The Mammalian Cell Cycle Regulates Parvovirus Nuclear Capsid Assembly. [PDF]
, 2015 It is unknown whether the mammalian cell cycle could impact the assembly of viruses maturing in the nucleus. We addressed this question using MVM, a reference member of the icosahedral ssDNA nuclear parvoviruses, which requires cell proliferation to ...
Almendral, JM +5 more
core +7 more sources
The karyopherin CRM1 is required for dendritic cell maturation
Immunobiology, 2010 Dendritic cells (DC) are the most potent antigen-presenting cells (APC) of the immune system and are specialized to activate T as well as B cell-dependent immune responses. Mature DC are characterized by expression of CD83, a surface molecule that has been postulated to be required for efficient DC activity.
Jan, Chemnitz +4 more
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Cell Host-Microbe Interactions: Turning Pathogen Mechanisms Into Cell's Advantages [PDF]
, 2013 Host-Pathogen Interaction is a very vast field of biological sciences, indeed every year many un- known pathogens are uncovered leading to an exponential growth of this field.
Avanzi, Simone <1982>
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Dynamics of re-constitution of the human nuclear proteome after cell division is regulated by NLS-adjacent phosphorylation [PDF]
, 2014 Phosphorylation by the cyclin-dependent kinase 1 (Cdk1) adjacent to nuclear localization signals (NLSs) is an important mechanism of regulation of nucleocytoplasmic transport. However, no systematic survey has yet been performed in human cells to analyze
Bodaen, Mikael +13 more
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Calcium mediated regulation of karyopherin nuclear transport receptors
The FASEB Journal, 2013 Oxidative stress disrupts the normal function of cells and severe stress situations can result in apoptosis. A specific effect of oxidant stress is an increase in cellular calcium levels, which can be mimicked by treatment with the drug thapsigargin, which inhibits Ca 2+ uptake into the ...
Lauren Elizabeth Foltz +3 more
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RanGAP1 is a continuous marker of the Arabidopsis cell division plane [PDF]
, 2008 In higher plants, the plane of cell division is faithfully predicted by the preprophase band (PPB). The PPB, a cortical ring of microtubules and F-actin, disassembles upon nuclear-envelope breakdown.
X. M. Xu +21 more
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The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus [PDF]
, 2010 Expansion of a polyglutamine (polyQ) tract in the Huntingtin (Htt) protein causes Huntington's disease (HD), a fatal inherited neurodegenerative disorder.
Baquet +74 more
core +4 more sources
Regulation of cell cycle transcription factor Swi5 by karyopherin Msn5
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012 Inactivation of S. cerevisiae β-karyopherin Msn5 causes hypersensitivity to the overexpression of mitotic cyclin Clb2 and aggravates growth defects of many mutant strains in mitotic exit, suggesting a connection between Msn5 and mitotic exit. We determined that Msn5 controlled subcellular localization of the mitotic exit transcription factor Swi5 ...
Taberner, Francisco José +4 more
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ARHI (DIRAS 3), an Imprinted Tumor Suppressor Gene, Binds to Importins, and Blocks Nuclear Translocation of Stat3 [PDF]
, 2008 ARHI (DIRAS3) is an imprinted tumor suppressor gene whose expression is lost in the majority of breast and ovarian cancers. Unlike its homologs Ras and Rap, ARHI functions as a tumor suppressor.
In Soon Chang +11 more
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Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source