Results 41 to 50 of about 4,908 (204)

Pore timing:the evolutionary origins of the nucleus and nuclear pore complex [PDF]

, 2019
The name “eukaryote” is derived from Greek, meaning “true kernel”, and describes the domain of organisms whose cells have a nucleus. The nucleus is thus the defining feature of eukaryotes and distinguishes them from prokaryotes (Archaea and Bacteria ...
A Noble, A O'Reilly, A Ori, A Pittis, A Poole, A Spang, A von Appen, C Klinger, D Devos, D Devos, D Lin, E Arakel, E Szathmáry, F Alber, G Dey, G Holzer, H Asakawa, J Cronshaw, J Dacks, J Dacks, J DeGrasse, J Fischer, J Gomez-Cavazos, J Holden, J Kosinski, K Knockenhauer, K Leung, K Tamura, K Zaremba-Niedzwiedzka, M Beck, M Beck, M D'Angelo, M Eibauer, M Faini, M Field, M Field, M Field, M Iwamoto, M Paraan, M Raices, M Robinson, M Rout, M Rout, N Yutin, P Sampathkumar, R Hayama, R Teimer, S Dodonova, S Fath, S Kim, S Mosalaganti, S Obado, S Obado, T Jovanovic-Talisman, T Ritterhoff, T Stuwe, V Sakin, W Martin, W Martin, Y Bykov   +59 more
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Birth, Death, and Replacement of Karyopherins in Drosophila [PDF]

Molecular Biology and Evolution, 2011
Nucleocytoplasmic transport is a broadly conserved process across eukaryotes. Despite its essential function and conserved mechanism, components of the nuclear transport apparatus have been implicated in genetic conflicts in Drosophila, especially in the male germ line. The best understood case is represented by a truncated RanGAP gene duplication that
Nitin, Phadnis, Emily, Hsieh, Harmit S, Malik   +2 more
openaire   +2 more sources

Mechanisms of Nuclear Export in Cancer and Resistance to Chemotherapy [PDF]

, 2016
YesTumour suppressor proteins, such as p53, BRCA1, and ABC, play key roles in preventing the development of a malignant phenotype, but those that function as transcriptional regulators need to enter the nucleus in order to function.
Bethany Raynor, El-Habib Dakir, Matchett, Mohamed El-Tanani, Richard Morgan, Talarico, Vincent   +6 more
core   +2 more sources

Importins/Karyopherins Meet Nucleoporins [PDF]

Cell, 1996
I thank Gunter Blobel, Valerie Doye, Dirk Gorlich, Iain Mattaj, Ulf Nehrbass, and Uli Scheer for helpful comments on the manuscript.
openaire   +1 more source

In vivo analysis of protein crowding within the nuclear pore complex in interphase and mitosis

Scientific Reports, 2017
The central channel of the nuclear pore complex (NPC) is occupied by non-structured polypeptides with a high content of Phe-Gly (FG) motifs. This protein-rich environment functions as an entropic barrier that prevents the passage of molecules, as well as
Hide A. Konishi, Suguru Asai, Tomonobu M. Watanabe, Shige H. Yoshimura   +3 more
doaj   +1 more source

Diversification of importin-α isoforms in cellular trafficking and disease states. [PDF]

