Results 41 to 50 of about 14,867 (213)
Frontiers in Oncology, 2017 In mammalian organisms liquid tumors such as acute myeloid leukemia (AML) are related to spontaneous chromosomal translocations ensuing in gene fusions.
Valentina Tosato +10 more
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Nucleus, 2012 Transcriptional regulation is a complex process that requires the integrated action of many multi-protein complexes. The way in which a living cell coordinates the action of these complexes in time and space is still poorly understood. Recent work has shown that nuclear pores, well known for their role in 3' processing and export of transcripts, also ...
Sarma, Nayan J, Willis, Kristine
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Nature Communications, 2020 The nuclear pore complex components, nucleoporins, have been proposed to mediate spatial and temporal organization of chromatin. Here, the authors show that Nucleoporin 153 interacts with CTCF and cohesin, and mediates their binding across cis-regulatory
Shinichi Kadota +5 more
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Proximity‐Induced Protein Deglycosylation by Endogenous O‐GlcNAcase
Angewandte Chemie, EarlyView.Bifunctional molecules recruit endogenous O‑GlcNAcase to target proteins, enabling selective de‑O‑GlcNAcylation in living cells without perturbing global O‑GlcNAc homeostasis. This work developed a programmable chemical strategy for targeted O‑GlcNAc editing and framework for functional enzymatic recruitment via optimization of competitive enzyme ...
Haixing Xu +4 more
wiley +2 more sources
Viruses Challenge Selectivity Barrier of Nuclear Pores
Viruses, 2013 Exchange between the nucleus and the cytoplasm occurs through nuclear pore complexes (NPCs) embedded in the double membrane of the nuclear envelope. NPC permeability barrier restricts the entry of inert molecules larger than 5 nm in diameter but allows ...
Ariberto Fassati, Aksana A. Labokha
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Frontiers in Plant Science, 2019 Plant cells enhance the tolerances to abiotic and biotic stresses via recognition of the stress, activation and nuclear import of signaling factors, up-regulation of defense genes, nuclear export of mRNA and translation of defense proteins.
Yuri Mizuno +10 more
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Nuclear distributions of NUP62 and NUP214 suggest architectural diversity and spatial patterning among nuclear pore complexes. [PDF]
PLoS ONE, 2012 The shape of nuclei in many adherent cultured cells approximates an oblate ellipsoid, with contralateral flattened surfaces facing the culture plate or the medium.
Yayoi Kinoshita +3 more
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Functional interactions between nucleoporins and chromatin [PDF]
Current Opinion in Cell Biology, 2011 As the gatekeepers of the eukaryotic cell nucleus, nuclear pore complexes (NPCs) mediate all molecular trafficking between the nucleoplasm and the cytoplasm. In recent years, transport-independent functions of NPC components, nucleoporins, have been identified including roles in chromatin organization and gene regulation. Here, we summarize our current
Yun, Liang, Martin W, Hetzer
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Importins/Karyopherins Meet Nucleoporins [PDF]
Cell, 1996 I thank Gunter Blobel, Valerie Doye, Dirk Gorlich, Iain Mattaj, Ulf Nehrbass, and Uli Scheer for helpful comments on the manuscript.
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Functional polymorphism within NUP210 encoding for nucleoporin GP210 is associated with the risk of endometriosis [PDF]
, 2019 Objective: To investigate whether nucleoporin 210 (GP210, encoded by NUP210 gene) is involved in endometriosis. Design: Immunohistofluorescence analysis for assessing whether GP210 is expressed in endometrial tissues from patients and controls ...
Luisi S. +38 more
core +2 more sources