Results 61 to 70 of about 3,830 (141)
Cell Proliferation, Volume 59, Issue 8, August 2026.Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao +7 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are heterobifunctional molecules that hijack the ubiquitin‐proteasome system to drive catalytic, sub‐stoichiometric degradation of disease‐associated proteins, offering a mechanistic advantage over occupancy‐driven inhibitors and access to ‘undruggable’ targets.
Sruti Bagchi Ghosh +9 more
wiley +1 more source
Evidence for an evolutionary relationship between the large adaptor nucleoporin Nup192 and karyopherins [PDF]
, 2014 Nucleocytoplasmic transport is facilitated by nuclear pore complexes (NPCs), which are massive proteinaceous transport channels embedded in the nuclear envelope.
Lin, Daniel H. +4 more
core
Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1
, 2011 In human cells, the mRNA export factor NXF1 resides in the nucleoplasm and at nuclear pore complexes. Karyopherin β2 or transportin recognizes a proline–tyrosine nuclear localization signal (PY-NLS) in the N-terminal tail of NXF1 and imports it into the
Neal Satterly +3 more
core +1 more source
Frontiers in Oncology, 2016 Aurora A has been extensively characterized as a centrosomal kinase with essential functions during cell division including centrosome maturation and separation and spindle assembly. However, Aurora A localization is not restricted to the centrosomes and
Isabelle eVernos +6 more
doaj +1 more source
TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain
Advanced Science, Volume 13, Issue 40, 17 July 2026.TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando +2 more
wiley +1 more source
Investigating Ebola virus pathogenicity using molecular dynamics
BMC Genomics, 2017 Background Ebolaviruses have been known to cause deadly disease in humans for 40 years and have recently been demonstrated in West Africa to be able to cause large outbreaks.
Morena Pappalardo +5 more
doaj +1 more source
Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.NSCLC contains an MHC‐II‐associated antigen‐presenting CAF‐like (apCAF‐like) state regulated by the NRF2‐KPNB1 axis. NRF2/KPNB1 signaling suppresses CIITA‐dependent antigen presentation and T‐cell activation, whereas inhibition of this pathway enhances antitumor immunity and improves responsiveness to anti‐PD‐1 therapy.
Fei Zheng +5 more
wiley +1 more source
Bcp1 is the nuclear chaperone of Rpl23 in Saccharomyces cerevisiae [PDF]
, 2017 Eukaryotic ribosomes are composed of rRNAs and ribosomal proteins. Ribosomal proteins are translated in the cytoplasm and imported into the nucleus for assembly with the rRNAs.
Ting, Ya Han +6 more
core +2 more sources
Comprehensive Physiology, Volume 16, Issue 3, June 2026.This review summarizes how extracellular vesicles from diverse pulmonary and extrapulmonary sources contribute to endothelial dysfunction in ARDS and evaluates emerging endothelial‐targeted therapies for their potential to mitigate EV‐mediated pathogenic mechanisms.
Mohammed Yaman Al Matni +3 more
wiley +1 more source