Results 31 to 40 of about 3,763 (189)
HOX Protein Activity Regulation by Cellular Localization
Journal of Developmental Biology, 2021 While the functions of HOX genes have been and remain extensively studied in distinct model organisms from flies to mice, the molecular biology of HOX proteins remains poorly documented.
Laure Bridoux +2 more
doaj +1 more source
Karyopherins: potential biological elements involved in the delayed graft function in renal transplant recipients. [PDF]
, 2014 Background: Immediately after renal transplantation, patients experience rapid and significant improvement of their clinical conditions and undergo considerable systemic and cellular modifications.
Ancona N +9 more
core +2 more sources
C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import
eLife, 2020 Disruption of nucleocytoplasmic transport is increasingly implicated in the pathogenesis of neurodegenerative diseases, including ALS caused by a C9orf72 hexanucleotide repeat expansion. However, the mechanism(s) remain unclear.
Lindsey R Hayes +4 more
doaj +1 more source
Evaluation of the role of KPNA2 mutations in breast cancer prognosis using bioinformatics datasets
BMC Cancer, 2022 Breast cancer, comprising of several sub-phenotypes, is a leading cause of female cancer-related mortality in the UK and accounts for 15% of all cancer cases. Chemoresistant sub phenotypes of breast cancer remain a particular challenge.
Layla Alnoumas +6 more
doaj +1 more source
The Ebola Virus Interferon Antagonist VP24 Undergoes Active Nucleocytoplasmic Trafficking
Viruses, 2021 Viral interferon (IFN) antagonist proteins mediate evasion of IFN-mediated innate immunity and are often multifunctional, with distinct roles in viral replication.
Angela R. Harrison +3 more
doaj +1 more source
A Role for the Karyopherin Kap123p in Microtubule Stability [PDF]
Traffic, 2009 Several components of the nuclear transport machinery play a role in mitotic spindle assembly in higher eukaryotes. To further investigate the role of this family of proteins in microtubule function, we screened for mutations in Saccharomyces cerevisiae that confer sensitivity to microtubule‐destabilizing drugs.
Christopher, Ptak +7 more
openaire +2 more sources
Nucleocytoplasmic Trafficking Perturbation Induced by Picornaviruses
Viruses, 2021 Picornaviruses are positive-stranded RNA viruses. Even though replication and translation of their genome take place in the cytoplasm, these viruses evolved different strategies to disturb nucleocytoplasmic trafficking of host proteins and RNA. The major
Belén Lizcano-Perret, Thomas Michiels
doaj +1 more source
Computational and Structural Biotechnology Journal, 2022 Nuclear translocation of large proteins is mediated through karyopherins, carrier proteins recognizing specific motifs of cargo proteins, known as nuclear localization signals (NLS). However, only few NLS signals have been reported until now.
Athanasios A. Panagiotopoulos +10 more
doaj +1 more source
Nucleus, 2020 Xenopus egg extracts are a powerful in vitro tool for studying complex biological processes, including nuclear reconstitution, nuclear membrane and pore assembly, and spindle assembly.
Matthew S. Nord +5 more
doaj +1 more source