Results 71 to 80 of about 3,830 (141)

Regulation of Immune Checkpoints: From Molecular Mechanisms to Clinical Therapies

MedComm, Volume 7, Issue 6, June 2026.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by unleashing antitumor immunity. This review comprehensively examines the molecular mechanisms underlying key immune checkpoints—including PD‐1/PD‐L1, CTLA‐4, and TIM‐3—and their clinical applications.
Qintao Ge, Liu Yu, Jiahe Lu, Aihetaimujiang Anwaier, Xiyue Xiao, Yonghao Chen, Dingwei Ye, Hailiang Zhang, Wenhao Xu, Wenbin Dai   +9 more
wiley   +1 more source

Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants

Advanced Science, Volume 13, Issue 27, 13 May 2026.
The diversity of plant condensates reflects constraints of sessile organisms to coordinate postembryonic development with environmental adaptation. This review examines how plants employ condensates to integrate temperature, light, redox, and nutrient signals.
Panagiotis N. Moschou, Dorothee Staiger
wiley   +1 more source

Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein Tpr

BMC Cell Biology, 2009
Background Tpr is a large protein with an extended coiled-coil domain that is localized within the nuclear basket of the nuclear pore complex. Previous studies 1 involving antibody microinjection into mammalian cells suggested a role for Tpr in nuclear ...
Frosst Phyllis D, Ben-Efraim Iris, Gerace Larry   +2 more
doaj   +1 more source

Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A

The EMBO Journal
Sphingosine and constrained analogs like FTY720 and SH-BC-893 restrain tumor growth through incompletely defined mechanisms that include protein phosphatase 2A (PP2A) activation.
Vaishali Jayashankar, Peter Kubiniok, Alison N McCracken, Rebeca G Gentry, Kazumi H Eckenstein, Lorenzo Sernissi, Vito Vece, Jean-Baptiste Garsi, Sarah Y Valles, Sunhee Jung, Natalie C Hoffman, Arielle S Perrochon, Elizabeth M Selwan, Brendan T Finicle, Mary Pitman, DaWei Lin, Éric Bonneil, Ruijuan Xu, Cungui Mao, Peter Kaiser, David A Fruman, David Mobley, Cholsoon Jang, Stephen Hanessian, Pierre Thibault, Aimee L Edinger   +25 more
doaj   +1 more source

Yeast karyopherin Kap95 is required for cell cycle progression at Start

BMC Cell Biology, 2010
Background The control of the subcellular localization of cell cycle regulators has emerged as a crucial mechanism in cell division regulation. The active transport of proteins between the nucleus and the cytoplasm is mediated by the transport receptors ...
Igual Juan, Taberner Francisco
doaj   +1 more source

Positive stranded RNA viruses: Dissecting the capsid of Hepatitis E and Chikungunya viruses [PDF]

, 2010
Capsid protein of two positive stranded RNA viruses, Hepatitis E virus (HEV) and Chikungunya virus (ChikV), were investigated. HEV was detected in swine serum collected in Germany.
Thomas, Saijo (gnd: 143547151)
core   +1 more source

Multiple telophase arrest bypassed (tab) mutants alleviate the essential requirement for Cdc15 in exit from mitosis in S. cerevisiae

BMC Genetics, 2002
Background The Mitotic Exit Network (MEN) proteins – including the protein kinase Cdc15 and the protein phosphatase Cdc14 – are essential for exit from mitosis in Saccharomyces cerevisiae.
Deshaies Raymond J, Shou Wenying
doaj   +1 more source

Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer

Cell Communication and Signaling, 2019
Background Members of the karyopherin superfamily serve as nuclear transport receptors/adaptor proteins and provide exchange of macromolecules between the nucleo- and cytoplasm.
Elisabeth Drucker, Kerstin Holzer, Stefan Pusch, Juliane Winkler, Diego F. Calvisi, Eva Eiteneuer, Esther Herpel, Benjamin Goeppert, Stephanie Roessler, Alessandro Ori, Peter Schirmacher, Kai Breuhahn, Stephan Singer   +12 more
doaj   +1 more source

Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution

Biology Direct, 2010
Background The transition from prokaryotes to eukaryotes was the most radical change in cell organisation since life began, with the largest ever burst of gene duplication and novelty.
Cavalier-Smith Thomas
doaj   +1 more source

Analysis of Regulation of Major Mitotic Assembly Events In Vitro by Nuclear Import and Export Receptors [PDF]

, 2018
This dissertation is an analysis of regulation of major mitotic assembly events by nuclear transport receptors, or karyopherins. Karyopherins, composed of both importins and exportins, are a large family of proteins that transport specific proteins and ...
Nord, Matthew
core   +1 more source