Results 101 to 110 of about 4,908 (204)

Nanocarrier‐Based Systems for Targeted Delivery: Current Challenges and Future Directions

MedComm, Volume 6, Issue 9, September 2025.
Recent advances in nanocarrier‐mediated delivery for nuclear targeting Cell nucleus: key target for improved therapeutic outcomes including chemotherapy, photodynamic therapy, and gene therapy Nuclear‐targeted drug delivery strategy: including nuclear localization sequence (NLS)‐mediated active targeting and passive strategies • Challenges in nuclear ...
Zichen Xu, Yongyi Xie, Wenjie Chen, Wei Deng   +3 more
wiley   +1 more source

Intermolecular disulfide bonds among nucleoporins regulate karyopherin-dependent nuclear transport [PDF]

Journal of Cell Science, 2013
Disulfide (S-S) bonds play important roles in the regulation of protein function and cellular stress responses. In this study, we demonstrate that distinct sets of nucleoporins (Nups), components of the nuclear pore complex (NPC), form S-S bonds and regulate nuclear transport through the NPC.
Shige H, Yoshimura, Shotaro, Otsuka, Masahiro, Kumeta, Mariko, Taga, Kunio, Takeyasu   +4 more
openaire   +2 more sources

Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: Structural and mechanistic insights [PDF]

, 2013
Phosphorylation adjacent to nuclear localization signals (NLSs) is involved in the regulation of nucleocytoplasmic transport. The nuclear isoform of human dUTPase, an enzyme that is essential for genomic integrity, has been shown to be phosphorylated on ...
Adams, Anna Erdei, Anna Magyar, Beeckmans, Beáta G. Vértessy, Bostjan Kobe, Bozóky, Békési, Chen, Cowtan, Duncan, Emsley, Enikő Takács, Enquist-Newman, Falces, Fontes, Fontes, Fontes, Fornerod, Fruzsina Babos, Gadsden, Galperin, Gergely Róna, Geymonat, Görlich, Hagen, Harreman, Hennekes, Huynh, Ikuta, Ildikó Scheer, Jans, Jans, Jans, Jaquenoud, Judit Tóth, Kabsch, Kaffman, Koehler, Kosugi, Kovári, Ladner, Ladner, Ladner, Lange, Lee, Liku, László Buday, MacFarlane, Marfori, Marfori, Mary Marfori, McCoy, McPhillips, Merényi, Mol, Moll, Muha, Muha, Máté Borsos, Nagy, Nardozzi, Németh-Pongrácz, Pecsi, Pecsi, Poon, Pécsi, Sidorova, Stephen, Tagawa, Takács, Takács, Tarrant, Tinkelenberg, Tóth, Varga, Vértessy, Winn, Zhou, Zoltán Bozóky   +79 more
core   +1 more source

Metabolic Reprogramming: A Crucial Contributor to Anticancer Drug Resistance

MedComm, Volume 6, Issue 9, September 2025.
Role of metabolic reprogramming in drug resistance in cancer: Metabolic reprogramming in cancer cells profoundly impacts the responsiveness of these cells to drugs. Cancer cells rewire the flux of the metabolism of the three major nutrients, glucose, lipid, and amino acids, leading to abnormalities in drug orientation, defects in cell death mechanisms,
Yunhan Zhu, Weijie Yan, Lingfeng Tong, Jie Yang, Shengfang Ge, Jiayan Fan, Renbing Jia, Xuyang Wen   +7 more
wiley   +1 more source

A 3D Physical Model of Karyopherin‐β2

The FASEB Journal, 2012
Karyopherin beta 2 (Kapβ2) is an importin that transports various cargo proteins into the nucleus through interactions with nucleoporins, which are proteins of the nuclear pore complex (NPC). One might overlook the significance of this protein but it actually plays a crucial role in the human body.
Mary Acheampong, Rosieva Ashong-Katia, Kavita Bhikhi, Daviana Dueno, Bobby Glover, Lachoy Harris, Alafia Henry, Randol Mata, Hillary Ramirez, Marisa VanBrakle, Allison Granberry, Natalia E. Ketaren, Michael P. Rout   +12 more
openaire   +1 more source

Investigating Ebola virus pathogenicity using molecular dynamics

BMC Genomics, 2017
Background Ebolaviruses have been known to cause deadly disease in humans for 40 years and have recently been demonstrated in West Africa to be able to cause large outbreaks.
Morena Pappalardo, Francesca Collu, James Macpherson, Martin Michaelis, Franca Fraternali, Mark N. Wass   +5 more
doaj   +1 more source

Developmental regulation of the heat shock response by nuclear transport factor karyopherin-α3 [PDF]

, 2001
During early stages of Drosophila development the heat-shock response cannot be induced. It is reasoned that the adverse effects on cell cycle and cell growth brought about by Hsp70 induction must outweigh the beneficial aspects of Hsp70 induction in the
Chen, Tianxin, Fang, Xiang-dong, Parker, Carl S., Tran, Kim   +3 more
core  

