Results 71 to 80 of about 3,763 (189)

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Diacerein Disrupts Testicular Homeostasis: The Essential Role of Basal Cytokines in Maintaining Sertoli Cell Integrity and the Immune Microenvironment

Andrology, EarlyView.
ABSTRACT Background Pro‐inflammatory cytokines, TNF and IL‐1B, are essential for testicular homeostasis. Diacerein, an anti‐inflammatory drug, inhibits these cytokines, impairing M2 macrophages and Leydig cells (LCs). However, its impact on Sertoli cells (SCs) and M1 (CD68) macrophages remains unknown.
Elide Loise Freitas de Jesus, André Acácio Souza da Silva, Olumide Stephen Akinsomisoye, Erick J. R. Silva, Paulo Sérgio Cerri, Salmo Azambuja de Oliveira, Estela Sasso‐Cerri   +6 more
wiley   +1 more source

Recognition of nuclear targeting signals by Karyopherin-β proteins [PDF]

Current Opinion in Structural Biology, 2010
The Karyopherin-β family of nuclear transport factors mediates the majority of nucleocytoplasmic transport. Although each of the 19 Karyopherin-βs transports unique sets of cargos, only three classes of nuclear localization and export signals, or NLSs and NESs, have been characterized. The short basic classical-NLS was first discovered in the 1980s and
Darui, Xu, Alicia, Farmer, Yuh Min, Chook   +2 more
openaire   +2 more sources

Mechanism and Regulation of Nucleocytoplasmic Trafficking of Smad

Cell & Bioscience, 2011
Smad proteins are the intracellular mediators of transforming growth factor β (TGF-β) signaling. Smads function as transcription factors and their activities require carboxyl-terminal phosphorylation by TGF-β receptor kinases which are embedded in the ...
Chen Xiaochu, Xu Lan
doaj   +1 more source

Multi‐omics analysis identifies a major histocompatibility complex class II‐associated antigen‐presenting cancer‐associated fibroblast‐like state linked to the nuclear factor erythroid 2‐related factor 2‐karyopherin subunit beta 1 axis in nonsmall cell lung cancer

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
NSCLC contains an MHC‐II‐associated antigen‐presenting CAF‐like (apCAF‐like) state regulated by the NRF2‐KPNB1 axis. NRF2/KPNB1 signaling suppresses CIITA‐dependent antigen presentation and T‐cell activation, whereas inhibition of this pathway enhances antitumor immunity and improves responsiveness to anti‐PD‐1 therapy.
Fei Zheng, Ruoying Deng, Ran Hou, Lei Hong, Yanzhi Cui, Yibing Liu   +5 more
wiley   +1 more source

Karyopherin Alpha Proteins Regulate Oligodendrocyte Differentiation

PLOS ONE, 2017
Proper regulation of the coordinated transcriptional program that drives oligodendrocyte (OL) differentiation is essential for central nervous system myelin formation and repair. Nuclear import, mediated in part by a group of karyopherin alpha (Kpna) proteins, regulates transcription factor access to the genome.
Benjamin M. Laitman, John N. Mariani, Chi Zhang, Setsu Sawai, Gareth R. John   +4 more
openaire   +4 more sources

Cloning and characterization of the tomato karyopherin α1 gene promoter [PDF]

Development, Growth & Differentiation, 2004
The karyopherin α1 (LeKAPα 1) gene of tomato (Lycopersicon esculentum) encodes a receptor involved in nuclear import. To analyze the expression pattern of this gene, a genomic clone containing its upstream region was isolated and sequenced. To study the promoter functionality, a 2170 bp fragment (LM1), was fused to glucuronidase (GUS) and introduced ...
Liat, Mizrachy, David, Dabush, Yael, Levy, Roni, Aloni, Arie, Altman, Yedidya, Gafni   +5 more
openaire   +2 more sources

Importin-8 Modulates Division of Apical Progenitors, Dendritogenesis and Tangential Migration During Development of Mouse Cortex

Frontiers in Molecular Neuroscience, 2018
The building of the brain is a multistep process that requires the coordinate expression of thousands of genes and an intense nucleocytoplasmic transport of RNA and proteins.
Gerry Nganou, Gerry Nganou, Carla G. Silva, Ivan Gladwyn-Ng, Dominique Engel, Bernard Coumans, Bernard Coumans, Antonio V. Delgado-Escueta, Antonio V. Delgado-Escueta, Miyabi Tanaka, Miyabi Tanaka, Laurent Nguyen, Thierry Grisar, Thierry Grisar, Laurence de Nijs, Laurence de Nijs, Bernard Lakaye, Bernard Lakaye   +17 more
doaj   +1 more source