Results 71 to 80 of about 19,822 (225)

Functional study of a novel missense single-nucleotide variant of NUP107 in two daughters of Mexican origin with premature ovarian insufficiency. [PDF]

, 2018
BackgroundHypergonadotropic hypogonadism (HH) is a genetically heterogeneous disorder that usually presents with amenorrhea, atrophic ovaries, and low estrogen. Most cases of HH are idiopathic and nonsyndromic.
Diao, Feiyang, Jiang, Huaiyang, Katari, Sunita, Rajkovic, Aleksandar, Ren, Yu, Wood-Trageser, Michelle A, Yatsenko, Svetlana   +6 more
core   +2 more sources

Rae1: A new clue for nucleoporin leukemias [PDF]

Cell Cycle, 2011
N/A ; © 2011 Landes Bioscience.
Stuwe, Tobias, Hoelz, André
openaire   +3 more sources

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine

Advanced Science, EarlyView.
Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han   +15 more
wiley   +1 more source

NUP98 (nucleoporin 98 kDa) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on NUP98 (nucleoporin 98 kDa), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +1 more source

RNA nuclear export is blocked by poliovirus 2A protease and is concomitant with nucleoporin cleavage [PDF]

, 2009
Cytopathic viruses have developed successful strategies to block or, at least, to attenuate host interference with their replication. Here, we have analyzed the effects of poliovirus 2A protease on RNA nuclear export.
Carrasco Llamas, Luis, Castelló, Alfredo, Izquierdo, José M., Welnowska, Ewelina   +3 more
core   +1 more source

Nuclear pore dysfunction and disease: a complex opportunity

Nucleus
The separation of genetic material from bulk cytoplasm has enabled the evolution of increasingly complex organisms, allowing for the development of sophisticated forms of life. However, this complexity has created new categories of dysfunction, including
Charlotte M. Fare, Jeffrey D. Rothstein
doaj   +1 more source

Evidence for an evolutionary relationship between the large adaptor nucleoporin Nup192 and karyopherins [PDF]

, 2014
Nucleocytoplasmic transport is facilitated by nuclear pore complexes (NPCs), which are massive proteinaceous transport channels embedded in the nuclear envelope.
Collins, Leslie N., Hoelz, André, Hurt, Ed, Lin, Daniel H., Stuwe, Tobias   +4 more
core   +1 more source

Amyloid-like interactions within nucleoporin FG hydrogels [PDF]

Proceedings of the National Academy of Sciences, 2010
The 62 kDa FG repeat domain of the nucleoporin Nsp1p forms a hydrogel-based, sieve-like permeability barrier that excludes inert macromolecules but allows rapid entry of nuclear transport receptors (NTRs). We found that the N-terminal part of this domain, which is characterized by Asn-rich inter-FG spacers, forms a tough hydrogel.
Ader, C., Frey, S., Maas, W., Schmidt, H. B., Görlich, D., Baldus, M.   +5 more
openaire   +4 more sources

Adversarial Erasing Enhanced Multiple Instance Learning (siMILe): Discriminative Identification of Oligomeric Protein Structures in Single Molecule Localization Microscopy

Advanced Intelligent Systems, EarlyView.
Hallgrimson et al. introduce a machine learning algorithm, siMILe, that takes features of single‐molecule localization microscopy localization clusters (e.g., size and sphericity) and finds the clusters that are associated with certain cell conditions (such as differential protein expression or drug treatment).
Christian Hallgrimson, Y. Lydia Li, Claire A. Shou, Ben Cardoen, John Lim, Timothy H. Wong, Ismail M. Khater, Ivan Robert Nabi, Ghassan Hamarneh   +8 more
wiley   +1 more source

Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding

Nature Communications, 2020
The nuclear pore complex components, nucleoporins, have been proposed to mediate spatial and temporal organization of chromatin. Here, the authors show that Nucleoporin 153 interacts with CTCF and cohesin, and mediates their binding across cis-regulatory
Shinichi Kadota, Jianhong Ou, Yuming Shi, Jeannie T. Lee, Jiayu Sun, Eda Yildirim   +5 more
doaj   +1 more source