Results 11 to 20 of about 3,763 (189)
Ibetazol, a novel inhibitor of importin β1-mediated nuclear import [PDF]
Communications BiologyNucleocytoplasmatic transport plays an essential role in eukaryotic cell homeostasis and is mediated by karyopherins. Importin β1 (KPNB1) and its adaptor protein importin α1 (KPNA2) are the best-characterized karyopherins that effect nuclear import. Here,
Thomas Vercruysse +11 more
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Karyopherins in the Remodeling of Extracellular Matrix: Implications in Tendon Injury [PDF]
Journal of Orthopaedics and Sports Medicine, 2023 Rotator Cuff Tendinopathies (RCT) are debilitating conditions characterized by alterations in the extracellular matrix (ECM) of the shoulder tendon, resulting in pain, discomfort, and functional limitations. Specific mediators, including HIF-1α, TGF-β, MMP-9 and others have been implicated in the morphological changes observed in the tendon ECM.
exaly +4 more sources
Karyopherin abnormalities in neurodegenerative proteinopathies [PDF]
Brain, 2021 Abstract Neurodegenerative proteinopathies are characterized by progressive cell loss that is preceded by the mislocalization and aberrant accumulation of proteins prone to aggregation. Despite their different physiological functions, disease-related proteins like tau, α-synuclein, TAR DNA binding protein-43, fused in sarcoma and mutant ...
Terouz Pasha +5 more
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Adjunct Duties for Karyopherins: Regulating Septin Sumoylation [PDF]
Developmental Cell, 2007 Karyopherins are shuttling transport receptors regulated by the small GTPase Ran, which move cargo between the nucleus and cytoplasm by passing through the nuclear pore complexes. A recent paper in Journal of Cell Biology (Makhnevych et al., 2007) highlights an additional role for karyopherins during mitosis, in regulating the sumoylation status of the
Panse, Vikram Govind, Hurt, Ed
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Karyopherins play the field [PDF]
The Journal of Cell Biology, 2006 ![][1] Import of proteins (green) into the nucleus is slower than expected, revealing that karyopherins are choosy about their cargo. Proteins that shuttle molecules into the nucleus face the same problem as customers of a dating service.
Mitch Leslie
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Nuclear transport proteins: structure, function and disease relevance [PDF]
Signal Transduction and Targeted Therapy, 2023 Proper subcellular localization is crucial for the functioning of biomacromolecules, including proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the localization of many macromolecules within the nuclear or cytoplasmic
Yang Yang +5 more
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Importins/Karyopherins Meet Nucleoporins [PDF]
Cell, 1996 I thank Gunter Blobel, Valerie Doye, Dirk Gorlich, Iain Mattaj, Ulf Nehrbass, and Uli Scheer for helpful comments on the manuscript.
Hurt, E.C
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Take your mother’s ferry: preimplantation embryo development requires maternal karyopherins for nuclear transport [PDF]
The Journal of Clinical Investigation, 2023 The genetic basis of preimplantation embryo arrest is slowly being unraveled. Recent discoveries point to maternally expressed proteins required for cellular functions before the embryonic genome is activated. In this issue of the JCI, Wang, Miyamoto, et
Momal Sharif +2 more
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Characterization of the nuclear import mechanism of the CCAAT-regulatory subunit Php4. [PDF]
PLoS ONE, 2014 Php4 is a nucleo-cytoplasmic shuttling protein that accumulates in the nucleus during iron deficiency. When present in the nucleus, Php4 associates with the CCAAT-binding protein complex and represses genes encoding iron-using proteins.
Md Gulam Musawwir Khan +3 more
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Cytoplasmic dynamics of the general nuclear import machinery in apically growing syncytial cells. [PDF]
PLoS ONE, 2013 Karyopherins are transporters involved in the bidirectional, selective and active transport of macromolecules through nuclear pores. Importin-β1 is the paradigm of karyopherins and, together with its cargo-adapter importin-α, mediates the general nuclear
Oier Etxebeste +4 more
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