Results 51 to 60 of about 14,867 (213)
Nucleoporin-mediated regulation of cell identity genes [PDF]
, 2016 The organization of the genome in the three-dimensional space of the nucleus is coupled with cell type-specific gene expression. However, how nuclear architecture influences transcription that governs cell identity remains unknown.
Hetzer, Martin W +4 more
core +1 more source
Nucleoporin Nup98: a gatekeeper in the eukaryotic kingdoms [PDF]
Genes to Cells, 2010 The nucleoporin Nup98 is an essential component of the nuclear pore complex. This peripheral nucleoporin with its Gly‐Leu‐Phe‐Gly (GLFG) repeat domain contributes to nuclear‐cytoplasmic trafficking, including mRNA export. In addition, accumulating studies indicate that Nup98 plays roles in several important biological events such as gene expression ...
Masaaki, Iwamoto +3 more
openaire +2 more sources
Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2
eLife, 2018 HIV-1 accesses the nuclear DNA of interphase cells via a poorly defined process involving functional interactions between the capsid protein (CA) and nucleoporins (Nups).
Melissa Kane +6 more
doaj +1 more source
Rae1: A new clue for nucleoporin leukemias [PDF]
Cell Cycle, 2011 N ...
Stuwe, Tobias, Hoelz, André
openaire +3 more sources
Advanced Science, EarlyView.This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu +5 more
wiley +1 more source
Nup98 is a mobile nucleoporin with transcription-dependent dynamics
, 2002 Nucleoporin 98 (Nup98), a glycine-leucine-phenylalanine-glycine (GLFG) amino acid repeat-containing nucleoporin, plays a critical part in nuclear trafficking. Injection of antibodies to Nup98 into the nucleus blocks the export of most RNAs.
Griffis, Eric R. +3 more
core +1 more source
eLife, 2015 Nuclear pore complexes (NPCs) conduct massive transport mediated by shuttling nuclear transport receptors (NTRs), while keeping nuclear and cytoplasmic contents separated.
Hermann Broder Schmidt, Dirk Görlich
doaj +1 more source
Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.SuperResNET is a powerful integrated software that reconstructs network architecture and molecular distribution of subcellular structures from single molecule localization microscopy datasets. SuperResNET segments the nuclear pore complex and corners, extracts size, shape, and network features of all segmented nuclear pores and uses modularity analysis
Yahongyang Lydia Li +6 more
wiley +1 more source
Prion formation by a yeast GLFG nucleoporin [PDF]
Prion, 2012 The self-assembly of proteins into higher order structures is both central to normal biology and a dominant force in disease. Certain glutamine/asparagine (Q/N)-rich proteins in the budding yeast Saccharomyces cerevisiae assemble into self-replicating amyloid-like protein polymers, or prions, that act as genetic elements in an entirely protein-based ...
Halfmann, Randal Arthur +4 more
openaire +4 more sources
Nuclear Pore Proteins in Regulation of Chromatin State
Cells, 2019 Nuclear pore complexes (NPCs) are canonically known to regulate nucleocytoplasmic transport. However, research efforts over the last decade have demonstrated that NPCs and their constituent nucleoporins (Nups) also interact with the genome and perform ...
Terra M. Kuhn, Maya Capelson
doaj +1 more source