Origin of the nucleus and Ran-dependent transport to safeguard ribosome biogenesis in a chimeric cell [PDF]
, 2008 Background: The origin of the nucleus is a central problem about the origin of eukaryotes. The common ancestry of nuclear pore complexes (NPC) and vesicle coating complexes indicates that the nucleus evolved via the modification of a pre-existing ...
Gáspár Jékely
core +1 more source
Viral Appropriation: Laying Claim to Host Nuclear Transport Machinery
Cells, 2019 Protein nuclear transport is an integral process to many cellular pathways and often plays a critical role during viral infection. To overcome the barrier presented by the nuclear membrane and gain access to the nucleus, virally encoded proteins have ...
Tanner M. Tessier +3 more
doaj +1 more source
Brownian dynamics simulation of nucleocytoplasmic transport: a coarse-grained model for the functional state of the nuclear pore complex. [PDF]
PLoS Computational Biology, 2011 The nuclear pore complex (NPC) regulates molecular traffic across the nuclear envelope (NE). Selective transport happens on the order of milliseconds and the length scale of tens of nanometers; however, the transport mechanism remains elusive. Central to
Ruhollah Moussavi-Baygi +3 more
doaj +1 more source
Inhibition of NUPR1–Karyopherin β1 Binding Increases Anticancer Drug Sensitivity [PDF]
International Journal of Molecular Sciences, 2021 Background: Nuclear protein-1 (NUPR1, also known as p8/Com-1) is a transcription factor involved in the regulation of cellular stress responses, including serum starvation and drug stimulation. Methods: We investigated the mechanism of NUPR1 nuclear translocation involving karyopherin β1 (KPNB1), using a single-molecule binding assay and confocal ...
Chanhee Park +6 more
openaire +3 more sources
Karyopherin α deficiency contributes to human preimplantation embryo arrest
Journal of Clinical Investigation, 2023 Preimplantation embryo arrest (PREMBA) is a common cause of female infertility and recurrent failure of assisted reproductive technology. However, the genetic basis of PREMBA is largely unrevealed. Here, using whole-exome sequencing data from 606 women experiencing PREMBA compared with 2,813 controls, we performed a population and gene-based burden ...
Wenjing Wang +31 more
openaire +3 more sources
The adapter importin‐α provides flexible control of nuclear import at the expense of efficiency
Molecular Systems Biology, 2007 Although there exists a large family of nuclear transport receptors (Karyopherins), the majority of known import cargoes use an adapter protein, Importin‐α (Impα), which links the cargo to a karyopherin, Importin‐β (Impβ). The reason for the existence of
Greg Riddick, Ian G Macara
doaj +1 more source
Evolutionarily Conserved Sequence Features Regulate the Formation of the FG Network at the Center of the Nuclear Pore Complex. [PDF]
, 2015 The nuclear pore complex (NPC) is the portal for bidirectional transportation of cargos between the nucleus and the cytoplasm. While most of the structural elements of the NPC, i.e.
Lee, BL +3 more
core +2 more sources
Roles of Cross-Membrane Transport and Signaling in the Maintenance of Cellular Homeostasis [PDF]
, 2016 Organelles allow specialized functions within cells to be localized, contained and independently regulated. This separation is oftentimes achieved by selectively permeable membranes, which enable control of molecular transport, signaling between ...
Inchul Cho, Joe Swift, Mark R. Jackson
core +2 more sources
Recognition of nuclear targeting signals by Karyopherin-β proteins [PDF]
Current Opinion in Structural Biology, 2010 The Karyopherin-β family of nuclear transport factors mediates the majority of nucleocytoplasmic transport. Although each of the 19 Karyopherin-βs transports unique sets of cargos, only three classes of nuclear localization and export signals, or NLSs and NESs, have been characterized. The short basic classical-NLS was first discovered in the 1980s and
Darui, Xu +2 more
openaire +2 more sources
Sequences within the C terminus of the metabotropic glutamate receptor 5 (mGluR5) are responsible for inner nuclear membrane localization [PDF]
, 2017 Traditionally, G-protein-coupled receptors (GPCR) are thought to be located on the cell surface where they transmit extracellular signals to the cytoplasm.
Harmon, Steven K. +4 more
core +2 more sources