Results 61 to 70 of about 19,822 (225)

Nuclear Import of Hepatitis B Virus Capsids and Genome

Viruses, 2017
Hepatitis B virus (HBV) is an enveloped pararetrovirus with a DNA genome, which is found in an up to 36 nm-measuring capsid. Replication of the genome occurs via an RNA intermediate, which is synthesized in the nucleus.
Lara Gallucci, Michael Kann
doaj   +1 more source

Simple biophysics underpins collective conformations of the intrinsically disordered proteins of the Nuclear Pore Complex [PDF]

, 2016
Nuclear Pore Complexes (NPCs) are key cellular transporter that control nucleocytoplasmic transport in eukaryotic cells, but its transport mechanism is still not understood.
Coalson, Rob D., Gu, Chad, Jasnow, David, Kapinos, Larisa E., Lim, Roderick Y. H., Opferman, Michael G., Vovk, Andrei, Zilman, Anton   +7 more
core   +1 more source

Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells

eLife, 2019
We previously demonstrated that CRM1, a major nuclear export factor, accumulates at Hox cluster regions to recruit nucleoporin-fusion protein Nup98HoxA9, resulting in robust activation of Hox genes (Oka et al., 2016).
Masahiro Oka, Sonoko Mura, Mayumi Otani, Yoichi Miyamoto, Jumpei Nogami, Kazumitsu Maehara, Akihito Harada, Taro Tachibana, Yoshihiro Yoneda, Yasuyuki Ohkawa   +9 more
doaj   +1 more source

SCARB1 downregulation in adrenal insufficiency with Allgrove syndrome

Orphanet Journal of Rare Diseases, 2023
Background Allgrove disease is a rare genetic syndrome characterized by adrenal insufficiency, alacrimia, achalasia and complex neurological involvement.
Giacomo Bitetto, Gianluca Lopez, Dario Ronchi, Alessandra Pittaro, Valentina Melzi, Erika Peverelli, Fulvia Milena Cribiù, Giacomo P. Comi, Giovanna Mantovani, Alessio Di Fonzo   +9 more
doaj   +1 more source

Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis [PDF]

, 2016
Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage.
Toofan, Parto, Wheadon, Helen
core   +1 more source

Importins/Karyopherins Meet Nucleoporins [PDF]

Cell, 1996
I thank Gunter Blobel, Valerie Doye, Dirk Gorlich, Iain Mattaj, Ulf Nehrbass, and Uli Scheer for helpful comments on the manuscript.
openaire   +1 more source

Nuclear Pore Proteins in Regulation of Chromatin State

Cells, 2019
Nuclear pore complexes (NPCs) are canonically known to regulate nucleocytoplasmic transport. However, research efforts over the last decade have demonstrated that NPCs and their constituent nucleoporins (Nups) also interact with the genome and perform ...
Terra M. Kuhn, Maya Capelson
doaj   +1 more source

Meiotic cellular rejuvenation is coupled to nuclear remodeling in budding yeast. [PDF]

, 2019
Production of healthy gametes in meiosis relies on the quality control and proper distribution of both nuclear and cytoplasmic contents. Meiotic differentiation naturally eliminates age-induced cellular damage by an unknown mechanism.
Chetlapalli, Keerthana, Goodman, Jay S, Jorgens, Danielle M, King, Grant A, McDonald, Kent L, Schick, Jennifer G, Ünal, Elçin   +6 more
core   +1 more source

Involvement in surface antigen expression by a moonlighting FG-repeat nucleoporin in trypanosomes [PDF]

, 2018
Components of the nuclear periphery coordinate a multitude of activities, including macromolecular transport, cell-cycle progression, and chromatin organization.
Acosta-Serrano A, Ahmed S, Akiyoshi B, Alexander V. Ratushny, Alsford S, Alsford S, Anne Spang, Bapteste E, Barth S, Bastin P, Brian T. Chait, Brun R, Budhraja V, Capelson M, Capitanio JS, Casolari JM, Chikne V, Clayton CE, Cronshaw JM, Daniels JP, Das A, deGrasse JA, Dieppois G, Dilworth DJ, duBois KN, Engstler M, Finn RD, Galy V, Galy V, Gravely BR, Guindon S, Gupta SK, Hirumi H, Ibarra A, Iouk T, Ishii K, Ismaïli N, Ismaïli N, Jean-Mathieu Bart, Jennifer M. Holden, John D. Aitchison, Kalverda B, Kasper LH, Katoh K, Kelly S, Kolev NG, Kramer S, Krull S, Kurshakova MM, Landeira D, Li H, Liang XH, Liang Y, Light WH, Ludek Koreny, Manger ID, Mark C. Field, Menon BB, Michael P. Rout, Miguel Navarro, Morchoisne-Bolhy S, Navarro M, Neumann N, Obado S, Oberholzer M, Ouellette M, Palenchar JB, Park JH, Rasband WS, Rout MP, Samson Obado, Schindelin J, Schwede A, Schwede A, Stanne TM, Tous C, Trapnell C, Utter CJ, Vaquerizas JM, Vassella E, Wei-Ming Chen, Wirtz E, Xu H, Yang X   +83 more
core   +2 more sources

Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants

Advanced Science, EarlyView.
The diversity of plant condensates reflects constraints of sessile organisms to coordinate postembryonic development with environmental adaptation. This review examines how plants employ condensates to integrate temperature, light, redox, and nutrient signals.
Panagiotis N. Moschou, Dorothee Staiger
wiley   +1 more source