Results 21 to 30 of about 14,867 (213)
Lipid Droplets Are a Physiological Nucleoporin Reservoir [PDF]
Cells, 2021 Lipid Droplets (LD) are dynamic organelles that originate in the Endoplasmic Reticulum and mostly bud off toward the cytoplasm, where they store neutral lipids for energy and protection purposes. LD also have diverse proteins on their surface, many of which are necessary for the their correct homeostasis.
Sylvain Kumanski +3 more
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Multifunctionality of F-rich nucleoporins [PDF]
Biochemical Society Transactions, 2020 Nucleoporins (Nups) represent a range of proteins most known for composing the macromolecular assembly of the nuclear pore complex (NPC). Among them, the family of intrinsically disordered proteins (IDPs) phenylalanine-glycine (FG) rich Nups, form the permeability barrier and coordinate the high-speed nucleocytoplasmic transport in a selective way ...
Nike Heinß +3 more
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The Nuclear Life of Nucleoporins [PDF]
Developmental Cell, 2007 Nucleoporins are the constituents of the nuclear pore complex, but they are also known to shuttle to the nuclear interior, the function of which is unclear. In a recent issue of Nature Cell Biology, Wang et al.'s mechanistic studies of leukemogenic fusion proteins that contain nucleoporins suggest that they have a direct role in transcription.
Kalverda, Bernike, Fornerod, Maarten
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Autoproteolysis in nucleoporin biogenesis [PDF]
Proceedings of the National Academy of Sciences, 1999 We have molecularly characterized a proteolytic cleavage in conserved nuclear pore complex proteins. This cleavage, previously demonstrated to be essential for the biogenesis of two nuclear pore complex proteins in mammals (Nup98 and Nup96) and yeast (Nup145-N and Nup145-C), occurs between Phe and Ser residues within a highly ...
J S, Rosenblum, G, Blobel
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The Nuclear Pore Complex: Birth, Life, and Death of a Cellular Behemoth
Cells, 2022 Nuclear pore complexes (NPCs) are the only transport channels that cross the nuclear envelope. Constructed from ~500–1000 nucleoporin proteins each, they are among the largest macromolecular assemblies in eukaryotic cells.
Elisa Dultz +3 more
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Nucleoporins in cardiovascular disease
Journal of Molecular and Cellular Cardiology, 2020 Cardiovascular disease is a pressing health problem with significant global health, societal, and financial burdens. Understanding the molecular basis of polygenic cardiac pathology is thus essential to devising novel approaches for management and treatment.
Ryan D, Burdine +4 more
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Role of Nucleoporins and Transport Receptors in Cell Differentiation
Frontiers in Physiology, 2020 Bidirectional molecular movements between the nucleus and cytoplasm take place through nuclear pore complexes (NPCs) embedded in the nuclear membrane.
Asmat Ullah Khan +3 more
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Nucleus, 2020 Xenopus egg extracts are a powerful in vitro tool for studying complex biological processes, including nuclear reconstitution, nuclear membrane and pore assembly, and spindle assembly.
Matthew S. Nord +5 more
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A mosaic of old and young nucleoporins [PDF]
Journal of Cell Biology, 2019 Some nucleoporins, the nuclear pore complex (NPC) components, have exceptionally long lifetimes. In this issue, Toyama et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201809123) report that NPCs are maintained by a slow piecemeal replacement of NPC components in dividing and terminally differentiated cells and by whole-pore exchange in ...
Takeshi Shimi, Hiroshi Kimura
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Involvement in surface antigen expression by a moonlighting FG-repeat nucleoporin in trypanosomes. [PDF]
, 2018 Components of the nuclear periphery coordinate a multitude of activities, including macromolecular transport, cell-cycle progression, and chromatin organization.
Field, Mark C +10 more
core +3 more sources