A cellular model of TDP‐43 induces phosphorylated TDP‐43 aggregation with distinct changes in solubility and autophagy dysregulation

The FEBS Journal, Volume 292, Issue 18, Page 4870-4897, September 2025.
TDP‐43 protein plays a pathological role in sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we developed a cellular model overexpressing TDP‐43 with three mutations linked to familial ALS, termed ‘3X‐TDP‐43’. Mutant 3X‐TDP‐43 expression showed deficits in autophagy flux and colocalization with stress granules.
Matthew B. Dopler, Muhammad I. Abeer, Sanaz Arezoumandan, Keyshawn Cox, Tyler L. Petersen, Esther H. Daniel, Carlton L. Cannon III, Angelica Bautista, Kennedy D. Blancher, Alysia M. Bland, Kylie J. Bond, Dominque A. Davis, Jessica M. Francois, Eliana J. McCray, Justin M. Morgan, Jessica L. Pulliam, Zymir A. Robinson, Mykia J. Taylor, James A. Dowell, Nigel J. Cairns, Michael A. Gitcho   +20 more
wiley   +1 more source

Components and regulation of nuclear transport processes [PDF]

, 2015
The spatial separation of DNA replication and gene transcription in the nucleus and protein translation in the cytoplasm is a uniform principle of eukaryotic cells. This compartmentalization imposes a requirement for a transport network of macromolecules
Alefantis, Argentaro, Arnaoutov, Arts, Arts, Askjaer, Bardina, Bayliss, Beals, Beck, Bednenko, Beg, Belov, Bernad, Bischoff, Bogerd, Bohnsack, Bohnsack, Bono, Bourne, Brickner, Bui, Bunn, Calado, Callan, Caly, Capelson, Carmody, Castello, Cautain, Chen, Chook, Ciufo, Conti, Conti, Cook, Cour, Craig, Cronshaw, Debler, Devos, Dingwall, Dong, Dong, Dorfman, Englmeier, Erickson, Erkmann, Ertel, Feng, Ferrigno, Field, Fineberg, Fischer, Fontoura, Fornerod, Fornerod, Frey, Frey, Fried, Frieman, Fu, Fu, Fukuda, Fukuda, Gadal, Ghildyal, Goldfarb, Gontan, Gorlich, Gorlich, Grespin, Grossman, Gustin, Gustin, Guttler, Hall, Harel, Hellmuth, Henderson, Hill, Hill, Ho, Hoelz, Holaska, Hopper, Huang, Huber, Hubner, Hung, Hussain, Hutten, Hutten, Isgro, Izaurralde, Kalab, Kalderon, Kalderon, Katahira, Kehlenbach, Kehlenbach, Kobbe, Kohler, Komeili, Kopecky-Bromberg, Kosugi, Kosugi, Kosugi, Krull, Kunzler, Kunzler, Kurisaki, Kutay, Kutay, Lam, Lange, Lange, Lange, Lee, Lee, Lidsky, Lim, Lim, Lim, Lim, Lindsay, Long, Luna, Lund, Macara, Maimon, Makkerh, Malik, Malim, Malim, Malim, Malim, Marfori, Mateo, Maurer, Melchior, Melcák, Mingot, Mingot, Mitchell, Monecke, Moore, Moore, Mor, Mosammaparast, Murdoch, Nemergut, Neumann, Ohno, Ossareh-Nazari, Paraskeva, Park, Peters, Porter, Prieto, Ren, Rexach, Ribbeck, Richards, Riviere, Rodriguez, Rodriguez-Navarro, Rouquette, Rout, Rout, Sarma, Schwartz, Shabman, Shin, Shuai, Siddiqui, Solsbacher, Sorokin, Speese, Stade, Stommel, Strambio-De-Castillia, Suel, Therizols, Thomas, Traenckner, Tran, Truant, Turner, Turner, Vosse, Wagstaff, Walther, Watters, Weighardt, Wen, Wen, Wente, Wild, Xu, Xu, Yang, Yi, Zanella   +203 more
core   +1 more source

Kapβ2 Reverses Sevoflurane‐Induced Hydrogel Phase Transition of hnRNPA2/B1‐SG in Hypoxic Primary Rat Hippocampal Neurons

CNS Neuroscience &Therapeutics, Volume 31, Issue 8, August 2025.
Sevoflurane exacerbates hippocampal neuronal dysfunction under hypoxic conditions by inducing the cytoplasmic mislocalization of hnRNPA2/B1, which drives abnormal liquid–liquid phase separation (LLPS) and subsequent irreversible hydrogel transition of hnRNPA2/B1‐containing stress granules (SGs).
Miao Zhang, Xinyi Wang, Feiyu Jia, Chenyi Yang, Zixuan Wang, Huihui Liao, Lin Zhang, Xi Xin, Haiyun Wang   +8 more
wiley   +1 more source