Results 101 to 110 of about 19,822 (225)

Specific Nucleoporin Requirement for Smad Nuclear Translocation [PDF]

Molecular and Cellular Biology, 2010
Cytoplasm-to-nucleus translocation of Smad is a fundamental step in transforming growth factor beta (TGF-beta) signal transduction. Here we identify a subset of nucleoporins that, in conjunction with Msk (Drosophila Imp7/8), specifically mediate activation-induced nuclear translocation of MAD (Drosophila Smad1) but not the constitutive import of ...
Xiaochu, Chen, Lan, Xu
openaire   +2 more sources

Targeting the nuclear export receptor exportin‐1 in acute myeloid leukaemia: From biology to clinical translation

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
• XPO1 hyperactivation promotes leukaemogenesis by altering nucleocytoplasmic transport and transcriptional control in acute myeloid leukaemia (AML). • Selinexor and eltanexor show preferential activity in NPM1‐mutated, DEK::NUP214‐positive and SF3B1‐mutated myeloid neoplasms.
Yifan Liu, Xiaoya Yun, Weidong Ding, Suxiao Li, Hui Liu   +4 more
wiley   +1 more source

Importin 7 and Nup358 promote nuclear import of the protein component of human telomerase.

PLoS ONE, 2014
In actively dividing eukaryotic cells, chromosome ends (telomeres) are subject to progressive shortening, unless they are maintained by the action of telomerase, a dedicated enzyme that adds DNA sequence repeats to chromosomal 3'end.
Cornelia Frohnert, Saskia Hutten, Sarah Wälde, Annegret Nath, Ralph H Kehlenbach   +4 more
doaj   +1 more source

Discovery of 4‐Quinazolinone‐Containing Phenylalanine Derivatives as Potent, Resistant‐Tolerant HIV Capsid Inhibitors

MedComm, Volume 7, Issue 5, May 2026.
Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Xujie Zhang, Lin Sun, Laura Walsham, Yuexi Ma, Dang Ding, Mei Wang, Fabao Zhao, Jian Zhang, Zhao Wang, Shujing Xu, Xiangyi Jiang, Yang Zhou, Erik De Clercq, Christophe Pannecouque, Chin‐Ho Chen, David C. Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan   +18 more
wiley   +1 more source

A SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits

Nature Communications, 2018
The nuclear pore complex is crucial for mediating nucleocytoplasmic exchanges. Here the authors use budding yeast to reveal a mechanism responsible of maintaining nucleoporin homeostasis by sensing changes in the complex integrity and further altering ...
Jérôme O. Rouvière, Manuel Bulfoni, Alex Tuck, Bertrand Cosson, Frédéric Devaux, Benoit Palancade   +5 more
doaj   +1 more source

An Arabidopsis Nucleoporin NUP85 modulates plant responses to ABA and salt stress. [PDF]

PLoS Genetics, 2017
Several nucleoporins in the nuclear pore complex (NPC) have been reported to be involved in abiotic stress responses in plants. However, the molecular mechanism of how NPC regulates abiotic stress responses, especially the expression of stress responsive
Yingfang Zhu, Bangshing Wang, Kai Tang, Chuan-Chih Hsu, Shaojun Xie, Hai Du, Yuting Yang, Weiguo Andy Tao, Jian-Kang Zhu   +8 more
doaj   +1 more source

Transmembrane Protein GbTMEM209 Inhibits Fibre Elongation via Competitive Interaction With GbHOX3 in Gossypium barbadense

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3087-3105, May 2026.
ABSTRACT Sea Island cotton (Gossypium barbadense) produces premium‐quality fibres, yet the genetic basis underlying its fibre development remains elusive. Here, we identify two key non‐synonymous single nucleotide polymorphisms (SNPs, G/C and G/A) in the gene Gbar_D13G024080, which encodes the TRANSMEMBRANE PROTEIN 209 (TMEM209). These SNPs resulted in
Kaiyun Jiang, Nan Zhao, Jie Kong, Anhui Guo, Yuqi Liu, Meng Wang, Zixin Zhou, Mengling Sun, Weiran Wang, Jiahui Zhu, Daojun Yuan, Zhuanxia Pan, Pengbo Li, Suen Liu, Baosheng Guo, Huijing Li, Jingrou Zhang, Bin Li, Zhanghao Xia, Beibei Lv, Junyi Geng, Baoliang Wang, Alifu Aierxi, Xianlong Zhang, Lili Tu, Jinping Hua   +25 more
wiley   +1 more source

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis

Nature Communications, 2016
As signalling molecules, bile acids (BAs) can affect metabolism, but due to detergent-like properties, BA levels must be tightly regulated. Here, Kim et al.show that RanBP2, a nucleoporin, maintains BA homoeostasis through SUMOylation of Small ...
Dong-Hyun Kim, Sanghoon Kwon, Sangwon Byun, Zhen Xiao, Sean Park, Shwu-Yuan Wu, Cheng-Ming Chiang, Byron Kemper, Jongsook Kim Kemper   +8 more
doaj   +1 more source

Nucleoporin mediated nuclear positioning and silencing of HMR. [PDF]

PLoS ONE, 2011
The organization of chromatin domains in the nucleus is an important factor in gene regulation. In eukaryotic nuclei, transcriptionally silenced chromatin clusters at the nuclear periphery while transcriptionally poised chromatin resides in the nuclear ...
Giulia J Ruben, Jacob G Kirkland, Tracy MacDonough, Miao Chen, Rudra N Dubey, Marc R Gartenberg, Rohinton T Kamakaka   +6 more
doaj   +1 more source

Differential Quantitative Proteomics of Human Microvascular Endothelial Cells 1 by iTRAQ Reveals Palladin to be a New Biomarker During TGF-β1 Induced Endothelial Mesenchymal Transition [PDF]

, 2017
The study uses global quantitative proteomics to investigate the molecular mechanisms behind the induction of endothelial-mesenchymal transition (EndMT) by transforming growth factor–β (TGF-β).
Bednarek, Radosław, Gawryś, Katarzyna, Popielarsk, Marcin, Sitkiewicz, Ewa, Stasiak, Marta, Studzian, Maciej, Swiatkowska, Maria, Szemraj, Janusz   +7 more
core   +1 more source