Results 21 to 30 of about 3,830 (141)
Quantitative Nucleocytoplasmic Transport Assays in Cellular Models of Neurodegeneration
Bio-Protocol, 2020 Nucleocytoplasmic transport deficits are suggested to play a role in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Given the importance and complexity of this process, understanding when these aberrations occur and which ...
Joni Vanneste +4 more
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Adjunct Duties for Karyopherins: Regulating Septin Sumoylation [PDF]
, 2007 Karyopherins are shuttling transport receptors regulated by the small GTPase Ran, which move cargo between the nucleus and cytoplasm by passing through the nuclear pore complexes.
Panse, Vikram Govind, Hurt, Ed
core +1 more source
Computational and Structural Biotechnology Journal, 2022 Nuclear translocation of large proteins is mediated through karyopherins, carrier proteins recognizing specific motifs of cargo proteins, known as nuclear localization signals (NLS). However, only few NLS signals have been reported until now.
Athanasios A. Panagiotopoulos +10 more
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A survey of the specificity and mechanism of 1,6 hexanediol-induced disruption of nuclear transport
Nucleus, 2023 Selective transport through the nuclear pore complex (NPC) depends on the dynamic binding of FG-repeat containing nucleoporins, the FG-nups, with each other and with Karyopherins (Kaps).
Elizabeth C. Riquelme Barrientos +4 more
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Structures of the Karyopherins Kap121p and Kap60p Bound to the Nuclear Pore-Targeting Domain of the SUMO Protease Ulp1p [PDF]
, 2017 The budding yeast small ubiquitin-like modifier (SUMO) protease Ulp1p catalyzes both the processing of newly synthesized SUMO to its mature form and the deconjugation of SUMO from target proteins, thereby regulating a wide range of cellular processes ...
Matsuura, Yoshiyuki +2 more
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The IMPORTance of the Nucleus during Flavivirus Replication
Viruses, 2017 Flaviviruses are a large group of arboviruses of significant medical concern worldwide. With outbreaks a common occurrence, the need for efficient viral control is required more than ever.
Adam J. Lopez-Denman, Jason M. Mackenzie
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The Journal of Clinical Investigation, 2023 The genetic basis of preimplantation embryo arrest is slowly being unraveled. Recent discoveries point to maternally expressed proteins required for cellular functions before the embryonic genome is activated. In this issue of the JCI, Wang, Miyamoto, et
Momal Sharif +2 more
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eLife, 2020 HIV-1 must replicate in cells that are equipped to defend themselves from infection through intracellular innate immune systems. HIV-1 evades innate immune sensing through encapsidated DNA synthesis and encodes accessory genes that antagonize specific ...
Hataf Khan +11 more
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Karyopherins in nuclear transport of homeodomain proteins during development [PDF]
, 2011 Homeodomain proteins are crucial transcription factors for cell differentiation, cell proliferation and organ development. Interestingly, their homeodomain signature structure is important for both their DNA-binding and their nucleocytoplasmic ...
Wenduo Ye +8 more
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Karyopherins regulate nuclear pore complex barrier and transport function [PDF]
, 2017 Nucleocytoplasmic transport is sustained by karyopherins (Kaps) and a Ran guanosine triphosphate (RanGTP) gradient that imports nuclear localization signal (NLS)–specific cargoes (NLS-cargoes) into the nucleus.
Lim, Roderick Y. H. +7 more
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