Results 11 to 20 of about 14,540 (195)
Viral interference of nucleocytoplasmic transport. [PDF]
J Biol ChemViruses have evolved diverse strategies to exploit the compartmentalized architecture of eukaryotic cells, particularly by targeting the nuclear envelope (NE) and its associated nuclear pore complexes (NPCs). The NE, composed of a double-membrane lipid bilayer, NPCs, and the nuclear lamina, establishes a physical barrier that protects genetic material ...
Chien CY +3 more
europepmc +3 more sources
Nucleocytoplasmic Transport: Navigating the Channel [PDF]
Traffic, 2003 Nucleocytoplasmic transport is mediated by shuttling receptors that recognize specific signals on protein or RNA cargoes and translocate the cargoes through the nuclear pore complex. Transport receptors appear to move through the nuclear pore complex by facilitated diffusion, involving repeated cycles of binding to and dissociation from nucleoporins ...
Janna Bednenko, Gino Cingolani
exaly +3 more sources
Efficiency, selectivity, and robustness of nucleocytoplasmic transport. [PDF]
PLoS Computational Biology, 2007 All materials enter or exit the cell nucleus through nuclear pore complexes (NPCs), efficient transport devices that combine high selectivity and throughput. NPC-associated proteins containing phenylalanine-glycine repeats (FG nups) have large, flexible,
Anton Zilman +4 more
doaj +4 more sources
Coupling of Perinuclear Actin Cap and Nuclear Mechanics in Regulating Flow‐Induced Yap Spatiotemporal Nucleocytoplasmic Transport [PDF]
Advanced ScienceMechanical forces, including flow shear stress, govern fundamental cellular processes by modulating nucleocytoplasmic transport of transcription factors like Yes‐associated Protein (YAP). However, the underlying mechanical mechanism remains elusive.
Tianxiang Ma +22 more
doaj +2 more sources
Nucleocytoplasmic Transport: Regulatory Mechanisms and the Implications in Neurodegeneration [PDF]
International Journal of Molecular Sciences, 2021 Baojin Ding, Masood Sepehrimanesh
exaly +2 more sources
Nucleocytoplasmic Transport [PDF]
Science, 1996 Active transport of proteins and RNAs between the nucleus and cytoplasm is a major process in eukaryotic cells. Recently, factors that recognize transport substrates and mediate nuclear import or export have been characterized, revealing interactions that target substrates to the nuclear pore complexes, through which translocation occurs. Translocation
Görlich, D., Mattaj, I.
openaire +3 more sources
Reversibility in nucleocytoplasmic transport [PDF]
Proceedings of the National Academy of Sciences, 2007 Nucleocytoplasmic exchange of proteins and RNAs is mediated by receptors that usher their cargo through the nuclear pores. Peptide localization signals on each cargo determine the receptors with which it will interact. Those interactions are normally regulated by the small GTPase Ran.
Ronen Benjamine, Kopito, Michael, Elbaum
openaire +2 more sources
Cells, 2021 The host nucleocytoplasmic trafficking system is often hijacked by viruses to accomplish their replication and to suppress the host immune response.
Elma Sakinatus Sajidah +2 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Electroporation-based technologies using microsecond pulsed electric field (µsPEF) exposures are established as laboratory and clinical tools that permeabilize cell membranes.
Zahra Safaei, Gary L. Thompson
doaj +1 more source
Quantitative Nucleocytoplasmic Transport Assays in Cellular Models of Neurodegeneration
Bio-Protocol, 2020 Nucleocytoplasmic transport deficits are suggested to play a role in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Given the importance and complexity of this process, understanding when these aberrations occur and which ...
Joni Vanneste +4 more
doaj +1 more source