Results 31 to 40 of about 14,867 (213)

ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma

eLife, 2023
The nucleoporin (NUP) ELYS, encoded by AHCTF1, is a large multifunctional protein with essential roles in nuclear pore assembly and mitosis. Using both larval and adult zebrafish models of hepatocellular carcinoma (HCC), in which the expression of an ...
Kimberly J Morgan, Karen Doggett, Fansuo Geng, Stephen Mieruszynski, Lachlan Whitehead, Kelly A Smith, Benjamin M Hogan, Cas Simons, Gregory J Baillie, Ramyar Molania, Anthony T Papenfuss, Thomas E Hall, Elke A Ober, Didier YR Stainier, Zhiyuan Gong, Joan K Heath   +15 more
doaj   +1 more source

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention. [PDF]

Adv Mater
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Stefanello ST, Mizdal CR, da Silva AF, Qian Y, Yuan WE, Shahin V.   +5 more
europepmc   +2 more sources

Cohesiveness tunes assembly and morphology of FG nucleoporin domain meshworks – Implications for nuclear pore permeability [PDF]

, 2013
Nuclear pore complexes control the exchange of macromolecules between the cytoplasm and the nucleus. A selective permeability barrier that arises from a supramolecular assembly of intrinsically unfolded nucleoporin domains rich in phenylalanine-glycine ...
Frey, S., Frey, Steffen, Görlich, D., Eisele, N., Richter, R., Steffen Frey, Dirk Görlich, Richter , R., Labokha, A., Ralf P. Richter, Aksana A. Labokha, Görlich, Dirk, Nico B. Eisele, Goerlich, D., Labokha, Aksana a., Eisele, Nico b., Richter, Ralf p.   +16 more
core   +1 more source

Regulation of autophagy by nucleoporin Tpr [PDF]

Scientific Reports, 2012
The nuclear pore complex (NPC) consists of a conserved set of ~30 different proteins, termed nucleoporins, and serves as a gateway for the exchange of materials between the cytoplasm and nucleus. Tpr (translocated promoter region) is a component of NPC that presumably localizes at intranuclear filaments. Here, we show that Tpr knockdown caused a severe
Funasaka, Tatsuyoshi, Tsuka, Eriko, Wong, Richard W.   +2 more
openaire   +2 more sources

Redox-Sensitive Cysteines Confer Proximal Control of the Molecular Crowding Barrier in the Nuclear Pore

Cell Reports, 2020
Summary: The nuclear pore complex forms a highly crowded selective barrier with intrinsically disordered regions at the nuclear membrane to coordinate nucleocytoplasmic molecular communications.
Wanzhen Zhang, Ryuji Watanabe, Hide A. Konishi, Takahiro Fujiwara, Shige H. Yoshimura, Masahiro Kumeta   +5 more
doaj   +1 more source

NUP98 (nucleoporin 98 kDa) [PDF]

, 1998
Review on NUP98 (nucleoporin 98 kDa), with data on DNA, on the protein encoded, and where the gene is ...
Huret, JL, JL Huret
core   +1 more source

NUP98 (nucleoporin 98 kDa) [PDF]

, 2002
Review on NUP98 (nucleoporin 98 kDa), with data on DNA, on the protein encoded, and where the gene is ...
Kearney, L
core   +1 more source

Nucleoporin genes in human diseases [PDF]

European Journal of Human Genetics, 2016
Nuclear pore complexes (NPCs) are large channels spanning the nuclear envelope that mediate nucleocytoplasmic transport. They are composed of multiple copies of ~30 proteins termed nucleoporins (NUPs). Alterations in NUP genes are linked to several human neoplastic and non-neoplastic diseases.
NOFRINI, VALERIA, DI GIACOMO, DANIKA, MECUCCI, Cristina   +2 more
openaire   +2 more sources

Translocation Biosensors – Cellular System Integrators to Dissect CRM1-Dependent Nuclear Export by Chemicogenomics

Sensors, 2009
Fluorescent protein biosensors are powerful cellular systems biology tools for dissecting the complexity of cellular processes with high spatial and temporal resolution. As regulated nucleo-cytoplasmic transport is crucial for the modulation of numerous (
Roland H. Stauber, Shirley K. Knauer, Jens Peter von Kries, Carolin Bier, Verena Fetz   +4 more
doaj   +1 more source

Shaping the p53 Response with Nucleoporins [PDF]

Molecular Cell, 2012
In this issue, Singer et al. (2012) reveal that the nucleoporin Nup98 supports adaptation to genotoxic stress by protecting specific p53-induced mRNAs from exosome-dependent degradation, suggesting that wild-type Nup98 may possess tumor suppressor function.
Yarbrough, Melanie L., White, Michael A., Fontoura, Beatriz M.A.   +2 more
openaire   +2 more sources