Results 101 to 110 of about 14,867 (213)
The nucleoporin Mlp2 is involved in chromosomal distribution during mitosis in trypanosomatids
, 2015 International audienceNucleoporins are evolutionary conserved proteins mainly involved in the constitution of the nuclear pores and trafficking between the nucleus and cytoplasm, but are also increasingly viewed as main actors in chromatin dynamics and ...
Crobu, Lucien +8 more
core +1 more source
A SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits
Nature Communications, 2018 The nuclear pore complex is crucial for mediating nucleocytoplasmic exchanges. Here the authors use budding yeast to reveal a mechanism responsible of maintaining nucleoporin homeostasis by sensing changes in the complex integrity and further altering ...
Jérôme O. Rouvière +5 more
doaj +1 more source
Importin 7 and Nup358 promote nuclear import of the protein component of human telomerase.
PLoS ONE, 2014 In actively dividing eukaryotic cells, chromosome ends (telomeres) are subject to progressive shortening, unless they are maintained by the action of telomerase, a dedicated enzyme that adds DNA sequence repeats to chromosomal 3'end.
Cornelia Frohnert +4 more
doaj +1 more source
, 2016 International audienceDuring M-phase entry in metazoans with open mitosis, the concerted action of mitotic kinases disassembles nuclei and promotes assembly of kinetochores—the primary microtubule attachment sites on chromosomes.
Dumont, Julien +8 more
core +1 more source
Nature Communications, 2016 As signalling molecules, bile acids (BAs) can affect metabolism, but due to detergent-like properties, BA levels must be tightly regulated. Here, Kim et al.show that RanBP2, a nucleoporin, maintains BA homoeostasis through SUMOylation of Small ...
Dong-Hyun Kim +8 more
doaj +1 more source
, 1999 We have analyzed the sorting of the mammalian nucleoporin p62 in human culture cells and in the yeast Saccharomyces cerevisiae. To this end, gene fusions were generated that carry Aequorea victoria green fluorescence protein and defined portions of p62 ...
Ursula Stochaj +2 more
core +1 more source
, 2023 Zi-Hao Li,1,* Jia-Yi Li,2,* Yong-Jie Zhu,1,3,* Lei Dai,3,* Zuo-Tao Wu,3 Ju-Sen Nong,4 Ting Zhuo,5 Fu-Li Li,1 Ling-Yun He,1 Hong-Hua Liang,1 Feng-Ling Zang,1 Yong-Yong Wang,3 Ming-Wu Chen,3 Wei-Jia Huang,1 Jian-Bin Cao1 1Department of ...
Nong JS +14 more
core
Moonlighting nuclear pore proteins: tissue-specific nucleoporin function in health and disease.
, 2018 The nuclear pore complex is the main transportation hub for exchange between the cytoplasm and the nucleus. It is built from nucleoporins that form distinct subcomplexes to establish this huge protein complex in the nuclear envelope.
Juhlen, Ramona Gabriele +1 more
core +1 more source
eLife, 2016 The permeability barrier of nuclear pore complexes (NPCs) controls bulk nucleocytoplasmic exchange. It consists of nucleoporin domains rich in phenylalanine-glycine motifs (FG domains). As a bottom-up nanoscale model for the permeability barrier, we have
Raphael Zahn +9 more
doaj +1 more source
Evolution of a transcriptional regulator from a transmembrane nucleoporin [PDF]
, 2016 Nuclear pore complexes (NPCs) emerged as nuclear transport channels in eukaryotic cells ∼1.5 billion years ago. While the primary role of NPCs is to regulate nucleo-cytoplasmic transport, recent research suggests that certain NPC proteins have ...
Hetzer, Martin W +7 more
core +1 more source