Results 21 to 30 of about 4,908 (204)

The Ebola Virus Interferon Antagonist VP24 Undergoes Active Nucleocytoplasmic Trafficking

Viruses, 2021
Viral interferon (IFN) antagonist proteins mediate evasion of IFN-mediated innate immunity and are often multifunctional, with distinct roles in viral replication.
Angela R. Harrison, Cassandra T. David, Stephen M. Rawlinson, Gregory W. Moseley   +3 more
doaj   +1 more source

Nucleocytoplasmic Trafficking Perturbation Induced by Picornaviruses

Viruses, 2021
Picornaviruses are positive-stranded RNA viruses. Even though replication and translation of their genome take place in the cytoplasm, these viruses evolved different strategies to disturb nucleocytoplasmic trafficking of host proteins and RNA. The major
Belén Lizcano-Perret, Thomas Michiels
doaj   +1 more source

Recognition motifs for importin 4 [(L)PPRS(G/P)P] and importin 5 [KP(K/Y)LV] binding, identified by bio-informatic simulation and experimental in vitro validation

Computational and Structural Biotechnology Journal, 2022
Nuclear translocation of large proteins is mediated through karyopherins, carrier proteins recognizing specific motifs of cargo proteins, known as nuclear localization signals (NLS). However, only few NLS signals have been reported until now.
Athanasios A. Panagiotopoulos, Konstantina Kalyvianaki, Paraskevi K. Tsodoulou, Maria N. Darivianaki, Dimitris Dellis, George Notas, Vangelis Daskalakis, Panayiotis A. Theodoropoulos, Christos Α. Panagiotidis, Elias Castanas, Marilena Kampa   +10 more
doaj   +1 more source

KPNB1 (karyopherin (importin) beta 1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013
Review on KPNB1 (karyopherin (importin) beta 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Maria Giubettini, Pauline van der Watt, Annalisa Verrico, Valeria de Turris, Virna Leaner, Patrizia Lavia   +5 more
openaire   +3 more sources

Exportins can inhibit major mitotic assembly events in vitro: membrane fusion, nuclear pore formation, and spindle assembly

Nucleus, 2020
Xenopus egg extracts are a powerful in vitro tool for studying complex biological processes, including nuclear reconstitution, nuclear membrane and pore assembly, and spindle assembly.
Matthew S. Nord, Cyril Bernis, Sarah Carmona, Dennis C. Garland, Anna Travesa, Douglass J. Forbes   +5 more
doaj   +1 more source

Quantitative Nucleocytoplasmic Transport Assays in Cellular Models of Neurodegeneration

Bio-Protocol, 2020
Nucleocytoplasmic transport deficits are suggested to play a role in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Given the importance and complexity of this process, understanding when these aberrations occur and which ...
Joni Vanneste, Thomas Vercruysse, Philip Van Damme, Ludo Van Den Bosch, Dirk Daelemans   +4 more
doaj   +1 more source

Loss of the importin Kpna2 causes infertility in male mice by disrupting the translocation of testis-specific transcription factors

iScience, 2023
Summary: Karyopherins mediate the movement between the nucleus and cytoplasm of specific proteins in diverse cellular processes. Through a loss-of-function approach, we here examine the role of Karyopherin Subunit Alpha 2 (Kpna2) in spermatogenesis ...
Paula Navarrete-López, María Maroto, Eva Pericuesta, Raúl Fernández-González, Marta Lombó, Priscila Ramos-Ibeas, Alfonso Gutiérrez-Adán   +6 more
doaj   +1 more source

Expression of Karyopherin Alpha 2 and Karyopherin Beta 1 Correlate with Poor Prognosis in Gastric Cancer

Oncology, 2022
<b><i>Introduction:</i></b> Karyopherin alpha 2 (KPNA2) and karyopherin beta 1 (KPNB1) constitute nuclear transport protein complexes involved in nuclear import and are significant in tumor progression. Although high KPNA2 expression was associated with poor prognosis in solid tumors, the relationship between KPNA2 and KPNB1 ...
Yoshihito Ohhara, Ichiro Kinoshita, Akira Suzuki, Makoto Imagawa, Jun Taguchi, Takuro Noguchi, Satoshi Takeuchi, Yasushi Shimizu, Hideyuki Seki, Junichi Suzuki, Hirotoshi Dosaka-Akita   +10 more
openaire   +2 more sources

A survey of the specificity and mechanism of 1,6 hexanediol-induced disruption of nuclear transport

Nucleus, 2023
Selective transport through the nuclear pore complex (NPC) depends on the dynamic binding of FG-repeat containing nucleoporins, the FG-nups, with each other and with Karyopherins (Kaps).
Elizabeth C. Riquelme Barrientos, Tegan A. Otto, Sara N. Mouton, Anton Steen, Liesbeth M. Veenhoff   +4 more
doaj   +1 more source

A karyopherin acts in localized protein synthesis [PDF]

Cell Cycle, 2010
Multiple mechanisms are in place to regulate adequate synthesis of proteins, ranging from ways to ensure sequence fidelity, polypeptide folding and protein modification, to control of amounts and subcellular localization of the molecules. Some of these mechanisms act at the level of mRNA export and mRNA targeting.
Veenhoff, Liesbeth M., Meinema, Anne C., Poolman, Bert   +2 more
openaire   +2 more sources