Results 91 to 100 of about 4,908 (204)
Virology, 2000 We searched for cellular proteins that interact with Epstein-Barr (EBV) virus nuclear antigen-1, which is a latent EBV origin-binding protein detected in all EBV latently infected cells and essential for maintenance of the latent EBV genome, by a yeast two-hybrid screening of a B lymphocyte cDNA library in this study.
Ito, Sayuri +6 more
openaire +2 more sources
The Nuclear Pore Complex as a Flexible and Dynamic Gate [PDF]
, 2018 Nuclear pore complexes (NPCs) perforate the nuclear envelope and serve as the primary transport gates for molecular exchange between nucleus and cytoplasm.
Knockenhauer, Kevin Edward +1 more
core +1 more source
Clinical and Translational Science, Volume 18, Issue 10, October 2025.ABSTRACT Triple‐negative breast cancer (TNBC) is a particularly aggressive subtype of breast cancer with limited targeted therapeutic options. Exosomes, small membrane vesicles secreted by cells, play a crucial role in intercellular communication and material exchange. However, the role of exosome‐related genes (ERGs) in TNBC remains unclear.
Yuan Zhang +5 more
wiley +1 more source
PLoS ONE, 2011 PEDF (Pigment epithelium-derived factor) is a non-inhibitory member of the serpin gene family (serpinF1) that displays neurotrophic and anti-angiogenic properties.
Sergio Anguissola +5 more
doaj +1 more source
Advanced Science, Volume 12, Issue 36, September 25, 2025.This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz +14 more
wiley +1 more source
Karyopherin β2B participates in mRNA export from the nucleus [PDF]
Proceedings of the National Academy of Sciences, 2002 Transport of macromolecules between the cell nucleus and cytoplasm occurs through the nuclear pores and is mediated by soluble carriers known as karyopherins (Kaps), transportins, importins, or exportins. We report that Kap β2B (transportin-2) forms complexes with the mRNA export factor TAP in the presence of RanGTP, as shown by ...
Monee K, Shamsher +2 more
openaire +2 more sources
The Ran pathway in Drosophila melanogaster mitosis
Frontiers in Cell and Developmental Biology, 2015 Over the last two decades, the small GTPase Ran has emerged as a central regulator of both mitosis and meiosis, particularly in the generation, maintenance and regulation of the microtubule (MT)-based bipolar spindle.
James G Wakefield +3 more
doaj +1 more source
From membrane to nucleus: New roles and functions of SUMOylated IGF-1R and EGFR [PDF]
, 2015 Cell surface receptor tyrosine kinases (RTKs) role in cell signaling have been studied for decades and their role in cancer progression are undisputable.
Packham, Sylvia
core +1 more source
Advanced Science, Volume 12, Issue 35, September 18, 2025.βFaar selectively targets and inhibits the GTPase activity of the RAB18 protein, thereby reducing LD volume. Conversely, βFaar promotes nuclear translocation of the transcription factor IRF4 in inguinal white adipose tissue (iWAT), facilitating the browning of white adipose tissue and attenuating body fat accumulation.
Yue Yang +13 more
wiley +1 more source
Frontiers in Oncology, 2016 Aurora A has been extensively characterized as a centrosomal kinase with essential functions during cell division including centrosome maturation and separation and spindle assembly. However, Aurora A localization is not restricted to the centrosomes and
Isabelle eVernos +6 more
doaj +1 more source