Yeast 26S proteasome nuclear import is coupled to nucleus-specific degradation of the karyopherin adaptor protein Sts1 [PDF]
Scientific ReportsIn eukaryotes, the ubiquitin–proteasome system is an essential pathway for protein degradation and cellular homeostasis. 26S proteasomes concentrate in the nucleus of budding yeast Saccharomyces cerevisiae due to the essential import adaptor protein Sts1
Carolyn Allain Breckel +3 more
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Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A [PDF]
The EMBO JournalSphingosine and constrained analogs like FTY720 and SH-BC-893 restrain tumor growth through incompletely defined mechanisms that include protein phosphatase 2A (PP2A) activation.
Vaishali Jayashankar +25 more
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Karyopherins in the Remodeling of Extracellular Matrix: Implications in Tendon Injury [PDF]
Journal of Orthopaedics and Sports Medicine, 2023 Diaz C, Thankam FG, Agrawal DK.
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Karyopherin abnormalities in neurodegenerative proteinopathies [PDF]
Brain, 2021 Abstract Neurodegenerative proteinopathies are characterized by progressive cell loss that is preceded by the mislocalization and aberrant accumulation of proteins prone to aggregation. Despite their different physiological functions, disease-related proteins like tau, α-synuclein, TAR DNA binding protein-43, fused in sarcoma and mutant ...
Terouz Pasha +5 more
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HOX Protein Activity Regulation by Cellular Localization
Journal of Developmental Biology, 2021 While the functions of HOX genes have been and remain extensively studied in distinct model organisms from flies to mice, the molecular biology of HOX proteins remains poorly documented.
Laure Bridoux +2 more
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Cytoplasmic dynamics of the general nuclear import machinery in apically growing syncytial cells. [PDF]
PLoS ONE, 2013 Karyopherins are transporters involved in the bidirectional, selective and active transport of macromolecules through nuclear pores. Importin-β1 is the paradigm of karyopherins and, together with its cargo-adapter importin-α, mediates the general nuclear
Oier Etxebeste +4 more
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Characterization of the nuclear import mechanism of the CCAAT-regulatory subunit Php4. [PDF]
PLoS ONE, 2014 Php4 is a nucleo-cytoplasmic shuttling protein that accumulates in the nucleus during iron deficiency. When present in the nucleus, Php4 associates with the CCAAT-binding protein complex and represses genes encoding iron-using proteins.
Md Gulam Musawwir Khan +3 more
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C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import
eLife, 2020 Disruption of nucleocytoplasmic transport is increasingly implicated in the pathogenesis of neurodegenerative diseases, including ALS caused by a C9orf72 hexanucleotide repeat expansion. However, the mechanism(s) remain unclear.
Lindsey R Hayes +4 more
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CDK-dependent nuclear localization of B-Cyclin Clb1 promotes FEAR activation during meiosis I in budding yeast [PDF]
, 2013 Cyclin-dependent kinases (CDK) are master regulators of the cell cycle in eukaryotes. CDK activity is regulated by the presence, post-translational modification and spatial localization of its regulatory subunit cyclin.
A Sourirajan +38 more
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Evaluation of the role of KPNA2 mutations in breast cancer prognosis using bioinformatics datasets
BMC Cancer, 2022 Breast cancer, comprising of several sub-phenotypes, is a leading cause of female cancer-related mortality in the UK and accounts for 15% of all cancer cases. Chemoresistant sub phenotypes of breast cancer remain a particular challenge.
Layla Alnoumas +6 more
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