Results 11 to 20 of about 27,476 (204)
Nucleocytoplasmic transport: taking an inventory [PDF]
Cellular and Molecular Life Sciences (CMLS), 2018 In eukaryotic cells, the enclosure of the genetic information in the nucleus allows the spatial and temporal separation of DNA replication and transcription from cytoplasmic protein synthesis.
Fried, H., Kutay, U.
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Coupling of Perinuclear Actin Cap and Nuclear Mechanics in Regulating Flow‐Induced Yap Spatiotemporal Nucleocytoplasmic Transport [PDF]
Advanced ScienceMechanical forces, including flow shear stress, govern fundamental cellular processes by modulating nucleocytoplasmic transport of transcription factors like Yes‐associated Protein (YAP). However, the underlying mechanical mechanism remains elusive.
Tianxiang Ma +22 more
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Karyopherin-mediated nucleocytoplasmic transport. [PDF]
Nat Rev Mol Cell Biol, 2022 Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of the macromolecular traffic across the nuclear pores is mediated by the Karyopherin-β (or Kap) family of nuclear transport receptors.
Wing CE, Fung HYJ, Chook YM.
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Higher nucleoporin-Importinβ affinity at the nuclear basket increases nucleocytoplasmic import. [PDF]
, 2013 Several in vitro studies have shown the presence of an affinity gradient in nuclear pore complex proteins for the import receptor Importinβ, at least partially contributing to nucleocytoplasmic transport, while others have historically argued against the
Azimi, Mohammad, Mofrad, Mohammad
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Nucleocytoplasmic Transport [PDF]
Science, 1996 Active transport of proteins and RNAs between the nucleus and cytoplasm is a major process in eukaryotic cells. Recently, factors that recognize transport substrates and mediate nuclear import or export have been characterized, revealing interactions that target substrates to the nuclear pore complexes, through which translocation occurs. Translocation
Görlich, D., Mattaj, I.
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The bioenergetics of nucleocytoplasmic transport. [PDF]
J Cell BiolHow nucleocytoplasmic transport (NCT) rates change due to cellular physiology-mediated fluctuations in GTP availability remains unclear. In this issue, Scott et al. (https://doi.org/10.1083/jcb.202308152) demonstrate that cell migration, spreading, and nucleocytoskeletal coupling impact GTP levels, thereby regulating NCT, RNA export, and protein ...
Luxton GWG.
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Cells, 2021 The host nucleocytoplasmic trafficking system is often hijacked by viruses to accomplish their replication and to suppress the host immune response.
Elma Sakinatus Sajidah +2 more
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Reversibility in nucleocytoplasmic transport [PDF]
Proceedings of the National Academy of Sciences, 2007 Nucleocytoplasmic exchange of proteins and RNAs is mediated by receptors that usher their cargo through the nuclear pores. Peptide localization signals on each cargo determine the receptors with which it will interact. Those interactions are normally regulated by the small GTPase Ran.
Ronen Benjamine, Kopito, Michael, Elbaum
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Frontiers in Bioengineering and Biotechnology, 2022 Electroporation-based technologies using microsecond pulsed electric field (µsPEF) exposures are established as laboratory and clinical tools that permeabilize cell membranes.
Zahra Safaei, Gary L. Thompson
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SCARB1 downregulation in adrenal insufficiency with Allgrove syndrome
Orphanet Journal of Rare Diseases, 2023 Background Allgrove disease is a rare genetic syndrome characterized by adrenal insufficiency, alacrimia, achalasia and complex neurological involvement.
Giacomo Bitetto +9 more
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