RanGTP and CLASP1 cooperate to position the mitotic spindle [PDF]
Molecular Biology of the Cell, 2013 Accurate positioning of the mitotic spindle is critical to ensure proper distribution of chromosomes during cell division. The small GTPase Ran, which regulates a variety of processes throughout the cell cycle, including interphase nucleocytoplasmic ...
Heald, Rebecca +2 more
core +4 more sources
The strategy for coupling the RanGTP gradient to nuclear protein export [PDF]
Proceedings of the National Academy of Sciences, 2003 The Ran GTPase plays critical roles in both providing energy for and determining the directionality of nucleocytoplasmic transport. The mechanism that couples the RanGTP gradient to nuclear protein export will determine the rate of and limits to ...
Becskei, Attila +3 more
core +4 more sources
Spindle assembly in the absence of a RanGTP gradient requires localized CPC activity [PDF]
Current Biology, 2009 Author Posting. © The Author(s), 2009. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution.
Mitchison, Timothy J. +11 more
core +4 more sources
Samp1, a RanGTP binding transmembrane protein in the inner nuclear membrane [PDF]
Nucleus, 2016 Samp1 is a transmembrane protein of the inner nuclear membrane (INM), which interacts with the nuclear lamina and the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex in interphase and during mitosis, it localizes to the mitotic spindle.
Vijayaraghavan, Balaje, +3 more
core +3 more sources
Phosphorylation of maskin by Aurora-A is regulated by RanGTP and importin �� [PDF]
Journal of Biological Chemistry, 2006 Mitotic spindle assembly in Xenopus egg extracts is regulated at least in part by importin ?? and its regulator, the small GTPase, Ran. RanGTP stabilizes microtubules near the chromosomes during spindle assembly by selectively releasing spindle assembly ...
Tao, Wei +5 more
core +3 more sources
DnaJB6 is a RanGTP-regulated protein required for microtubule organization during mitosis [PDF]
Journal of Cell Science, 2019 Bipolar spindle organization is essential for the faithful segregation of chromosomes during cell division. This organization relies on the collective activities of motor proteins.
Vernos, Isabelle, 1959- +3 more
core +4 more sources
Structural basis for RanGTP independent entry of spliceosomal U snRNPs into the nucleus
Journal of Molecular Biology, 2007 The nuclear import of assembled spliceosomal subunits, the uridine rich small nuclear ribonucleoprotein particles U snRNPs , is mediated by a nuclear import receptor adaptor couple of importin amp; 946; Imp amp; 946; and snurportin1 SPN1 .
Ficner, Ralf +7 more
core +4 more sources
Identification of Two novel RanGTP-binding proteins belonging to the importin β superfamily. [PDF]
Journal of Biological Chemistry, 2000 Nucleo-cytoplasmic transport comprises a large number of distinct pathways, many of which are defined by members of the importin β superfamily of nuclear transport receptors.
Prehn, S. +11 more
core +6 more sources
Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP.
Science, 2009 CRM1 mediates nuclear export of numerous unrelated cargoes, which may carry a short leucine rich nuclear export signal or export signatures that include folded domains. How CRM1 recognizes such a variety of cargoes has been unknown up to this point. Here
Monecke, T. +11 more
core +6 more sources
RanGTP is required for meiotic spindle organization and the initiation of embryonic development inDrosophila [PDF]
Journal of Cell Science, 2011 RanGTP is important for chromosome-dependent spindle assembly in Xenopus extracts. Here we report on experiments to determine the role of the Ran pathway on microtubule dynamics in Drosophila oocytes and embryos.
J. Cesario, K. S. McKim
core +4 more sources