Results 111 to 120 of about 4,908 (204)
Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone. [PDF]
, 2019 We report the crystal structure of nuclear import receptor Importin-9 bound to its cargo, the histones H2A-H2B. Importin-9 wraps around the core, globular region of H2A-H2B to form an extensive interface.
Brautigam, Chad A +9 more
core +1 more source
MiR‐20a‐5p Inhibits Bladder Cancer Proliferation and Migration by Targeting KPNA2
Journal of Cellular and Molecular Medicine, Volume 29, Issue 16, August 2025.ABSTRACT Bladder cancer (BC) is one of the 10 most common cancers in the world, and its recurrence and metastasis are the main causes of death in BC patients. Exploring the molecular mechanisms of BC pathogenesis and searching for new prognostic markers and therapeutic targets are important for improving patient prognosis.
Shuai Ye +7 more
wiley +1 more source
BioEssays, Volume 47, Issue 7, July 2025.Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley +1 more source
The Structure Inventory of the Nuclear Pore Complex [PDF]
, 2018 The nuclear pore complex (NPC) is the principal gateway for molecular exchange between nucleus and cytoplasm across the nuclear envelope. Due to its sheer size of estimated 50-112 MDa and its complex buildup from about 500-1000 individual proteins, it is
Schwartz, Thomas
core +1 more source
Yeast karyopherin Kap95 is required for cell cycle progression at Start
BMC Cell Biology, 2010 Background The control of the subcellular localization of cell cycle regulators has emerged as a crucial mechanism in cell division regulation. The active transport of proteins between the nucleus and the cytoplasm is mediated by the transport receptors ...
Igual Juan, Taberner Francisco
doaj +1 more source
Metabolism and function of hepatitis B virus cccDNA: Implications for the development of cccDNA-targeting antiviral therapeutics. [PDF]
, 2015 Persistent hepatitis B virus (HBV) infection relies on the stable maintenance and proper functioning of a nuclear episomal form of the viral genome called covalently closed circular (ccc) DNA.
Guo, Haitao, Guo, Ju-Tao
core +1 more source
BMC Genetics, 2002 Background The Mitotic Exit Network (MEN) proteins – including the protein kinase Cdc15 and the protein phosphatase Cdc14 – are essential for exit from mitosis in Saccharomyces cerevisiae.
Deshaies Raymond J, Shou Wenying
doaj +1 more source
Membrane-coating lattice scaffolds in the nuclear pore and vesicle coats: Commonalities, differences, challenges [PDF]
, 2011 The nuclear pore complex (NPC) regulates all traffic between the cytoplasm and the nucleus. It is a large protein assembly composed of multiple copies of ~30 nucleoporins (nups).
Leksa, Nina Carolina, Schwartz, Thomas
core +1 more source
Cell Communication and Signaling, 2019 Background Members of the karyopherin superfamily serve as nuclear transport receptors/adaptor proteins and provide exchange of macromolecules between the nucleo- and cytoplasm.
Elisabeth Drucker +12 more
doaj +1 more source
Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution
Biology Direct, 2010 Background The transition from prokaryotes to eukaryotes was the most radical change in cell organisation since life began, with the largest ever burst of gene duplication and novelty.
Cavalier-Smith Thomas
doaj +1 more source