Results 31 to 40 of about 12,509 (185)
Functional interactions between nucleoporins and chromatin [PDF]
Current Opinion in Cell Biology, 2011 As the gatekeepers of the eukaryotic cell nucleus, nuclear pore complexes (NPCs) mediate all molecular trafficking between the nucleoplasm and the cytoplasm. In recent years, transport-independent functions of NPC components, nucleoporins, have been identified including roles in chromatin organization and gene regulation. Here, we summarize our current
Yun, Liang, Martin W, Hetzer
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Cell Reports, 2015 CRM1 is the major nuclear export receptor. During translocation through the nuclear pore, transport complexes transiently interact with phenylalanine-glycine (FG) repeats of multiple nucleoporins. On the cytoplasmic side of the nuclear pore, CRM1 tightly
Sarah A. Port +7 more
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Importins/Karyopherins Meet Nucleoporins [PDF]
Cell, 1996 I thank Gunter Blobel, Valerie Doye, Dirk Gorlich, Iain Mattaj, Ulf Nehrbass, and Uli Scheer for helpful comments on the manuscript.
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eLife, 2015 Nuclear pore complexes (NPCs) conduct massive transport mediated by shuttling nuclear transport receptors (NTRs), while keeping nuclear and cytoplasmic contents separated.
Hermann Broder Schmidt, Dirk Görlich
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The human nucleoporin Tpr protects cells from RNA-mediated replication stress
Nature Communications, 2021 Tpr nucleoporin is known to be essential for nuclear transport and mitosis processes. Here the authors explore the link between Tpr and genome instability providing insights into the role of Tpr in safeguarding cells from RNA-mediated replication stress.
Martin Kosar +21 more
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eLife, 2022 The nuclear envelope (NE) assembles and grows from bilayer lipids produced at the endoplasmic reticulum (ER). How ER membrane incorporation coordinates with assembly of nuclear pore complexes (NPCs) to generate a functional NE is not well understood ...
Michael Sean Mauro +6 more
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Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2
eLife, 2018 HIV-1 accesses the nuclear DNA of interphase cells via a poorly defined process involving functional interactions between the capsid protein (CA) and nucleoporins (Nups).
Melissa Kane +6 more
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Case report: Compound heterozygous NUP85 variants cause autosomal recessive primary microcephaly
Frontiers in Neurology, 2023 Nucleoporin (NUP) 85 is a member of the Y-complex of nuclear pore complex (NPC) that is key for nucleocytoplasmic transport function, regulation of mitosis, transcription, and chromatin organization.
Ethiraj Ravindran +11 more
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Nucleoporin Nup98: a gatekeeper in the eukaryotic kingdoms [PDF]
Genes to Cells, 2010 The nucleoporin Nup98 is an essential component of the nuclear pore complex. This peripheral nucleoporin with its Gly‐Leu‐Phe‐Gly (GLFG) repeat domain contributes to nuclear‐cytoplasmic trafficking, including mRNA export. In addition, accumulating studies indicate that Nup98 plays roles in several important biological events such as gene expression ...
Masaaki, Iwamoto +3 more
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Disease Models & Mechanisms, 2022 Nucleoporin 98KD (Nup98) is a promiscuous translocation partner in hematological malignancies. Most disease models of Nup98 translocations involve ectopic expression of the fusion protein under study, leaving the endogenous Nup98 loci unperturbed ...
Ajai J. Pulianmackal +6 more
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