Results 111 to 120 of about 19,822 (225)

PICALM::MLLT10 translocated leukemia

FEBS Letters, Volume 600, Issue 7, Page 1028-1042, April 2026.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Identification of a Novel, Oncogenic and Targetable TPR::ABL2 Fusion Gene in T‐Cell Acute Lymphoblastic Leukaemia

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT ABL2 rearrangements represent a subtype of acute lymphoblastic leukaemia (ALL) associated with poor prognosis and survival. This study reports a high‐risk T‐cell ALL (T‐ALL) case with a novel TPR::ABL2 gene fusion resulting from a chromosomal deletion.
Elias Lagonik, Elyse. C. Page, Laura N. Eadie, Caitlin E. Schutz, Jacqueline A. Rehn, Susan L. Heatley, Andrew S. Moore, Muirin Healy, Morag Whyte, Timothy P. Hughes, David T. Yeung, Deborah L. White   +11 more
wiley   +1 more source

Current perspectives on KMT2A fusion proteins and menin inhibition in paediatric acute myeloid leukaemia

The FEBS Journal, Volume 293, Issue 8, Page 2159-2177, April 2026.
Genetic rearrangements resulting in the expression of KMT2A fusion alleles can lead to dramatic transcriptional disturbances that contribute to the onset of acute leukaemias. Fortunately, menin inhibition has emerged as a promising new class of targeted therapy.
Lydia Elaine Roets, Graeme Greenfield, Katrina Mairead Lappin   +2 more
wiley   +1 more source

A comparison between nuclear dismantling during plant and animal programmed cell death [PDF]

, 2012
Programmed cell death (PCD) is a process of organized destruction of cells, essential for the development and maintenance of cellular homeostasis of multicellular organisms.
Cejudo Fernández, Francisco Javier, Domínguez del Toro, Fernando   +1 more
core   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors [PDF]

, 2013
Nucleocytoplasmic transport is mediated by nuclear pore complexes (NPCs) embedded in the nuclear envelope. About 30 different proteins (nucleoporins, nups) arrange around a central eightfold rotational axis to build the modular NPC. Nup188 and Nup192 are
Adam, Adams, Aitchison, Alber, Allen, Amlacher, Aravind, Bailer, Bayliss, Bayliss, Bednenko, Berka, Berke, Bilokapic, Brohawn, Brohawn, Brohawn, Capelson, Chook, Conti, Cook, Cronshaw, Devos, Dultz, D’Angelo, Emsley, Finlay, Flemming, Floer, Grandi, Grossman, Görlich, Hedges, Holm, Hülsmann, Jeudy, Kampmann, Leksa, Levy, Li, Lowe, Lutzmann, Mans, Marelli, McCoy, Menendez-Benito, Mohr, Nachury, Nachury, Nehrbass, Neumann, Onischenko, Onischenko, Otwinowski, Patel, Pyhtila, Rabut, Reichelt, Ren, Rout, Saksela, Savas, Schrader, Sheldrick, Theerthagiri, Weis, Weiss, Whittle, Winn, Xu, Yamada   +70 more
core   +2 more sources

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Molecular glue degraders (MGDs) constitute an emerging class of therapeutic agents poised to revolutionize the paradigm of targeted drug discovery. By reprogramming E3 ubiquitin ligases to degrade proteins of interest (POI) via a transient formation of a ternary complex mediated by protein–protein interactions, MGDs surpass the intrinsic limitations of
Jinfeng Wen, Jingtian Yu, Wuqiang Wen, Baishan Jiang   +3 more
wiley   +1 more source

Cytoplasmic nucleoporin assemblage: the cellular artwork in physiology and disease

Nucleus
Nucleoporins, essential proteins building the nuclear pore, are pivotal for ensuring nucleocytoplasmic transport. While traditionally confined to the nuclear envelope, emerging evidence indicates their presence in various cytoplasmic structures ...
Junyan Lin, Izabela Sumara
doaj   +1 more source

Calcium spiking patterns and the role of the calcium/calmodulin-dependent kinase CCaMK in lateral root base nodulation of Sesbania rostrata [PDF]

, 2009
Nodulation factor (NF) signal transduction in the legume-rhizobium symbiosis involves calcium oscillations that are instrumental in eliciting nodulation.
Capoen, Ward, Den Herder, Jeroen, Sun, Jongho, Verplancke, Christa, De Keyser, Annick, De Rycke, Riet, Goormachtig, Sofie, Oldroyd, Giles, Holsters, Marcella   +8 more
core   +2 more sources