, but its role in colorectal cancer (CRC) remains unclear. We obtained sequencing data and mitophagy‐related genes (MP‐RGs) from public databases. Differential expression analysis and weighted gene coexpression network analysis (WGCNA) identified mitophagy‐related differentially expressed genes ...
Jingyi Zhao, Meng Kong, Sining Wang, Zhixin Cao, Xiangguo Tian, Hongda Liu   +5 more
wiley   +1 more source

Prematurely Aged Human Microglia Exhibit Impaired Stress Response and Defective Nucleocytoplasmic Shuttling of ALS Associated FUS

Aging Cell, Volume 24, Issue 11, November 2025.
We developed a human microglia aging model by doxycycline‐induced GFP‐progerin expression, which offers a valuable tool to study human microglial aging and its contribution to neurodegeneration. Induced HMC3‐Progerin cells exhibited increased age markers as well as transcriptomic alterations, including an age‐associated transcriptomic shift and ...
Christiane Hartmann, Christina Haß, Muriel Knobloch, Israel Barrantes, Laura Fumagalli, Jessie Premereur, Franz Markert, Maite Peters, Georgia Koromila, Alexander Hartmann, Kathrin Jäger, Jette Abel, Renzo Mancuso, Alexander Storch, Michael Walter, Georg Fuellen, Andreas Hermann   +16 more
wiley   +1 more source

Probing the extent of importin‐α targeting of the TAF8 NLS by eliminating its cationic net‐charge

Protein Science, Volume 34, Issue 9, September 2025.
Abstract The nucleus, as the control center of the eukaryotic cell, is a prime target for therapeutic interventions due to its role in regulating genetic material. Importin‐α is critical for successful nuclear import as it recognizes and binds to cargo proteins bearing a classical nuclear localization signal (NLS), which facilitates their transport ...
Amirabbas Abdoli, Zhihan Yang, Abdullah Odeh‐Ahmed, Olga Bednova, Bruno Lemieux, Leanne Dawe, Aymeric Ravel‐Chapuis, Pierre Lavigne, Natalie Zeytuni, Jeffrey V. Leyton   +9 more
wiley   +1 more source

Chromenone Derivatives as CRM1 Inhibitors for Targeting Glioblastoma

ChemBioChem, Volume 26, Issue 15, August 22, 2025.
Chromenone derivatives are synthesized and evaluated as inhibitors of chromosome region maintenance 1‐mediated nuclear export, targeting glioblastoma cells. Active compounds demonstrate structure‐ and dose‐dependent inhibition, supported by structure–activity relationships and molecular docking studies.
Salvatore Princiotto, Lucía Jiménez, Lucía Domínguez, João G. N. Sequeira, Cristiana Mourato, Alba Orea‐Soufi, Bruno Santos, Sabrina Dallavalle, Miguel Machuqueiro, Bibiana I. Ferreira, Wolfgang Link   +10 more
wiley   +1 more source

Centromere Protein F in Tumor Biology: Cancer's Achilles Heel

Cancer Medicine, Volume 14, Issue 10, May 2025.
ABSTRACT Background Centromere protein F (CENP‐F) is an important nuclear matrix protein that regulates mitosis and the cell cycle, and plays a crucial role in recruiting spindle checkpoint proteins to maintain the accuracy of chromosome segregation.
Zitong Wan, Miaomiao Wen, Chunlong Zheng, Ying Sun, Yinxi Zhou, Yahui Tian, Shaowei Xin, Xuejiao Wang, Xiaohong Ji, Jie Yang, Yanlu Xiong, Yong Han   +11 more
wiley   +1 more source