In vivo analysis of protein crowding within the nuclear pore complex in interphase and mitosis [PDF]
Scientific Reports, 2017 The central channel of the nuclear pore complex (NPC) is occupied by non-structured polypeptides with a high content of Phe-Gly (FG) motifs. This protein-rich environment functions as an entropic barrier that prevents the passage of molecules, as well as
Hide A. Konishi +3 more
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Cytoplasmic dynamics of the general nuclear import machinery in apically growing syncytial cells. [PDF]
PLoS ONE, 2013 Karyopherins are transporters involved in the bidirectional, selective and active transport of macromolecules through nuclear pores. Importin-β1 is the paradigm of karyopherins and, together with its cargo-adapter importin-α, mediates the general nuclear
Oier Etxebeste +4 more
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Characterization of the nuclear import mechanism of the CCAAT-regulatory subunit Php4. [PDF]
PLoS ONE, 2014 Php4 is a nucleo-cytoplasmic shuttling protein that accumulates in the nucleus during iron deficiency. When present in the nucleus, Php4 associates with the CCAAT-binding protein complex and represses genes encoding iron-using proteins.
Md Gulam Musawwir Khan +3 more
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Karyopherins: potential biological elements involved in the delayed graft function in renal transplant recipients. [PDF]
, 2014 Background: Immediately after renal transplantation, patients experience rapid and significant improvement of their clinical conditions and undergo considerable systemic and cellular modifications.
Ancona N +9 more
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C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import
eLife, 2020 Disruption of nucleocytoplasmic transport is increasingly implicated in the pathogenesis of neurodegenerative diseases, including ALS caused by a C9orf72 hexanucleotide repeat expansion. However, the mechanism(s) remain unclear.
Lindsey R Hayes +4 more
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Evaluation of the role of KPNA2 mutations in breast cancer prognosis using bioinformatics datasets
BMC Cancer, 2022 Breast cancer, comprising of several sub-phenotypes, is a leading cause of female cancer-related mortality in the UK and accounts for 15% of all cancer cases. Chemoresistant sub phenotypes of breast cancer remain a particular challenge.
Layla Alnoumas +6 more
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The Ebola Virus Interferon Antagonist VP24 Undergoes Active Nucleocytoplasmic Trafficking
Viruses, 2021 Viral interferon (IFN) antagonist proteins mediate evasion of IFN-mediated innate immunity and are often multifunctional, with distinct roles in viral replication.
Angela R. Harrison +3 more
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Nucleocytoplasmic Trafficking Perturbation Induced by Picornaviruses
Viruses, 2021 Picornaviruses are positive-stranded RNA viruses. Even though replication and translation of their genome take place in the cytoplasm, these viruses evolved different strategies to disturb nucleocytoplasmic trafficking of host proteins and RNA. The major
Belén Lizcano-Perret, Thomas Michiels
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iScience, 2023 Summary: Karyopherins mediate the movement between the nucleus and cytoplasm of specific proteins in diverse cellular processes. Through a loss-of-function approach, we here examine the role of Karyopherin Subunit Alpha 2 (Kpna2) in spermatogenesis ...
Paula Navarrete-López +6 more
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Nucleus, 2020 Xenopus egg extracts are a powerful in vitro tool for studying complex biological processes, including nuclear reconstitution, nuclear membrane and pore assembly, and spindle assembly.
Matthew S. Nord +5 more
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