Results 21 to 30 of about 2,127,287 (180)

Histone deacetylase 4 and 5 translocation elicited by microsecond pulsed electric field exposure is mediated by kinase activity

Frontiers in Bioengineering and Biotechnology, 2022
Electroporation-based technologies using microsecond pulsed electric field (µsPEF) exposures are established as laboratory and clinical tools that permeabilize cell membranes.
Zahra Safaei, Gary L. Thompson
doaj   +1 more source

SCARB1 downregulation in adrenal insufficiency with Allgrove syndrome

Orphanet Journal of Rare Diseases, 2023
Background Allgrove disease is a rare genetic syndrome characterized by adrenal insufficiency, alacrimia, achalasia and complex neurological involvement.
Giacomo Bitetto, Gianluca Lopez, Dario Ronchi, Alessandra Pittaro, Valentina Melzi, Erika Peverelli, Fulvia Milena Cribiù, Giacomo P. Comi, Giovanna Mantovani, Alessio Di Fonzo   +9 more
doaj   +1 more source

Controlling protein transport by small molecules [PDF]

, 2011
Many proteins are transported from the nucleus to the cytoplasm by the exportin CRM1, which recognizes cargo proteins through a leucine rich nuclear export signal (NES).
Karl Gademann, Gademann, Karl
core   +1 more source

Nucleocytoplasmic Transport: Regulatory Mechanisms and the Implications in Neurodegeneration. [PDF]

Int J Mol Sci, 2021
Ding B, Sepehrimanesh M.
europepmc   +2 more sources

Role of Nucleoporins and Transport Receptors in Cell Differentiation

Frontiers in Physiology, 2020
Bidirectional molecular movements between the nucleus and cytoplasm take place through nuclear pore complexes (NPCs) embedded in the nuclear membrane.
Asmat Ullah Khan, Rongmei Qu, Jun Ouyang, Jingxing Dai   +3 more
doaj   +1 more source

Reduction of dimensionality in Karyopherinβ1 mediated transport on FG domains [PDF]

, 2014
Many molecular transport processes in living cells proceed by facilitated diffusion in two dimensions instead of three, but how this process works remains poorly understood.
Schleicher, Kai D.
core   +1 more source

Nuclear Exportin 1 (XPO1) Binds to the Nuclear Localization/Export Signal of the Turnip Mosaic Virus NIb to Promote Viral Infection

Frontiers in Microbiology, 2022
The nuclear localization signal (NLS) and nuclear export signal (NES) are key signatures of proteins for controlling nuclear import and export. The NIb protein of turnip mosaic virus (TuMV) is an RNA-dependent RNA polymerase (RdRP) that is absolutely ...
Mingzhen Zhang, Pan Gong, Linhao Ge, Yinzi Li, Yinzi Li, Zhaoyang Chang, Rui Qiao, Xueping Zhou, Xueping Zhou, Aiming Wang, Aiming Wang, Fangfang Li   +11 more
doaj   +1 more source

Respiratory virus modulation of host nucleocytoplasmic transport; target for therapeutic intervention?

Frontiers in Microbiology, 2015
The respiratory diseases caused by Rhinovirus, Respiratory Syncytial Virus and Influenza virus represent a large social and financial burden on healthcare worldwide.
Leon eCaly, Reena eGhildyal, David Andrew Jans   +2 more
doaj   +1 more source

RBM20 phosphorylation and its role in nucleocytoplasmic transport and cardiac pathogenesis. [PDF]

FASEB J, 2022
Arginine-serine (RS) domain(s) in splicing factors are critical for protein-protein interaction in pre-mRNA splicing. Phosphorylation of RS domain is important for splicing control and nucleocytoplasmic transport in the cell. RNA-binding motif 20 (RBM20)
Zhang Y, Wang C, Sun M, Jin Y, Braz CU, Khatib H, Hacker TA, Liss M, Gotthardt M, Granzier H, Ge Y, Guo W.   +11 more
europepmc   +2 more sources

Role of molecular charge in nucleocytoplasmic transport. [PDF]

PLoS ONE, 2014
Transport of genetic materials and proteins between the nucleus and cytoplasm of eukaryotic cells is mediated by nuclear pore complexes (NPCs). A selective barrier formed by phenylalanine-glycine (FG) nucleoporins (Nups) with net positive charges in the ...
Alexander Goryaynov, Weidong Yang
doaj   +1 more source