The RanGTP pathway: from nucleo-cytoplasmic transport to spindle assembly and beyond [PDF]
Frontiers in Cell and Developmental Biology, 2016 The small GTPase Ran regulates the interaction of transport receptors with a number of cellular cargo proteins. The high affinity binding of the GTP-bound form of Ran to import receptors promotes cargo release, whereas its binding to export receptors ...
Tommaso eCavazza +4 more
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A Novel Class of RanGTP Binding Proteins [PDF]
The Journal of Cell Biology, 1997 The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. Although Ran has been implicated also in a variety of other processes, such as cell cycle progression, a direct function ...
Prehn, S. +17 more
core +6 more sources
The strategy for coupling the RanGTP gradient to nuclear protein export [PDF]
Proceedings of the National Academy of Sciences, 2003 The Ran GTPase plays critical roles in both providing energy for and determining the directionality of nucleocytoplasmic transport. The mechanism that couples the RanGTP gradient to nuclear protein export will determine the rate of and limits to ...
Becskei, Attila +3 more
core +4 more sources
RanGTP and CLASP1 cooperate to position the mitotic spindle [PDF]
Molecular Biology of the Cell, 2013 Accurate positioning of the mitotic spindle is critical to ensure proper distribution of chromosomes during cell division. The small GTPase Ran, which regulates a variety of processes throughout the cell cycle, including interphase nucleocytoplasmic ...
Heald, Rebecca +2 more
core +5 more sources
Samp1, a RanGTP binding transmembrane protein in the inner nuclear membrane [PDF]
Nucleus, 2016 Samp1 is a transmembrane protein of the inner nuclear membrane (INM), which interacts with the nuclear lamina and the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex in interphase and during mitosis, it localizes to the mitotic spindle.
Vijayaraghavan, Balaje, +3 more
core +3 more sources
Phosphorylation of maskin by Aurora-A is regulated by RanGTP and importin �� [PDF]
Journal of Biological Chemistry, 2006 Mitotic spindle assembly in Xenopus egg extracts is regulated at least in part by importin ?? and its regulator, the small GTPase, Ran. RanGTP stabilizes microtubules near the chromosomes during spindle assembly by selectively releasing spindle assembly ...
Tao, Wei +5 more
core +3 more sources
RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase [PDF]
Molecular and Cellular Biology, 1999 CRM1 is an export receptor mediating rapid nuclear exit of proteins and RNAs to the cytoplasm. CRM1 export cargoes include proteins with a leucine- rich nuclear export signal (NES) that bind directly to CRM1 in a trimeric complex with RanGTP.
Kjems, Jørgen +10 more
core +3 more sources
RanGTP is required for meiotic spindle organization and the initiation of embryonic development inDrosophila [PDF]
Journal of Cell Science, 2011 RanGTP is important for chromosome-dependent spindle assembly in Xenopus extracts. Here we report on experiments to determine the role of the Ran pathway on microtubule dynamics in Drosophila oocytes and embryos.
J. Cesario, K. S. McKim
core +4 more sources
Identification of Two novel RanGTP-binding proteins belonging to the importin β superfamily. [PDF]
Journal of Biological Chemistry, 2000 Nucleo-cytoplasmic transport comprises a large number of distinct pathways, many of which are defined by members of the importin β superfamily of nuclear transport receptors.
Prehn, S. +11 more
core +7 more sources
The interaction of RNA helicase DDX3 with HIV-1 Rev-CRM1-RanGTP complex during the HIV replication cycle. [PDF]
PLoS ONE, 2015 Molecular traffic between the nucleus and the cytoplasm is regulated by the nuclear pore complex (NPC), which acts as a highly selective channel perforating the nuclear envelope in eukaryotic cells.
Seyed Hanif Mahboobi +2 more
doaj +2 more sources