Results 111 to 120 of about 14,867 (213)

Mitotic Phosphorylation of Nucleoporins: Dismantling NPCs and Beyond [PDF]

Developmental Cell, 2011
Recently reporting in Cell, Laurell et al. (2011) demonstrate that the hyperphosphorylation of vertebrate Nup98 by distinct mitotic kinases contributes to its release from nuclear pores, drives nuclear envelope permeabilization, and may provide a molecular switch coordinating nuclear envelope breakdown and spindle formation.
openaire   +2 more sources

Herpesvirus capsid association with the nuclear pore complex and viral DNA release involve the nucleoporin CAN/Nup214 and the capsid protein pUL25

, 2009
After penetrating the host cell, the herpesvirus capsid is transported to the nucleus along the microtubule network and docks to the nuclear pore complex before releasing the viral DNA into the nucleus. The viral and cellular interactions involved in the
Isidro, Anabela L., Blondel, Danielle, Rixon, Frazer J., Pasdeloup, D., Pasdeloup, David, Isidro, A.L., Rixon, F.J., Blondel, D.   +7 more
core   +1 more source

Nucleoporin 43 inhibits NF-κB pathway by targeting TRAF6 in miiuy croaker, Miichthys miiuy

Comparative Immunology Reports
Tumor necrosis factor receptor-associated factor 6 (TRAF6) serves as a critical factor in the initiation of the NF-κB pathway and holds significance in modulating the inflammatory response.
Wenxin Li, Yan Xu, Qi Li, Tianjun Xu, Yuena Sun   +4 more
doaj   +1 more source

Structural requirements for the UBA domain of the mRNA export receptor Mex67 to bind its specific targets, the transcription elongation THO complex component Hpr1 and nucleoporin FXFG repeats.

, 2009
International audienceThe Ubiquitin-Associated domain (UBA) domain of the principal Saccharomyces cerevisiae mRNA nuclear export factor, Mex67, can bind both nuclear pore protein (nucleoporin) FG repeats and Hpr1, a component of the TREX:THO complex that
Divita, Gilles, Neuhaus, David, Brockmann, Christoph, Dargemont, Catherine, Gruessing, Florian, Stewart, Murray, Hobeika, Maria   +6 more
core   +1 more source

The RNA export factor Mex67 functions as a mobile nucleoporin

, 2019
International audienceThe RNA export factor Mex67 is essential for the transport of mRNA through the nuclear pore complex (NPC) in yeast, but the molecular mechanism of this export process remains poorly understood. Here, we use quantitative fluorescence
Dultz, Elisa; id_orcid, Pascal Vallotton, Derrer, Carina P., Vallotton, Pascal, Mancini, Roberta, Carina Patrizia Derrer, Dultz, Elisa, Elisa Dultz, Karsten Weis, Huet, Sébastien, Derrer, Carina Patrizia, Roberta Mancini, Weis, Karsten, Sébastien Huet, Derrer CP, Vallotton P, Dultz E, Mancini R, Huet S, Weis K   +19 more
core   +1 more source

Major binding sites for the nuclear import receptor are the internal nucleoporin Nup153 and the adjacent nuclear filament protein Tpr

, 1998
A major question in nuclear import concerns the identity of the nucleoporin(s) that interact with the nuclear localization sequences (NLS) receptor and its cargo as they traverse the nuclear pore.
Sundeep Shah, Stuart Tugendreich, Douglass Forbes   +2 more
core  

The nucleoporin 153, a novel factor in double-strand break repair and DNA damage response

, 2012
International audienceDNA repair is essential in maintaining genome integrity and defects in different steps of the process have been linked to cancer and aging.
Genet, Diane, Lopez, Bernard s, Brino, Laurent, Bertrand, Pascale, Guirouilh-Barbat, Josée, Shahar, Or David, Fischer, Benoit, Soutoglou, Evi, Hoffbeck, Anne-Sophie, Lemaitre, Charlène, Kalousi, Alkmini, Goldberg, Michal   +11 more
core   +1 more source

Structural basis for a nucleoporin exportin complex between RanBP2, SUMO1-RanGAP1, the E2 Ubc9, Crm1 and the Ran GTPase

Nature Communications
The human nucleoporin RanBP2/Nup358 interacts with SUMO1-modified RanGAP1 and the SUMO E2 Ubc9 at the nuclear pore complex (NPC) to promote export and disassembly of exportin Crm1/Ran(GTP)/cargo complexes.
Vladimir Baytshtok, Michael A. DiMattia, Christopher D. Lima   +2 more
doaj   +1 more source

Nic96p is required for nuclear pore formation and functionally interacts with a novel nucleoporin, Nup188p

, 1996
The amino-terminal domain of Nic96p physically interacts with the Nsp1p complex which is involved in nucleocytoplasmic transport. Here we show that thermosensitive mutations mapping in the central domain of Nic96p inhibit nuclear pore formation at the ...
Wepf, Roger, Doye, Valérie, Grandi, Paola, V Doye, E C Hurt, Hurt, Eduard C., U Zabel, H Tekotte, Tekotte, Hildegard, R Wepf, P Grandi, Zabel, Ulrike   +11 more
core   +1 more source

Phosphorylation of ELYS promotes its interaction with VAPB at decondensing chromosomes during mitosis

EMBO Reports
ELYS is a nucleoporin that localizes to the nuclear side of the nuclear pore complex (NPC) in interphase cells. In mitosis, it serves as an assembly platform that interacts with chromatin and then with nucleoporin subcomplexes to initiate post-mitotic ...
Christina James, Ulrike Möller, Christiane Spillner, Sabine König, Olexandr Dybkov, Henning Urlaub, Christof Lenz, Ralph H Kehlenbach   +7 more
doaj   +1 more source