Results 91 to 100 of about 19,822 (225)
Evolution: functional evolution of nuclear structure. [PDF]
, 2011 The evolution of the nucleus, the defining feature of eukaryotic cells, was long shrouded in speculation and mystery. There is now strong evidence that nuclear pore complexes (NPCs) and nuclear membranes coevolved with the endomembrane system, and that ...
Dawson, Scott C, Wilson, Katherine L
core
Loss of angiotensin II receptor expression in dopamine neurons in Parkinson’s disease correlates with pathological progression and is accompanied by increases in Nox4- and 8-OH guanosine-related nucleic acid oxidation and caspase-3 activation [PDF]
, 2015 In rodent models of Parkinsons disease (PD), dopamine neuron loss is accompanied by increased expression of angiotensin II (AngII), its type 1 receptor (AT1), and NADPH oxidase (Nox) in the nigral dopamine neurons and microglia.
Aboud, O +6 more
core +2 more sources
Nucleoporin Gene Fusions and Hematopoietic Malignancies [PDF]
New Journal of Science, 2014 Nuclear pore complexes (NPCs) are the sole gateways between the nucleus and the cytoplasm of eukaryotic cells and they mediate all macromolecular trafficking between these cellular compartments. Nucleocytoplasmic transport is highly selective and precisely regulated and as such an important aspect of normal cellular function. Defects in this process or
openaire +2 more sources
The FASEB Journal, Volume 40, Issue 9, 15 May 2026.Cell wall stress in yeast triggers transcriptional reprogramming through the CWI pathway. This study identifies Sus1, a subunit of SAGA and TREX‐2, as a key regulator in this process. Sus1 associates with stress‐responsive genes, promoting pre‐initiation complex assembly, chromatin remodeling, and RNA Pol II progression independently of H2B ...
Mónica Pavón‐Vergés +4 more
wiley +1 more source
Molecular Systems Biology, 2013 To understand the structure and function of large molecular machines, accurate knowledge of their stoichiometry is essential. In this study, we developed an integrated targeted proteomics and super‐resolution microscopy approach to determine the absolute
Alessandro Ori +11 more
doaj +1 more source
Cells, 2020 The interaction of oncogenes with cellular proteins is a major determinant of cellular transformation. The NUP98-HOXA9 and SET-NUP214 chimeras result from recurrent chromosomal translocations in acute leukemia.
Adélia Mendes +3 more
doaj +1 more source
Gene gating at nuclear pores prevents the formation of R loops [PDF]
, 2017 Transcription is an important source of genetic variability. A large amount of transcription-associated genome variation arises from the unscheduled formation of R loops.
Aguilera López, Andrés +2 more
core +1 more source
Intercompartmental communication in senescence
FEBS Open Bio, Volume 16, Issue 5, Page 837-856, May 2026.Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz +3 more
wiley +1 more source
The Nuclear Pore Complex as a Flexible and Dynamic Gate [PDF]
, 2018 Nuclear pore complexes (NPCs) perforate the nuclear envelope and serve as the primary transport gates for molecular exchange between nucleus and cytoplasm.
Knockenhauer, Kevin Edward +1 more
core +1 more source
Advanced Science, Volume 13, Issue 25, 4 May 2026.Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song +4 more
wiley +1 more source