Results 61 to 70 of about 12,509 (185)

Identification of Yeast Protein Sequences With Similarity to the ESCRT‐III Protein Snf7

Yeast, EarlyView.
ABSTRACT Endosomal sorting complex required for transport (ESCRT‐III) is a membrane remodeling complex involved in a large number of cellular processes. It appears to perform an essential function in eukaryotes, since to date no eukaryotic organism completely devoid of ESCRT‐III has been found.
Thomas Brune, Ralf Kölling
wiley   +1 more source

Nucleoporin Nup62 maintains centrosome homeostasis [PDF]

Cell Cycle, 2013
Centrosomes are comprised of 2 orthogonally arranged centrioles surrounded by the pericentriolar material (PCM), which serves as the main microtubule organizing center of the animal cell. More importantly, centrosomes also control spindle polarity and orientation during mitosis.
Hashizume, Chieko, Moyori, Akane, Kobayashi, Akiko, Yamakoshi, Nana, Endo, Aoi, Wong, Richard W   +5 more
openaire   +2 more sources

Loss of Nup210 results in muscle repair delays and age-associated alterations in muscle integrity

Life Science Alliance, 2022
This study describes the  the role of a nuclear pore complex protein in mammalian in skeletal muscle maintenance, repair, and function. Nuclear pore complexes, the channels connecting the nucleus with the cytoplasm, are built by multiple copies of ∼30 ...
Stephen Sakuma, Ethan YS Zhu, Marcela Raices, Pan Zhang, Rabi Murad, Maximiliano A D’Angelo   +5 more
doaj   +1 more source

Elucidating the Role of SET as a Key Contributor to Neurodevelopmental Disability Within the 9q34.11 Deletion Syndrome Interval

Clinical Genetics, EarlyView.
This study reports a female proband with a de novo 9q34.11 deletion affecting SET, who underwent a 28‐year diagnostic odyssey after an atypical Rett syndrome clinical diagnosis. Genomic and proteomics analyses confirmed SET haploinsufficiency, refining the critical 9q34.11 region, and supporting speech therapy benefits in improving meaningful ...
Angelo Condell, Elaine Zhang, Tim Sikora, Sean Massey, Nicole J. Van Bergen, Min Wang, Cas Simons, Katrina M. Bell, Daniella H. Hock, David A. Stroud, David Francis, Wendy A. Gold, Martin B. Delatycki, John Christodoulou, Simranpreet Kaur   +14 more
wiley   +1 more source

Genetic Determinants of Treatment‐Related Bone Toxicity in Pediatric Acute Lymphoblastic Leukemia

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 786-794, September 2026.
Osteonecrosis and fractures are serious corticosteroid‐induced bone toxicities in children treated for acute lymphoblastic leukemia, yet their genetic determinants remain incompletely defined. In this study, we aimed to identify novel genetic contributors to bone toxicity and to evaluate the robustness of both newly identified and previously ...
Rachid Abaji, Vincent Gagné, Émilie Espagne, Nathalie Alos, Veronica Del Vecchio, Lamia Ait Said, Albert Shalmiev, Claire Fuchs, Caroline Laverdière, Jean‐Marie Leclerc, Stephen E. Sallan, Lewis B. Silverman, Daniel Sinnett, Thai Hoa Tran, Maja Krajinovic   +14 more
wiley   +1 more source

Nuclear membrane disruption in neurodegenerative diseases: Emerging perspectives

Neural Regeneration Research
The nucleus, as the largest organelle within the cell, serves as the central hub for storing, replicating, and transcribing genetic information, thereby orchestrating vital cellular processes.
Shuo Yuan, Nicholas Essepian, Qingbo Wang, Lulu Jiang   +3 more
doaj   +1 more source

Cell type‐specific nuclear pores: a case in point for context‐dependent stoichiometry of molecular machines

Molecular Systems Biology, 2013
To understand the structure and function of large molecular machines, accurate knowledge of their stoichiometry is essential. In this study, we developed an integrated targeted proteomics and super‐resolution microscopy approach to determine the absolute
Alessandro Ori, Niccolò Banterle, Murat Iskar, Amparo Andrés‐Pons, Claudia Escher, Huy Khanh Bui, Lenore Sparks, Victor Solis‐Mezarino, Oliver Rinner, Peer Bork, Edward A Lemke, Martin Beck   +11 more
doaj   +1 more source

Disclosing the Interactome of Leukemogenic NUP98-HOXA9 and SET-NUP214 Fusion Proteins Using a Proteomic Approach

Cells, 2020
The interaction of oncogenes with cellular proteins is a major determinant of cellular transformation. The NUP98-HOXA9 and SET-NUP214 chimeras result from recurrent chromosomal translocations in acute leukemia.
Adélia Mendes, Ramona Jühlen, Sabrina Bousbata, Birthe Fahrenkrog   +3 more
doaj   +1 more source

Nucleoporin 98 Rearrangements in Acute Leukemia: A Genomic Landscape Study

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT Nucleoporin 98 rearrangements (NUP98re) occur in a wide range of hematologic malignancies including acute leukemias with a variety of fusion partners. NUP98re is associated with adverse prognosis, especially in children. We aimed to better understand the genomics of acute leukemias with NUP98re including fusion partners and co‐occurring ...
Osama Batayneh, Natalie Danziger, Mahmoudreza Moein, Nour S. Naji, Dean Pavlick, Jeffrey S. Ross, Chelsea Marcus, Caleb Ho, Teresa Gentile, Zheng Zhou, Lincoln W. Pasquina   +10 more
wiley   +1 more source

Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism

Cell Proliferation, Volume 59, Issue 8, August 2026.
Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang, Yuan‐Tao Qiu, Jing‐Yue Cao, Yi‐Feng Huang, Ye‐Lin Lan, Yu‐Li Zhao, Fu Wu, Chen‐Long Wang, Guo‐Run Tang, Jing‐Yun Ji, Zhang Zhang, Guan‐Zheng Luo   +11 more
wiley   +1 more source