Results 91 to 100 of about 14,867 (213)
Nucleoporin Gene Fusions and Hematopoietic Malignancies [PDF]
New Journal of Science, 2014 Nuclear pore complexes (NPCs) are the sole gateways between the nucleus and the cytoplasm of eukaryotic cells and they mediate all macromolecular trafficking between these cellular compartments. Nucleocytoplasmic transport is highly selective and precisely regulated and as such an important aspect of normal cellular function. Defects in this process or
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Cancer Science, Volume 117, Issue 11, Page 3108-3120, November 2026.ABSTRACT Quizartinib is a FMS‐like tyrosine kinase 3 (FLT3) inhibitor indicated for FLT3 internal tandem duplication (FLT3‐ITD)–positive acute myeloid leukemia (AML). We aimed to evaluate quizartinib resistance mechanisms, in addition to efficacy and safety outcomes, in patients with relapsed or refractory FLT3‐ITD–positive AML.
Yuichiro Semba +21 more
wiley +1 more source
Nucleoporin 85 is Crucial for Nuclear Import of HIV-1
, 2007 Because HIV and other lentiviruses can uniquely stably replicate within non-dividing cells, we hypothesized that lentiviruses must utilize a special mechanism allowing them to interact with host cell nuclear pore complexes, thus granting the HIV pre ...
Gaudette, James
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The Plant Journal, Volume 128, Issue 3, November 2026.SUMMARY Importin α family proteins serve as essential carriers for transporting specific disease‐resistant proteins into the nucleus, enabling these proteins to function properly. However, whether importin α proteins are involved in plant immunity remains unclear.
Ting Zhang +10 more
wiley +1 more source
Advanced Science, Volume 13, Issue 55, 5 October 2026.Single‐cell transcriptomics of soybean roots soon after rhizobial inoculation reveals epidermal and cortical cell‐specific programs and gene‐regulatory networks acting in symbiosis establishment. We identify an ethylene‐driven regulatory circuit involving WRKY6.3/6.4 transcription factors targeting select Nod19 genes that promotes infection‐thread ...
Yongbin Zhuang +17 more
wiley +1 more source
Spatial control of nucleoporin condensation by fragile X‐related proteins [PDF]
, 2020 Nucleoporins (Nups) build highly organized nuclear pore complexes (NPCs) at the nuclear envelope (NE). Several Nups assemble into a sieve-like hydrogel within the central channel of the NPCs.
Schmucker, S. +62 more
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The nucleoporin Nup88 is interacting with nuclear lamin A
Molecular Biology of the Cell, 2011 Nuclear pore complexes (NPCs) are embedded in the nuclear envelope (NE) and mediate bidirectional nucleocytoplasmic transport. Their spatial distribution in the NE is organized by the nuclear lamina, a meshwork of nuclear intermediate filament proteins. Major constituents of the nuclear lamina are A- and B-type lamins.
Lussi, Yvonne Y.C. +4 more
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A Unifying Thermodynamic Model for Phase Separation and Aging of Biopolymers
Advanced Science, Volume 13, Issue 57, 14 October 2026.Phase separation and aging of intrinsically disordered proteins are placed in a unifying framework. A thermodynamically consistent time‐dependent version of associating‐polymer theory shows how the processes are intricately coupled. Assuming aging to occur through interacting sites resulting from reversible conformational transitions, the model ...
Jasper J. Michels +2 more
wiley +1 more source
Directed yeast two-hybrid assay reveals NUP-NPHP interactions.
, 2019 The indicated transition zone proteins (INV, NPHP1/4, NPHP5/6, MKS complexes) and nucleoporin proteins were fused to a DNA binding domain (BD) or transcription activation domain (AD).
Daisuke Takao (115457) +2 more
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A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy
, 2016 A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle ...
Lisa A Miosge (18608710) +9 more
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