Journal of Experimental & Clinical Cancer Research, 2019 Background Karyopherin nuclear transport receptors play important roles in tumour development and drug resistance and have been reported as potential biomarkers and therapeutic targets for tumour treatment.
Wenjuan Zhang +7 more
doaj +1 more source
Auxiliary barrier function of karyopherins at the Nuclear Pore Complex [PDF]
, 2023 Nuclear pore complexes (NPCs) are highly selective gateways that mediate nucleocytoplasmic transport (NCT) in eukaryotic cells. Recent discoveries have shown that leaky NPCs and defective NCT are linked to aging, neurodegenerative disorders, and viral ...
Kalita, Joanna Małgorzata
core
Brownian dynamics simulation of nucleocytoplasmic transport: a coarse-grained model for the functional state of the nuclear pore complex. [PDF]
PLoS Computational Biology, 2011 The nuclear pore complex (NPC) regulates molecular traffic across the nuclear envelope (NE). Selective transport happens on the order of milliseconds and the length scale of tens of nanometers; however, the transport mechanism remains elusive. Central to
Ruhollah Moussavi-Baygi +3 more
doaj +1 more source
Importin-β modulates the permeability of the nuclear pore complex in a Ran-dependent manner
eLife, 2015 Soluble karyopherins of the importin-β (impβ) family use RanGTP to transport cargos directionally through the nuclear pore complex (NPC). Whether impβ or RanGTP regulate the permeability of the NPC itself has been unknown.
Alan R Lowe +7 more
doaj +1 more source
Nuclear Import and Export Signals of Human Cohesins SA1/STAG1 and SA2/STAG2 Expressed in Saccharomyces cerevisiae [PDF]
, 2012 Background: Human SA/STAG proteins, homologues of the yeast Irr1/Scc3 cohesin, are the least studied constituents of the sister chromatid cohesion complex crucial for proper chromosome segregation.
Jurek, Marta +27 more
core +1 more source
Viral Appropriation: Laying Claim to Host Nuclear Transport Machinery
Cells, 2019 Protein nuclear transport is an integral process to many cellular pathways and often plays a critical role during viral infection. To overcome the barrier presented by the nuclear membrane and gain access to the nucleus, virally encoded proteins have ...
Tanner M. Tessier +3 more
doaj +1 more source
Positional scanning synthesis of a Peptoid library yields new inducers of apoptosis that target Karyopherins and Tubulin [PDF]
, 2015 We describe the synthesis of a library of 11 638 N-alkylglycine peptoid trimers in a positional scanning format with adjustment of reaction conditions to account for different reactivities of the monomer building blocks. Evaluation of the library by high-
Waldmann, H. +23 more
core +1 more source
The adapter importin‐α provides flexible control of nuclear import at the expense of efficiency
Molecular Systems Biology, 2007 Although there exists a large family of nuclear transport receptors (Karyopherins), the majority of known import cargoes use an adapter protein, Importin‐α (Impα), which links the cargo to a karyopherin, Importin‐β (Impβ). The reason for the existence of
Greg Riddick, Ian G Macara
doaj +1 more source
Nuclear import of yeast Gcn4p requires karyopherins Srp1p and Kap95p
, 2004 The yeast transcription factor Gcn4p contains two stretches of amino acid residues, NLS1 and NLS2, which are independently able to relocate the cytoplasmic protein chorismate mutase into the nucleus. Only NLS2 is conserved among fungi.
Draht, Oliver W. +4 more
core +1 more source
Importins and Exportins Regulating Allergic Immune Responses
Mediators of Inflammation, 2014 Nucleocytoplasmic shuttling of macromolecules is a well-controlled process involving importins and exportins. These karyopherins recognize and bind to receptor-mediated intracellular signals through specific signal sequences that are present on cargo ...
Ankita Aggarwal, Devendra K. Agrawal
doaj +1 more source