Results 21 to 30 of about 12,509 (185)
Frontiers in Oncology, 2017 In mammalian organisms liquid tumors such as acute myeloid leukemia (AML) are related to spontaneous chromosomal translocations ensuing in gene fusions.
Valentina Tosato +10 more
doaj +1 more source
The Nuclear Pore Complex: Birth, Life, and Death of a Cellular Behemoth
Cells, 2022 Nuclear pore complexes (NPCs) are the only transport channels that cross the nuclear envelope. Constructed from ~500–1000 nucleoporin proteins each, they are among the largest macromolecular assemblies in eukaryotic cells.
Elisa Dultz +3 more
doaj +1 more source
Nucleoporin genes in human diseases [PDF]
European Journal of Human Genetics, 2016 Nuclear pore complexes (NPCs) are large channels spanning the nuclear envelope that mediate nucleocytoplasmic transport. They are composed of multiple copies of ~30 proteins termed nucleoporins (NUPs). Alterations in NUP genes are linked to several human neoplastic and non-neoplastic diseases.
NOFRINI, VALERIA +2 more
openaire +2 more sources
Shaping the p53 Response with Nucleoporins [PDF]
Molecular Cell, 2012 In this issue, Singer et al. (2012) reveal that the nucleoporin Nup98 supports adaptation to genotoxic stress by protecting specific p53-induced mRNAs from exosome-dependent degradation, suggesting that wild-type Nup98 may possess tumor suppressor function.
Yarbrough, Melanie L. +2 more
openaire +2 more sources
The Human NUP58 Nucleoporin Can Form Amyloids In Vitro and In Vivo
Biomedicines, 2021 Amyloids are fibrillar protein aggregates with a cross-β structure and unusual features, including high resistance to detergent or protease treatment.
Lavrentii G. Danilov +6 more
doaj +1 more source
Nucleus, 2012 Transcriptional regulation is a complex process that requires the integrated action of many multi-protein complexes. The way in which a living cell coordinates the action of these complexes in time and space is still poorly understood. Recent work has shown that nuclear pores, well known for their role in 3' processing and export of transcripts, also ...
Sarma, Nayan J, Willis, Kristine
openaire +3 more sources
Viruses Challenge Selectivity Barrier of Nuclear Pores
Viruses, 2013 Exchange between the nucleus and the cytoplasm occurs through nuclear pore complexes (NPCs) embedded in the double membrane of the nuclear envelope. NPC permeability barrier restricts the entry of inert molecules larger than 5 nm in diameter but allows ...
Ariberto Fassati, Aksana A. Labokha
doaj +1 more source
Nuclear distributions of NUP62 and NUP214 suggest architectural diversity and spatial patterning among nuclear pore complexes. [PDF]
PLoS ONE, 2012 The shape of nuclei in many adherent cultured cells approximates an oblate ellipsoid, with contralateral flattened surfaces facing the culture plate or the medium.
Yayoi Kinoshita +3 more
doaj +1 more source
Communicative & Integrative Biology, 2018 The nuclear pore complex (NPC) is the sole gateway for molecular transport between the nucleus and the cytoplasm in eukaryotes. The NPC is composed of approximately 30 different kinds of protein components called nucleoporins. The functional structure of
Masaaki Iwamoto +2 more
doaj +1 more source
Frontiers in Plant Science, 2019 Plant cells enhance the tolerances to abiotic and biotic stresses via recognition of the stress, activation and nuclear import of signaling factors, up-regulation of defense genes, nuclear export of mRNA and translation of defense proteins.
Yuri Mizuno +10 more
doaj +1 more source