Results 81 to 90 of about 12,509 (185)

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis

Nature Communications, 2016
As signalling molecules, bile acids (BAs) can affect metabolism, but due to detergent-like properties, BA levels must be tightly regulated. Here, Kim et al.show that RanBP2, a nucleoporin, maintains BA homoeostasis through SUMOylation of Small ...
Dong-Hyun Kim, Sanghoon Kwon, Sangwon Byun, Zhen Xiao, Sean Park, Shwu-Yuan Wu, Cheng-Ming Chiang, Byron Kemper, Jongsook Kim Kemper   +8 more
doaj   +1 more source

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han   +15 more
wiley   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, Volume 13, Issue 40, 17 July 2026.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

Adversarial Erasing Enhanced Multiple Instance Learning (siMILe): Discriminative Identification of Oligomeric Protein Structures in Single Molecule Localization Microscopy

Advanced Intelligent Systems, Volume 8, Issue 7, July 2026.
Hallgrimson et al. introduce a machine learning algorithm, siMILe, that takes features of single‐molecule localization microscopy localization clusters (e.g., size and sphericity) and finds the clusters that are associated with certain cell conditions (such as differential protein expression or drug treatment).
Christian Hallgrimson, Y. Lydia Li, Claire A. Shou, Ben Cardoen, John Lim, Timothy H. Wong, Ismail M. Khater, Ivan Robert Nabi, Ghassan Hamarneh   +8 more
wiley   +1 more source

Nuclear dysfunction in aging and neurodegeneration

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract Neurodegenerative diseases are characterized by a loss of neuronal function and structure, often in a region‐specific manner. Multiple factors contribute to neuronal dysfunction and death, including pathogenic protein buildup, protein mislocalization, and inflammation. Despite extensive research, the common mechanisms driving neurodegeneration
Abbigael Aday, Jack Tiller, Adarsh Melukote, Zachary C. Walton, Anna King, Luke Castillo, Rakez Kayed, Mauro Montalbano   +7 more
wiley   +1 more source

The nucleoporin Nup88 is interacting with nuclear lamin A

Molecular Biology of the Cell, 2011
Nuclear pore complexes (NPCs) are embedded in the nuclear envelope (NE) and mediate bidirectional nucleocytoplasmic transport. Their spatial distribution in the NE is organized by the nuclear lamina, a meshwork of nuclear intermediate filament proteins. Major constituents of the nuclear lamina are A- and B-type lamins.
Lussi, Yvonne Y.C., Hügi, Ilona, Fahrenkrog, Birthe, Laurell, Eva Laurell E., Kutay, Ulrike   +4 more
openaire   +6 more sources

Secretion of Extracellular Vesicles Into the Mesenteric Lymph During Fasting and Lipid Absorption

Journal of Extracellular Biology, Volume 5, Issue 7, July 2026.
ABSTRACT The intestine plays critical roles in nutrient homeostasis and systemic health. The small intestine is the major organ that packages dietary lipids into chylomicrons and secretes them into the mesenteric lymph. Extracellular vesicles (EVs) as a mechanism for cell‐to‐cell communication often exhibit organ specific characteristics.
Tianyu Hang, Rita Wang, Kundanika Mukherjee, Uday Sandhu, Fengxia Xiao, Dylan Burger, Changting Xiao   +6 more
wiley   +1 more source

Compensation for chronic oxidative stress in ALADIN null mice

Biology Open, 2018
Mutations in the AAAS gene coding for the nuclear pore complex protein ALADIN lead to the autosomal recessive disorder triple A syndrome. Triple A patients present with a characteristic phenotype including alacrima, achalasia and adrenal insufficiency ...
Ramona Jühlen, Mirko Peitzsch, Sebastian Gärtner, Dana Landgraf, Graeme Eisenhofer, Angela Huebner, Katrin Koehler   +6 more
doaj   +1 more source

Triple A patient cells suffering from mitotic defects fail to localize PGRMC1 to mitotic kinetochore fibers

Cell Division, 2018
Background Membrane-associated progesterone receptors are restricted to the endoplasmic reticulum and are shown to regulate the activity of cytochrome P450 enzymes which are involved in steroidogenesis or drug detoxification.
Ramona Jühlen, Dana Landgraf, Angela Huebner, Katrin Koehler   +3 more
doaj   +1 more source

Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes

eLife, 2016
The nucleoporin Nup98 is frequently rearranged to form leukemogenic Nup98-fusion proteins with various partners. However, their function remains largely elusive. Here, we show that Nup98-HoxA9, a fusion between Nup98 and the homeobox transcription factor
Masahiro Oka, Sonoko Mura, Kohji Yamada, Percival Sangel, Saki Hirata, Kazumitsu Maehara, Koichi Kawakami, Taro Tachibana, Yasuyuki Ohkawa, Hiroshi Kimura, Yoshihiro Yoneda   +10 more
doaj   +1 more source