Results 51 to 60 of about 19,822 (225)

Ndc1 drives nuclear pore complex assembly independent of membrane biogenesis to promote nuclear formation and growth

eLife, 2022
The nuclear envelope (NE) assembles and grows from bilayer lipids produced at the endoplasmic reticulum (ER). How ER membrane incorporation coordinates with assembly of nuclear pore complexes (NPCs) to generate a functional NE is not well understood ...
Michael Sean Mauro, Gunta Celma, Vitaly Zimyanin, Magdalena M Magaj, Kimberley H Gibson, Stefanie Redemann, Shirin Bahmanyar   +6 more
doaj   +1 more source

Formation of the postmitotic nuclear envelope from extended ER cisternae precedes nuclear pore assembly [PDF]

, 2011
During mitosis, the nuclear envelope merges with the endoplasmic reticulum (ER), and nuclear pore complexes are disassembled. In a current model for reassembly after mitosis, the nuclear envelope forms by a reshaping of ER tubules.
Anderson, Anderson, Anderson, Antonin, Baumann, Belgareh, Bodoor, Burke, Chaudhary, Comings, Crisp, Cronshaw, Doucet, Drin, Dultz, Dultz, D’Angelo, Ehrlich, Ellenberg, Ferko, Franz, Gillespie, Goldberg, Haraguchi, Haraguchi, Haraguchi, Harel, Hetzer, Kiseleva, Kremer, Lei Lu, Lu, Macaulay, Mark S. Ladinsky, Mastronarde, Mastronarde, Maul, Patel, Puhka, Rabut, Rasala, Rasala, Rotem, Sheehan, Tomas Kirchhausen, Voeltz, Walther, Yang, Zuccolo   +48 more
core   +4 more sources

Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

eLife, 2018
HIV-1 accesses the nuclear DNA of interphase cells via a poorly defined process involving functional interactions between the capsid protein (CA) and nucleoporins (Nups).
Melissa Kane, Stephanie V Rebensburg, Matthew A Takata, Trinity M Zang, Masahiro Yamashita, Mamuka Kvaratskhelia, Paul D Bieniasz   +6 more
doaj   +1 more source

Case report: Compound heterozygous NUP85 variants cause autosomal recessive primary microcephaly

Frontiers in Neurology, 2023
Nucleoporin (NUP) 85 is a member of the Y-complex of nuclear pore complex (NPC) that is key for nucleocytoplasmic transport function, regulation of mitosis, transcription, and chromatin organization.
Ethiraj Ravindran, Ethiraj Ravindran, Ethiraj Ravindran, Gaetan Lesca, Gaetan Lesca, Louis Januel, Linus Goldgruber, Achim Dickmanns, Henri Margot, Angela M. Kaindl, Angela M. Kaindl, Angela M. Kaindl   +11 more
doaj   +1 more source

NUP214 (nucleoporin 214kDa) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on NUP214 (nucleoporin 214kDa), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +1 more source

Shaping the p53 Response with Nucleoporins [PDF]

Molecular Cell, 2012
In this issue, Singer et al. (2012) reveal that the nucleoporin Nup98 supports adaptation to genotoxic stress by protecting specific p53-induced mRNAs from exosome-dependent degradation, suggesting that wild-type Nup98 may possess tumor suppressor function.
Yarbrough, Melanie L., White, Michael A., Fontoura, Beatriz M.A.   +2 more
openaire   +2 more sources

Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity [PDF]

, 2009
L1-CAM (L1 cell-adhesion molecule), or more simply L1, plays an important role in the progression of human carcinoma. Overexpression promotes tumour-cell invasion and motility, growth in nude mice and tumour metastasis.
Riedle, Svenja, Kiefel, Helena, Gast, Daniela, Bondong, Sandra, Wolterink, Silke, Gutwein, Paul, Altevogt, Peter   +6 more
core   +2 more sources

Misregulation of Nucleoporins 98 and 96 leads to defects in protein synthesis that promote hallmarks of tumorigenesis

Disease Models & Mechanisms, 2022
Nucleoporin 98KD (Nup98) is a promiscuous translocation partner in hematological malignancies. Most disease models of Nup98 translocations involve ectopic expression of the fusion protein under study, leaving the endogenous Nup98 loci unperturbed ...
Ajai J. Pulianmackal, Kiriaki Kanakousaki, Kerry Flegel, Olga G. Grushko, Ella Gourley, Emily Rozich, Laura A. Buttitta   +6 more
doaj   +1 more source

Bone morphogenetic protein 7 sensitizes O6-methylguanine methyltransferase expressing-glioblastoma stem cells to clinically relevant dose of temozolomide. [PDF]

, 2015
BackgroundTemozolomide (TMZ) is an oral DNA-alkylating agent used for treating patients with glioblastoma. However, therapeutic benefits of TMZ can be compromised by the expression of O6-methylguanine methyltransferase (MGMT) in tumor tissue.
Bui, Yvonne, Cloughesy, Timothy F, Hong, Irene, Lai, Albert, Liau, Linda M, McBride, William H, Menjivar, Jimmy C, Nelson, Stanley F, Stream, Alexandra, Tso, Cho-Lea, Tso, Jonathan L, Yamada, Kazunari, Yang, Shuai, Yong, William H, Zhang, Yibei   +14 more
core   +2 more sources

NUP98 (nucleoporin 98 kDa) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2010
Review on NUP98 (nucleoporin 98 kDa), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +3 more sources