Results 51 to 60 of about 3,830 (141)

Importin-8 Modulates Division of Apical Progenitors, Dendritogenesis and Tangential Migration During Development of Mouse Cortex

Frontiers in Molecular Neuroscience, 2018
The building of the brain is a multistep process that requires the coordinate expression of thousands of genes and an intense nucleocytoplasmic transport of RNA and proteins.
Gerry Nganou, Gerry Nganou, Carla G. Silva, Ivan Gladwyn-Ng, Dominique Engel, Bernard Coumans, Bernard Coumans, Antonio V. Delgado-Escueta, Antonio V. Delgado-Escueta, Miyabi Tanaka, Miyabi Tanaka, Laurent Nguyen, Thierry Grisar, Thierry Grisar, Laurence de Nijs, Laurence de Nijs, Bernard Lakaye, Bernard Lakaye   +17 more
doaj   +1 more source

KPNA2 Drives Immunosuppression in Ovarian Cancer via CCL2/CCR2‐Dependent MDSC Recruitment

Cancer Science, Volume 117, Issue 9, Page 2461-2479, September 2026.
KPNA2 drives intratumoral MDSC accumulation and immunosuppression in ovarian cancer via the NF‐κB/CCL2/CCR2 axis. Mechanistically, KPNA2 facilitates NF‐κB/p65 nuclear translocation and induces CCL2 transcription, recruiting MDSCs to establish an immunosuppressive microenvironment.
Qingli Li, Jitong Zhao, Lu Yang, Lin Li, Ce Bian, Tao Yi, Huiqiong Huang, Gang Zheng, Xiaojuan Lin   +8 more
wiley   +1 more source

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, Volume 13, Issue 47, 24 August 2026.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

Targeting Spatiotemporal Heterogeneity of oncomiRNAs: A New Frontier in Cancer Therapy

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background miRNAs are short RNA transcripts that modulate gene expression after transcription and have emerged as pivotal regulators of cancer biology. A subset, termed oncomiRNAs, functions as oncogenes or tumor suppressors, influencing key cellular events such as cell growth, programmed cell death, neovascularization, tissue invasion, and ...
T. Jeethy Ram, Muralee Damodaran
wiley   +1 more source

Karyopherin abnormalities in neurodegenerative proteinopathies

, 2021
Neurodegenerative proteinopathies are characterized by progressive cell loss that is preceded by the mislocalization and aberrant accumulation of proteins prone to aggregation.
Zatorska, Anna, Rogelj, Boris, Pasha, Terouz, Sharipov, Daulet, Hortobágyi, Tibor; id_orcid, Hirth, Frank; id_orcid   +5 more
core   +1 more source

Pigment epithelium-derived factor (PEDF) interacts with transportin SR2, and active nuclear import is facilitated by a novel nuclear localization motif.

PLoS ONE, 2011
PEDF (Pigment epithelium-derived factor) is a non-inhibitory member of the serpin gene family (serpinF1) that displays neurotrophic and anti-angiogenic properties.
Sergio Anguissola, William J McCormack, Michelle A Morrin, Wayne J Higgins, Denise M Fox, D Margaret Worrall   +5 more
doaj   +1 more source

Multifaceted Roles of Chloroquines in Gastrointestinal Disorders and Beyond

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Chloroquine (CQ) and hydroxychloroquine (HCQ) modulate lysosomal activity and autophagy, suppressing gastrointestinal inflammation and reshaping pathogenic microbiota. These mechanisms alleviate inflammatory bowel disease, inhibit associated tumor growth, and provide benefits in certain autoimmune and viral conditions.
Sihyun Jeong, Eunsoo Kim, Yong Sung Kim, Eunok Im   +3 more
wiley   +1 more source

The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex

, 2011
The association of small, ubiquitin-related modifier–specific isopeptidases (also known as sentrin-specific proteases, or SENPs) with nuclear pore complexes (NPCs) is conserved in eukaryotic organisms ranging from yeast to mammals.
Debaditya Mukhopadhyay, Brian Raught, Pak-Kei Chan, Jacqueline Goeres, Michael J. Matunis, Hong Zhang   +5 more
core   +1 more source

Genome-Wide Localization of the Nuclear Transport Machinery Couples Transcriptional Status and Nuclear Organization [PDF]

, 2004
The association of genes with the nuclear pore complex (NPC) and nuclear transport factors has been implicated in transcriptional regulation. We therefore examined the association of components of the nuclear transport machinery including karyopherins ...
Christopher R Brown, Jason West, Brown, Christopher R, Hieronymus, Haley, Komili, Suzanne, Pamela A Silver, Silver, Pamela A, Jason M Casolari, Haley Hieronymus, Casolari, Jason M, Suzanne Komili, West, Jason   +11 more
core   +1 more source

The Ran pathway in Drosophila melanogaster mitosis

Frontiers in Cell and Developmental Biology, 2015
Over the last two decades, the small GTPase Ran has emerged as a central regulator of both mitosis and meiosis, particularly in the generation, maintenance and regulation of the microtubule (MT)-based bipolar spindle.
James G Wakefield, Jack Wei-Chu Chen, Amy eBarker, Amy eBarker   +3 more
doaj   +1 more source