, 2015
The human genome encodes seven isoforms of importin α which are grouped into three subfamilies known as α1, α2 and α3. All isoforms share a fundamentally conserved architecture that consists of an N-terminal, autoinhibitory, importin-β-binding (IBB ...
Ahluwalia, Andrade, Ao, Aratani, Arjomand, Banninger, Bannister, Bao, Bednenko, Ben-Yaakov, Bian, Bian, Boivin, Chang, Chen, Chen, Chen, Cingolani, Conti, Conti, Cook, Cortes, Cuomo, Dahl, de Barros, Depping, Dissanayake, Dolinsky, Donaldson, Du, Fagerlund, Fagerlund, Fagerlund, Fahrenkrog, Fanara, Fischer, Fontes, Fontes, Forwood, Friedrich, Frieman, Gabriel, Ghosh, Giesecke, Gino Cingolani, Glinsky, Goldfarb, Gorlich, Gorlich, Gousias, Gousias, Grundt, Guillemain, Haenni, Han, Hanz, Harreman, Harreman, Hatayama, Hearps, Henikoff, Hogarth, Holt, Hosokawa, Hu, Huang, Huang, Hudjetz, Huenniger, Hugel, Ilmarinen, Isegawa, Jans, Jenkins, Jensen, Jin, Kamata, Kelley, Kim, Kitamura, Kobe, Kohler, Kohler, Kohler, Koksal, Koksal, Kosugi, Kumar, Lai, Lange, Larkin, Laurila, Lee, Levin, Li, Li, Li, Liang, Lin, Liu, Liu, Lott, Lott, Lufei, Ma, Maas, Macara, Mahalakshmi, Marchenko, Marfori, Marshall, Mason, Matsuura, Matsuura, McConville, Mehmood, Melen, Melzer, Meyer, Misheva, Miyamoto, Miyamoto, Miyamoto, Montgomery, Moriyama, Morris, Mortezavi, Nachury, Nadler, Najarro, Nakamura, Nardozzi, Nardozzi, Nishinaka, Nitahara-Kasahara, O'Neill, O'Neill, Okada, Paciorkowski, Page, Papadopoulos, Paterson, Perez-Villar, Perry, Pettersen, Poon, Pujol, Pumroy, Pumroy, Qu, Reid, Reid, Resa-Infante, Resa-Infante, Rivera, Roman, Rona, Rother, Roussos, Ruth A. Pumroy, Sakai, Seki, Sekimoto, Sekimoto, Shabman, Shaw, Shin, Shmidt, Simkus, Sims, Snow, Song, Spanopoulou, Stewart, Sun, Sun, Sun, Tachibana, Takeda, Takeda, Takeda, Talcott, Tarendeau, Tay, Taylor, Tejomurtula, Theiss, Thomas, Torgerson, Tseng, Tsuji, Umegaki, Ushijima, van der Watt, van der Watt, Wagstaff, Wang, Wang, Wang, Wang, Weis, Weis, Welch, Wente, Winnepenninckx, Xu, Yang, Yang, Yano, Yasuhara, Yasuhara, Ye, Yeung, Yeung, Yoshitake, Zachariae, Zhang, Zhen, Zheng, Zhong, Zhou, Zienkiewicz   +221 more
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Karyopherins play the field [PDF]

The Journal of Cell Biology, 2006
![][1] Import of proteins (green) into the nucleus is slower than expected, revealing that karyopherins are choosy about their cargo. Proteins that shuttle molecules into the nucleus face the same problem as customers of a dating service.
openaire   +1 more source

Modulation of Histone Deposition by the Karyopherin Kap114 [PDF]

Molecular and Cellular Biology, 2005
The nuclear import of histones is a prerequisite for the downstream deposition of histones to form chromatin. However, the coordinate regulation of these processes remains poorly understood. Here we demonstrate that Kap114p, the primary karyopherin/importin responsible for the nuclear import of histones H2A and H2B, modulates the deposition of histones
Nima, Mosammaparast, Brian C, Del Rosario, Lucy F, Pemberton   +2 more
openaire   +2 more sources

Karyopherin Alpha Proteins Regulate Oligodendrocyte Differentiation

PLOS ONE, 2017
Proper regulation of the coordinated transcriptional program that drives oligodendrocyte (OL) differentiation is essential for central nervous system myelin formation and repair. Nuclear import, mediated in part by a group of karyopherin alpha (Kpna) proteins, regulates transcription factor access to the genome.
Benjamin M. Laitman, John N. Mariani, Chi Zhang, Setsu Sawai, Gareth R. John   +4 more
openaire   +4 more sources

A Role for the Karyopherin Kap123p in Microtubule Stability [PDF]

Traffic, 2009
Several components of the nuclear transport machinery play a role in mitotic spindle assembly in higher eukaryotes. To further investigate the role of this family of proteins in microtubule function, we screened for mutations in Saccharomyces cerevisiae that confer sensitivity to microtubule‐destabilizing drugs.
Christopher, Ptak, Andrea M, Anderson, Robert J, Scott, David, Van de Vosse, Richard S, Rogers, Yaroslav, Sydorskyy, John D, Aitchison, Richard W, Wozniak   +7 more
openaire   +2 more sources