Results 81 to 90 of about 3,830 (141)
Subcellular pools of karyopherins KapA and KapB.
, 2013 A) Fractionation procedure for strains expressing KapB::GFP or KapA::mRFP (based on reference [38]). The diagram shows the predicted content of each fraction generated. B) Western-blot experiments showing the karyopherin-α or -β1 content of each cellular
María Villarino (500708) +4 more
core +1 more source
The Regulation of Cellular Localization of Both Active and Inactive ERK1/2 [PDF]
, 2009 A key question concerning the regulation and activity attributed to the extracellular signal regulated kinase1/2 (ERK1/2) cascade is how the cellular response to different ligands, cellular environment, and other cellular signals is generated.
Goad, Daryl Len
core +2 more sources
Nuclear import of HIV-1 -- optimizing siRNA techniques
, 2004 In this project, the preliminary work for a study of nuclear import of HIV-1 in macrophages was conducted. RNA inhibition was used to prevent expression of karyopherins a1, a2, b2, and RCC1.
Norgard, Elizabeth Anne
core +3 more sources
Normal male fertility in a mouse model of KPNA2 deficiency.
PLoS ONEThe nuclear transport of proteins is mediated by karyopherins and has been implicated to be crucial for germ cell and embryonic development. Deletion of distinct members of the karyopherin alpha family has been shown to cause male and female infertility ...
Franziska Rother +3 more
doaj +1 more source
Transport of LINE1 retrotransposons into nucleus by karyopherins
Retrotranspozoni LINE1 (ang. long interspersed nuclear element) so avtonomni mobilni DNA elementi, ki predstavljajo 17 % človeškega genoma in so edina aktivna različica transpozicijskih elementov pri človeku.
Nograšek, Tim
core
Karyopherin α2 is a maternal effect gene required for early embryonic development and female fertility in mice [PDF]
The nuclear transport of proteins plays an important role in mediating the transition from egg to embryo and distinct karyopherins have been implicated in this process. Here, we studied the impact of KPNA2 deficiency on preimplantation embryo development
Depping, R. +6 more
core +1 more source
Identifying a novel region in the Tembusu virus NS5 protein antagonizing type I interferon signaling
Journal of VirologyNumerous species in the genus Flavivirus have been identified to pose serious threats to public health. Most of them have developed evasion strategies to counteract antiviral activity triggered by type I interferon (IFN-I), making prevention and control ...
Ji Zhang +13 more
doaj +1 more source
Characterization of the mechanism of action of Transportin in mitotic spindle assembly [PDF]
, 2011 In eukaryotic cells, proteins known as karyopherins function during interphase as nuclear import and export receptors. Importin [beta] and Transportin, two such karyopherins, act to carry proteins with different recognition sites into the interphase ...
Swift-Taylor, Mary Elizabeth
core
Nuclear pore complexes (NPCs) regulate macromolecular transport into and out of the cell nucleus. However, the dynamic organization of the NPC transport barrier remains unresolved.
Rout, Michael P. +20 more
core +1 more source
Evolutionary and transcriptional analysis of karyopherin beta superfamily proteins
, 2008 In eukaryotes, karyopherin beta superfamily proteins mediate nucleocytoplasmic transport of macromolecules. We investigated the evolutionary and transcriptional patterns of these proteins using bioinformatics approaches. No obvious homologs were found in
Ji, Z. L. +5 more
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