Results 81 to 90 of about 4,908 (204)
The Kap60-Kap95 Karyopherin Complex Directly Regulates Phosphatidylcholine Synthesis [PDF]
Journal of Biological Chemistry, 2009 Phosphatidylcholine is the major phospholipid in eukaryotic cells. There are two main pathways for the synthesis of phosphatidylcholine: the CDP-choline pathway present in all eukaryotes and the phosphatidylethanolamine methylation pathway present in mammalian hepatocytes and some single celled eukaryotes, including the yeast Saccharomyces cerevisiae ...
Melissa A, MacKinnon +5 more
openaire +2 more sources
Frontiers in Molecular Neuroscience, 2018 The building of the brain is a multistep process that requires the coordinate expression of thousands of genes and an intense nucleocytoplasmic transport of RNA and proteins.
Gerry Nganou +17 more
doaj +1 more source
Molecular basis for protection of ribosomal protein L4 from cellular degradation [PDF]
, 2017 Eukaryotic ribosome biogenesis requires the nuclear import of ∼80 nascent ribosomal proteins and the elimination of excess amounts by the cellular degradation machinery.
Hoelz, André, Huber, Ferdinand M.
core +1 more source
Dualistic Roles of High Mobility Group Box 1 in Cancer and Inflammation
Cancer Medicine, Volume 14, Issue 23, December 2025.ABSTRACT Background The High Mobility Group Box 1 (HMGB1) protein, a member of the HMG family, plays a crucial role in both cancer progression and inflammatory responses. HMGB1 can act as a damage‐associated molecular pattern (DAMP) to activate immune responses and modulate inflammation.
Wen Zeng +6 more
wiley +1 more source
Towards reconciling structure and function in the nuclear pore complex [PDF]
, 2018 The spatial separation between the cytoplasm and the cell nucleus necessitates the continuous exchange of macromolecular cargo across the double-membraned nuclear envelope.
Aebi, Ueli +2 more
core
A Proteomic Survey of Host and Virus Reveals Differential Dynamics [PDF]
, 2014 We studied the dynamics of the proteome of influenza virus A/PR/8/34 (H1N1) infected Madin-Darby canine kidney cells up to 12 hours post infection by mass spectrometry based quantitative proteomics using the approach of stable isotope labeling by amino ...
Flöttmann, Max +7 more
core +1 more source
Small Science, Volume 5, Issue 11, November 2025.Cancer and neurodegeneration share interconnected nanosized molecular pathways. Novel nanobiomedicine approaches promise targeted biomarkers and therapies. Atomic force microscopy (AFM) is invaluable to characterize nanosized biomolecular processes beyond imaging.
Carlos Marcuello +5 more
wiley +1 more source
Determining Factors Influencing Nuclear Envelope and Nuclear Pore Complex Structure. [PDF]
, 2013 The cell’s nuclear envelope (NE) has pores that are stabilized by nuclear pore complexes (NPC), large proteinaceous structures whose function is to mediate transport between the nucleus and cytoplasm.
Gouni, Sushanth
core +1 more source
A novel DAG-dependent mechanism links PKCa and Cyclin B1 regulating cell cycle progression [PDF]
, 2014 Through the years, different studies showed the involvement of Protein Kinase C (PKC) in cell cycle control, in particular during G1/S transition. Little is known about their role at G2/M checkpoint.
Assoian +47 more
core +2 more sources
Advanced Science, Volume 12, Issue 38, October 13, 2025.This study demonstrates that SenExo‐cCCT2 enables targeted delivery of cCCT2 to pancreatic cancer cells, where it disrupts IPO13‐mediated nuclear translocation of UBC9, impairing SUMOylation‐dependent DNA damage repair and inducing senescence. Senescent tumor cells secrete CXCL10 to recruit CD8⁺ T‐cells while upregulating PD‐L1.
Shuncang Zhu +18 more
wiley +1 more source