Results 91 to 100 of about 3,763 (189)

The Ran pathway in Drosophila melanogaster mitosis

Frontiers in Cell and Developmental Biology, 2015
Over the last two decades, the small GTPase Ran has emerged as a central regulator of both mitosis and meiosis, particularly in the generation, maintenance and regulation of the microtubule (MT)-based bipolar spindle.
James G Wakefield, Jack Wei-Chu Chen, Amy eBarker, Amy eBarker   +3 more
doaj   +1 more source

Reprogramming SREBP1‐dependent lipogenesis and inflammation in high‐risk breast with licochalcone A: A novel path to cancer prevention

International Journal of Cancer, Volume 158, Issue 7, Page 1927-1940, 1 April 2026.
What's new? Endocrine drugs repurposed from treatment protocols are the primary medications available for breast cancer (BC) prevention in at‐risk women. Adverse effects, however, significantly minimize uptake and prevention impact. Here, the authors investigated licochalcone A (LicA), a non‐endocrine anti‐inflammatory agent with reported hematologic ...
Atieh Hajirahimkhan, Elizabeth T. Bartom, Carolina H. Chung, Xingyu Guo, Kyli Berkley, Seyyedmohsen Hosseinibarkooie, Zahra Assadi, Shao Huan Samuel Weng, Raymond Moellering, Oukseub Lee, Ruohui Chen, Wonhwa Cho, Sriram Chandrasekaran, Susan E. Clare, Seema A. Khan   +14 more
wiley   +1 more source

Non-centrosomal TPX2-dependent regulation of the Aurora A kinase: functional implications for healthy and pathological cell division

Frontiers in Oncology, 2016
Aurora A has been extensively characterized as a centrosomal kinase with essential functions during cell division including centrosome maturation and separation and spindle assembly. However, Aurora A localization is not restricted to the centrosomes and
Isabelle eVernos, Isabelle eVernos, Isabelle eVernos, Isabelle eVernos, Georgina eGarrido, Georgina eGarrido, Georgina eGarrido   +6 more
doaj   +1 more source

Histone Nuclear Import and Beyond: Multifunctional Roles of Importins

BioEssays, Volume 48, Issue 2, February 2026.
Efficient nuclear import of histones requires coordinated action between histone chaperones and nuclear import receptors. Importin‐4, Importin‐9, and Importin‐β/7 not only transport specific histone complexes but also act as chaperones, stabilizing histones and ensuring their protected delivery for nucleosome assembly, highlighting importins as central
Natalia Bernardes, Yuh Min Chook
wiley   +1 more source

A 3D Physical Model of Karyopherin‐β2

The FASEB Journal, 2012
Karyopherin beta 2 (Kapβ2) is an importin that transports various cargo proteins into the nucleus through interactions with nucleoporins, which are proteins of the nuclear pore complex (NPC). One might overlook the significance of this protein but it actually plays a crucial role in the human body.
Mary Acheampong, Rosieva Ashong-Katia, Kavita Bhikhi, Daviana Dueno, Bobby Glover, Lachoy Harris, Alafia Henry, Randol Mata, Hillary Ramirez, Marisa VanBrakle, Allison Granberry, Natalia E. Ketaren, Michael P. Rout   +12 more
openaire   +1 more source

Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes. [PDF]

Proceedings of the National Academy of Sciences, 1995
Previously, we had purified a cytosolic protein complex, termed karyopherin, that functions in docking import substrate at the nuclear envelope in digitonin-permeabilized cells and also had molecularly cloned and sequenced its 97-kDa beta subunit. We now report that the karyopherin alpha subunit is the previously identified protein NPI-1/SRP-1 of ...
J, Moroianu, G, Blobel, A, Radu
openaire   +2 more sources

Evidence for an evolutionary relationship between the large adaptor nucleoporin Nup192 and karyopherins [PDF]

, 2014
Nucleocytoplasmic transport is facilitated by nuclear pore complexes (NPCs), which are massive proteinaceous transport channels embedded in the nuclear envelope.
Lin, Daniel H., Hoelz, André, Stuwe, Tobias, Collins, Leslie N., Hurt, Ed   +4 more
core  

Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1

, 2011
In human cells, the mRNA export factor NXF1 resides in the nucleoplasm and at nuclear pore complexes. Karyopherin β2 or transportin recognizes a proline–tyrosine nuclear localization signal (PY-NLS) in the N-terminal tail of NXF1 and imports it into the
Neal Satterly, Yuh Min Chook, Beatriz M. A. Fontoura, Zi Chao Zhang   +3 more
core   +1 more source

Positive stranded RNA viruses: Dissecting the capsid of Hepatitis E and Chikungunya viruses [PDF]

, 2010
Capsid protein of two positive stranded RNA viruses, Hepatitis E virus (HEV) and Chikungunya virus (ChikV), were investigated. HEV was detected in swine serum collected in Germany.
Thomas, Saijo (gnd: 143547151)
core   +1 more source

TMEM106C, BSG, COPE, CDCA8, KPNA2, LIG1, UQCRH, and CCT5: Predictive of Survival and Immunotherapy Resistance in Hepatocellular Carcinoma

Human Mutation, Volume 2026, Issue 1, 2026.
Introduction Hepatocellular carcinoma (HCC) remains a leading cause of cancer‐related mortality worldwide, with cellular senescence playing a context‐dependent role in tumor progression and the immunosuppressive microenvironment. This study is aimed at identifying senescence‐related gene signatures through integrated single‐cell and transcriptomic ...
Kai Yu, Minqi Chen, Wanchao Hou, Jinhua Lu, Qianhan Liu, Wanrong Zeng, Zhengcai Du, Xiaotao Hou, Erwei Hao, Jiagang Deng, Peipei Gong   +10 more
wiley   +1 more source