Results 41 to 50 of about 19,822 (225)
Communicative & Integrative Biology, 2018 The nuclear pore complex (NPC) is the sole gateway for molecular transport between the nucleus and the cytoplasm in eukaryotes. The NPC is composed of approximately 30 different kinds of protein components called nucleoporins. The functional structure of
Masaaki Iwamoto +2 more
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A novel function for the Caenorhabditis elegans torsin OOC-5 in nucleoporin localization and nuclear import. [PDF]
, 2015 Torsin proteins are AAA+ ATPases that localize to the endoplasmic reticular/nuclear envelope (ER/NE) lumen. A mutation that markedly impairs torsinA function causes the CNS disorder DYT1 dystonia. Abnormalities of NE membranes have been linked to torsinA
Dauer, William T +4 more
core +2 more sources
Frontiers in Plant Science, 2019 Plant cells enhance the tolerances to abiotic and biotic stresses via recognition of the stress, activation and nuclear import of signaling factors, up-regulation of defense genes, nuclear export of mRNA and translation of defense proteins.
Yuri Mizuno +10 more
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Toward the atomic structure of the nuclear pore complex: when top down meets bottom up [PDF]
, 2016 Elucidating the structure of the nuclear pore complex (NPC) is a prerequisite for understanding the molecular mechanism of nucleocytoplasmic transport.
Beck, Martina +2 more
core +1 more source
Regulation of autophagy by nucleoporin Tpr [PDF]
Scientific Reports, 2012 The nuclear pore complex (NPC) consists of a conserved set of ~30 different proteins, termed nucleoporins, and serves as a gateway for the exchange of materials between the cytoplasm and nucleus. Tpr (translocated promoter region) is a component of NPC that presumably localizes at intranuclear filaments. Here, we show that Tpr knockdown caused a severe
Funasaka, Tatsuyoshi +2 more
openaire +2 more sources
Cell Reports, 2015 CRM1 is the major nuclear export receptor. During translocation through the nuclear pore, transport complexes transiently interact with phenylalanine-glycine (FG) repeats of multiple nucleoporins. On the cytoplasmic side of the nuclear pore, CRM1 tightly
Sarah A. Port +7 more
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Role of the aryl hydrocarbon receptor in Sugen 5416-induced experimental pulmonary hypertension [PDF]
, 2018 Rationale: Rats dosed with the vascular endothelial growth factor (VEGF) inhibitor Sugen 5416 (Su), placed in hypoxia then restored to normoxia has become a widely used model of pulmonary arterial hypertension (PAH).
Dean, Afshan +6 more
core +1 more source
Linking Nucleoporins, Mitosis, and Colon Cancer [PDF]
Cell Chemical Biology, 2016 Suppression of a nuclear pore protein Nup358/RanBP2 is linked to mitotic cell death, but the clinical relevance of this link is unknown. In a recent issue of Cell, Vecchione et al. (2016) show that in approximately 10% of BRAF-like colorectal cancer (CC) patients, Nup358/RanBP2 is critical for survival.
Richard W, Wong, Maximiliano, D'Angelo
openaire +2 more sources
eLife, 2015 Nuclear pore complexes (NPCs) conduct massive transport mediated by shuttling nuclear transport receptors (NTRs), while keeping nuclear and cytoplasmic contents separated.
Hermann Broder Schmidt, Dirk Görlich
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The human nucleoporin Tpr protects cells from RNA-mediated replication stress
Nature Communications, 2021 Tpr nucleoporin is known to be essential for nuclear transport and mitosis processes. Here the authors explore the link between Tpr and genome instability providing insights into the role of Tpr in safeguarding cells from RNA-mediated replication stress.
Martin Kosar +21 more
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