Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution
Biology Direct, 2010 Background The transition from prokaryotes to eukaryotes was the most radical change in cell organisation since life began, with the largest ever burst of gene duplication and novelty.
Cavalier-Smith Thomas
doaj +1 more source
, 2004 The association of genes with the nuclear pore complex (NPC) and nuclear transport factors has been implicated in transcriptional regulation. We therefore examined the association of components of the nuclear transport machinery including karyopherins ...
Christopher R Brown +11 more
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The distribution of karyopherin β proteins in Alzheimer's disease
The FASEB Journal, 2008 Electron microscopic studies of Alzheimer's disease (AD) revealed an intimate relationship between paired helical filaments and nuclear pores, structures with a key role in bidirectional nucleocytoplasmic transport. This association led us to explore potential abnormalities in transport that may contribute to tangle formation and other protein ...
Lynette G Sheffield, Suzanne S Mirra
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Bcp1 is the nuclear chaperone of Rpl23 in Saccharomyces cerevisiae [PDF]
, 2017 Eukaryotic ribosomes are composed of rRNAs and ribosomal proteins. Ribosomal proteins are translated in the cytoplasm and imported into the nucleus for assembly with the rRNAs.
Ting, Ya Han +6 more
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Karyopherin α2 is a maternal effect gene required for early embryonic development and female fertility in mice [PDF]
The nuclear transport of proteins plays an important role in mediating the transition from egg to embryo and distinct karyopherins have been implicated in this process. Here, we studied the impact of KPNA2 deficiency on preimplantation embryo development
Depping, R. +6 more
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Virology, 2000 We searched for cellular proteins that interact with Epstein-Barr (EBV) virus nuclear antigen-1, which is a latent EBV origin-binding protein detected in all EBV latently infected cells and essential for maintenance of the latent EBV genome, by a yeast two-hybrid screening of a B lymphocyte cDNA library in this study.
Ito, Sayuri +6 more
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Analysis of Regulation of Major Mitotic Assembly Events In Vitro by Nuclear Import and Export Receptors [PDF]
, 2018 This dissertation is an analysis of regulation of major mitotic assembly events by nuclear transport receptors, or karyopherins. Karyopherins, composed of both importins and exportins, are a large family of proteins that transport specific proteins and ...
Nord, Matthew
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Identification of nucleocytoplasmic transport signals in Rps15 and Ltv1, two proteins related to small ribosomal subunit export [PDF]
, 2020 [EN] Ribosomes are indispensable organelles for cell survival. Eukaryotic ribosomes are made up of two subunits (60S and 40S), which are independently exported from the nucleolus to the cytoplasm, where they are finally assembled to form the functional ...
González Benito, Adriana
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FUNCTIONAL AND MECHANISTIC CHARACTERIZATION OF THE NUCLEAR IMPORT RECEPTOR KARYOPHERIN-α2 IN LIVER CANCER [PDF]
, 2019 Exchange of macromolecules between the nucleo- and cytoplasm is provided by the nuclear transport system (NTS). Karyopherins represent essential components of NTS) by serving as nuclear transport receptors/adaptor proteins.
Drucker, Elisabeth
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Characterization of the mechanism of action of Transportin in mitotic spindle assembly [PDF]
, 2011 In eukaryotic cells, proteins known as karyopherins function during interphase as nuclear import and export receptors. Importin [beta] and Transportin, two such karyopherins, act to carry proteins with different recognition sites into the interphase ...
Swift-Taylor, Mary Elizabeth
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