Results 71 to 80 of about 4,908 (204)

Comparative interactomics provides evidence for functional specialization of the nuclear pore complex [PDF]

, 2017
The core architecture of the eukaryotic cell was established well over one billion years ago, and is largely retained in all extant lineages. However, eukaryotic cells also possess lineage-specific features, frequently keyed to specific functional ...
Field, Mark C., Obado, Samson O., Rout, Michael P.   +2 more
core   +2 more sources

Reprogramming SREBP1‐dependent lipogenesis and inflammation in high‐risk breast with licochalcone A: A novel path to cancer prevention

International Journal of Cancer, Volume 158, Issue 7, Page 1927-1940, 1 April 2026.
What's new? Endocrine drugs repurposed from treatment protocols are the primary medications available for breast cancer (BC) prevention in at‐risk women. Adverse effects, however, significantly minimize uptake and prevention impact. Here, the authors investigated licochalcone A (LicA), a non‐endocrine anti‐inflammatory agent with reported hematologic ...
Atieh Hajirahimkhan, Elizabeth T. Bartom, Carolina H. Chung, Xingyu Guo, Kyli Berkley, Seyyedmohsen Hosseinibarkooie, Zahra Assadi, Shao Huan Samuel Weng, Raymond Moellering, Oukseub Lee, Ruohui Chen, Wonhwa Cho, Sriram Chandrasekaran, Susan E. Clare, Seema A. Khan   +14 more
wiley   +1 more source

Histone Nuclear Import and Beyond: Multifunctional Roles of Importins

BioEssays, Volume 48, Issue 2, February 2026.
Efficient nuclear import of histones requires coordinated action between histone chaperones and nuclear import receptors. Importin‐4, Importin‐9, and Importin‐β/7 not only transport specific histone complexes but also act as chaperones, stabilizing histones and ensuring their protected delivery for nucleosome assembly, highlighting importins as central
Natalia Bernardes, Yuh Min Chook
wiley   +1 more source

Nutritional status modulates box C/D snoRNP biogenesis by regulated subcellular relocalization of the R2TP complex [PDF]

, 2014
BACKGROUND: Box C/D snoRNPs, which are typically composed of box C/D snoRNA and the four core protein components Nop1, Nop56, Nop58, and Snu13, play an essential role in the modification and processing of pre-ribosomal RNA.
Liang Zhao, Taras Makhnevych, Walid A Houry, Weiwen Tang, Yoshito Kakihara   +4 more
core   +1 more source

TMEM106C, BSG, COPE, CDCA8, KPNA2, LIG1, UQCRH, and CCT5: Predictive of Survival and Immunotherapy Resistance in Hepatocellular Carcinoma

Human Mutation, Volume 2026, Issue 1, 2026.
Introduction Hepatocellular carcinoma (HCC) remains a leading cause of cancer‐related mortality worldwide, with cellular senescence playing a context‐dependent role in tumor progression and the immunosuppressive microenvironment. This study is aimed at identifying senescence‐related gene signatures through integrated single‐cell and transcriptomic ...
Kai Yu, Minqi Chen, Wanchao Hou, Jinhua Lu, Qianhan Liu, Wanrong Zeng, Zhengcai Du, Xiaotao Hou, Erwei Hao, Jiagang Deng, Peipei Gong   +10 more
wiley   +1 more source

Inhibition of Karyopherin beta 1 suppresses prostate cancer growth [PDF]

Oncogene, 2019
Prostate cancer (PCa) initiation and progression requires activation of numerous oncogenic signaling pathways. Nuclear-cytoplasmic transport of oncogenic factors is mediated by Karyopherin proteins during cell transformation. However, the role of nuclear transporter proteins in PCa progression has not been well defined.
Yang, Jian, Gsuo, Yuqi, Lu, Cuijie, Zhang, Ruohan, Wang, Yaoyu, Luo, Liang, Zhang, Yanli, Chu, Catherine H, Wang, Katherine J, Obbad, Sabrine, Yan, Wenbo, Li, Xin   +11 more
openaire   +2 more sources

Mechanism and Regulation of Nucleocytoplasmic Trafficking of Smad

Cell & Bioscience, 2011
Smad proteins are the intracellular mediators of transforming growth factor β (TGF-β) signaling. Smads function as transcription factors and their activities require carboxyl-terminal phosphorylation by TGF-β receptor kinases which are embedded in the ...
Chen Xiaochu, Xu Lan
doaj   +1 more source

Elucidation of the ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function [PDF]

, 2014
Viral pathogenesis in the infected cell is a balance between antiviral responses and subversion of host-cell processes. Many viral proteins specifically interact with host-cell proteins to promote virus biology.
Altamirano A. A., Boulon S., David Matthews, Dodson A. W., Ebihara H., Emmott E., Feldmann F., Huggins J., Isabel García-Dorival, Iwasa A., John N. Barr, Jonathan Wastling, Jourdan S. S., Julian A. Hiscox, Karuppannan A. K., Lee M. S., Marsh G. A., Mateo M., Mateo M., Mateo M., Mateo M., Miles Carroll, Nanbo A., Olivier Touzelet, Pichlmair A., Ramanan P., Randall R. E., Reid S. P., Reid S. P., Roger Hewson, Smith D. R., Spurgers K. B., Stuart Armstrong, Stuart Dowall, Trinkle-Mulcahy L., Trombley A. R., Volchkov V. E., Watanabe S., Weingartl H. M., Weining Wu, Wu W., Zhang A. P.   +41 more
core   +1 more source

Health Benefits and Therapeutic Potential of Quercetin

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Quercetin, a polyphenolic compound prevalent in many fruits, vegetables, and other dietary sources, has attracted considerable interest due to its extensive health benefits. This review examines its diverse biological properties, particularly its antioxidant and anti‐inflammatory effects. The study integrates recent scientific findings to elucidate the
Mahendra Aryal, Kim Wei Chan
wiley   +1 more source

Nuclear import by karyopherin-βs: Recognition and inhibition

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011
Proteins in the karyopherin-β family mediate the majority of macromolecular transport between the nucleus and the cytoplasm. Eleven of the 19 known human karyopherin-βs and 10 of the 14S. cerevisiae karyopherin-βs mediate nuclear import through recognition of nuclear localization signals or NLSs in their cargos.
Chook, Yuh Min, Süel, Katherine E.
openaire   +2 more sources