Results 51 to 60 of about 3,763 (189)

HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport

eLife, 2020
HIV-1 must replicate in cells that are equipped to defend themselves from infection through intracellular innate immune systems. HIV-1 evades innate immune sensing through encapsidated DNA synthesis and encodes accessory genes that antagonize specific ...
Hataf Khan, Rebecca P Sumner, Jane Rasaiyaah, Choon Ping Tan, Maria Teresa Rodriguez-Plata, Chris Van Tulleken, Douglas Fink, Lorena Zuliani-Alvarez, Lucy Thorne, David Stirling, Richard SB Milne, Greg J Towers   +11 more
doaj   +1 more source

Auxiliary barrier function of karyopherins at the Nuclear Pore Complex [PDF]

, 2023
Nuclear pore complexes (NPCs) are highly selective gateways that mediate nucleocytoplasmic transport (NCT) in eukaryotic cells. Recent discoveries have shown that leaky NPCs and defective NCT are linked to aging, neurodegenerative disorders, and viral ...
Kalita, Joanna Małgorzata
core  

IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation

Journal of Experimental & Clinical Cancer Research, 2019
Background Karyopherin nuclear transport receptors play important roles in tumour development and drug resistance and have been reported as potential biomarkers and therapeutic targets for tumour treatment.
Wenjuan Zhang, Yanxia Lu, Xiaomin Li, Jianming Zhang, Weihao Lin, Wei Zhang, Lin Zheng, Xuenong Li   +7 more
doaj   +1 more source

The Karyopherin proteins, Crm1 and Karyopherin β1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation [PDF]

International Journal of Cancer, 2009
AbstractThe Karyopherin proteins are involved in nucleo‐cytoplasmic trafficking and are critical for protein and RNA subcellular localization. Recent studies suggest they are important in nuclear envelope component assembly, mitosis and replication. Since these are all critical cellular functions, alterations in the expression of the Karyopherins may ...
Pauline J, van der Watt, Christopher P, Maske, Denver T, Hendricks, M Iqbal, Parker, Lynette, Denny, Dhirendra, Govender, Michael J, Birrer, Virna D, Leaner   +7 more
openaire   +2 more sources

Importin-β modulates the permeability of the nuclear pore complex in a Ran-dependent manner

eLife, 2015
Soluble karyopherins of the importin-β (impβ) family use RanGTP to transport cargos directionally through the nuclear pore complex (NPC). Whether impβ or RanGTP regulate the permeability of the NPC itself has been unknown.
Alan R Lowe, Jeffrey H Tang, Jaime Yassif, Michael Graf, William YC Huang, Jay T Groves, Karsten Weis, Jan T Liphardt   +7 more
doaj   +1 more source

Positional scanning synthesis of a Peptoid library yields new inducers of apoptosis that target Karyopherins and Tubulin [PDF]

, 2015
We describe the synthesis of a library of 11 638 N-alkylglycine peptoid trimers in a positional scanning format with adjustment of reaction conditions to account for different reactivities of the monomer building blocks. Evaluation of the library by high-
Waldmann, H., Ziegler, S., Glòria Vendrell‐Navarro, Bujons, Jordi, Slava Ziegler, Janning, P., Angel Messeguer, Waldmann, Herbert, Rúa, Federico, Janning, Petra, Rúa, F., Andreas Brockmeyer, Bujons, J., Federico Rúa, Jordi Bujons, Ziegler, Slava, Herbert Waldmann, Vendrell Navarro, G., Messeguer, Angel, Messeguer, A., Brockmeyer, Andreas, Brockmeyer, A., Vendrell Navarro, Gloria, Petra Janning   +23 more
core   +1 more source

Viral Appropriation: Laying Claim to Host Nuclear Transport Machinery

Cells, 2019
Protein nuclear transport is an integral process to many cellular pathways and often plays a critical role during viral infection. To overcome the barrier presented by the nuclear membrane and gain access to the nucleus, virally encoded proteins have ...
Tanner M. Tessier, Mackenzie J. Dodge, Martin A. Prusinkiewicz, Joe S. Mymryk   +3 more
doaj   +1 more source

Brownian dynamics simulation of nucleocytoplasmic transport: a coarse-grained model for the functional state of the nuclear pore complex. [PDF]

PLoS Computational Biology, 2011
The nuclear pore complex (NPC) regulates molecular traffic across the nuclear envelope (NE). Selective transport happens on the order of milliseconds and the length scale of tens of nanometers; however, the transport mechanism remains elusive. Central to
Ruhollah Moussavi-Baygi, Yousef Jamali, Reza Karimi, Mohammad R K Mofrad   +3 more
doaj   +1 more source

The HIV capsid mimics karyopherin engagement of FG-nucleoporins. [PDF]

Nature
AbstractHIV can infect non-dividing cells because the viral capsid can overcome the selective barrier of the nuclear pore complex and deliver the genome directly into the nucleus1,2. Remarkably, the intact HIV capsid is more than 1,000 times larger than the size limit prescribed by the diffusion barrier of the nuclear pore3. This barrier in the central
Dickson CF, Hertel S, Tuckwell AJ, Li N, Ruan J, Al-Izzi SC, Ariotti N, Sierecki E, Gambin Y, Morris RG, Towers GJ, Böcking T, Jacques DA.   +12 more
europepmc   +6 more sources

KPNB1 (karyopherin (importin) beta 1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013
Review on KPNB1 (karyopherin (importin) beta 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Maria Giubettini, Pauline van der Watt, Annalisa Verrico, Valeria de Turris, Virna Leaner, Patrizia Lavia   +5 more
openaire   +3 more sources