Results 21 to 30 of about 15,740 (146)
Mechanical force application to the nucleus regulates nucleocytoplasmic transport. [PDF]
Nat Cell Biol, 2022 Mechanical force controls fundamental cellular processes in health and disease, and increasing evidence shows that the nucleus both experiences and senses applied forces.
Andreu I +11 more
europepmc +2 more sources
Cellular Stress Induces Nucleocytoplasmic Transport Deficits Independent of Stress Granules. [PDF]
Biomedicines, 2022 Stress granules are non-membrane bound granules temporarily forming in the cytoplasm in response to stress. Proteins of the nucleocytoplasmic transport machinery were found in these stress granules and it was suggested that stress granules contribute to ...
Vanneste J +5 more
europepmc +2 more sources
C9orf72 dipeptides disrupt the nucleocytoplasmic transport machinery and cause TDP-43 mislocalisation to the cytoplasm. [PDF]
Sci Rep, 2022 A repeat expansion in C9orf72 is the major cause of both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), accounting for approximately 1 in 12 cases of either disease.
Ryan S +3 more
europepmc +2 more sources
Nucleocytoplasmic transport: factors and mechanisms
FEBS Letters, 1995 In the past two years, our knowledge concerning the mechanisms of nucleocytoplasmic transport through the nuclear pore complex (NPC) has considerably expanded.
George Simos +3 more
core +3 more sources
The role of nucleocytoplasmic transport in mechanotransduction
Experimental Cell Research, 2019 Cells integrate mechanical and biochemical signals via a process called mechanotransduction to generate essential gene expression patterns in space and time.
Lim, Roderick Y. H. +2 more
core +5 more sources
Efficiency, selectivity, and robustness of nucleocytoplasmic transport.
PLoS Computational Biology, 2007 All materials enter or exit the cell nucleus through nuclear pore complexes (NPCs), efficient transport devices that combine high selectivity and throughput. NPC-associated proteins containing phenylalanine-glycine repeats (FG nups) have large, flexible,
Stefano Di Talia +9 more
core +5 more sources
Nucleocytoplasmic Transport: Regulatory Mechanisms and the Implications in Neurodegeneration [PDF]
International Journal of Molecular Sciences, 2021 Baojin Ding +2 more
exaly +2 more sources
Nucleocytoplasmic Transport [PDF]
Science, 1996 Active transport of proteins and RNAs between the nucleus and cytoplasm is a major process in eukaryotic cells. Recently, factors that recognize transport substrates and mediate nuclear import or export have been characterized, revealing interactions that target substrates to the nuclear pore complexes, through which translocation occurs. Translocation
Görlich, D., Mattaj, I.
openaire +3 more sources
Karyopherin-mediated nucleocytoplasmic transport. [PDF]
Nat Rev Mol Cell Biol, 2022 Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of the macromolecular traffic across the nuclear pores is mediated by the Karyopherin-β (or Kap) family of nuclear transport receptors.
Wing CE, Fung HYJ, Chook YM.
europepmc +3 more sources
Viral interference of nucleocytoplasmic transport. [PDF]
J Biol ChemViruses have evolved diverse strategies to exploit the compartmentalized architecture of eukaryotic cells, particularly by targeting the nuclear envelope (NE) and its associated nuclear pore complexes (NPCs). The NE, composed of a double-membrane lipid bilayer, NPCs, and the nuclear lamina, establishes a physical barrier that protects genetic material ...
Chien CY +3 more
europepmc +3 more sources