Nuclear Import and Export Signals of Human Cohesins SA1/STAG1 and SA2/STAG2 Expressed in Saccharomyces cerevisiae [PDF]
, 2012 Background: Human SA/STAG proteins, homologues of the yeast Irr1/Scc3 cohesin, are the least studied constituents of the sister chromatid cohesion complex crucial for proper chromosome segregation.
Jurek, Marta +27 more
core +1 more source
Karyopherin α 3 and Karyopherin α 4 Proteins Mediate the Nuclear Import of Methyl-CpG Binding Protein 2 [PDF]
Journal of Biological Chemistry, 2015 Methyl-CpG binding protein 2 (MeCP2) is a nuclear protein with important roles in regulating chromatin structure and gene expression, and mutations in MECP2 cause Rett syndrome (RTT). Within the MeCP2 protein sequence, the nuclear localization signal (NLS) is reported to reside between amino acids 255-271, and certain RTT-causing mutations overlap with
Steven Andrew, Baker +2 more
openaire +2 more sources
The adapter importin‐α provides flexible control of nuclear import at the expense of efficiency
Molecular Systems Biology, 2007 Although there exists a large family of nuclear transport receptors (Karyopherins), the majority of known import cargoes use an adapter protein, Importin‐α (Impα), which links the cargo to a karyopherin, Importin‐β (Impβ). The reason for the existence of
Greg Riddick, Ian G Macara
doaj +1 more source
Nuclear import of yeast Gcn4p requires karyopherins Srp1p and Kap95p
, 2004 The yeast transcription factor Gcn4p contains two stretches of amino acid residues, NLS1 and NLS2, which are independently able to relocate the cytoplasmic protein chorismate mutase into the nucleus. Only NLS2 is conserved among fungi.
Draht, Oliver W. +4 more
core +1 more source
Importins and Exportins Regulating Allergic Immune Responses
Mediators of Inflammation, 2014 Nucleocytoplasmic shuttling of macromolecules is a well-controlled process involving importins and exportins. These karyopherins recognize and bind to receptor-mediated intracellular signals through specific signal sequences that are present on cargo ...
Ankita Aggarwal, Devendra K. Agrawal
doaj +1 more source
Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus. [PDF]
PLoS Genetics, 2015 Regulated nuclear entry of clock proteins is a conserved feature of eukaryotic circadian clocks and serves to separate the phase of mRNA activation from mRNA repression in the molecular feedback loop.
A Reum Jang +4 more
doaj +1 more source
Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs +7 more
wiley +1 more source
Evolutionary and Transcriptional Analysis of Karyopherin β Superfamily Proteins [PDF]
Molecular & Cellular Proteomics, 2008 In eukaryotes, karyopherin beta superfamily proteins mediate nucleocytoplasmic transport of macromolecules. We investigated the evolutionary and transcriptional patterns of these proteins using bioinformatics approaches. No obvious homologs were found in prokaryotes, but an extensive set of beta-karyopherin proteins was found in yeast.
Quan, Y. +4 more
openaire +3 more sources
Dissecting in vivo steady-state dynamics of karyopherin-dependent nuclear transport [PDF]
, 2016 Karyopherin-dependent molecular transport through the nuclear pore complex is maintained by constant recycling pathways of karyopherins coupled with the Ran-dependent cargo catch-and-release mechanism.
Kumeta, Masahiro +4 more
core +1 more source
Survival, bacterial clearance and thrombocytopenia are improved in polymicrobial sepsis by targeting nuclear transport shuttles. [PDF]
PLoS ONE, 2017 The rising tide of sepsis, a leading cause of death in the US and globally, is not adequately controlled by current antimicrobial therapies and supportive measures, thereby requiring new adjunctive treatments.
Ruth Ann Veach +6 more
doaj +1 more source