Results 11 to 20 of about 12,187 (136)
Multifunctionality of F-rich nucleoporins [PDF]
Biochemical Society Transactions, 2020 Nucleoporins (Nups) represent a range of proteins most known for composing the macromolecular assembly of the nuclear pore complex (NPC). Among them, the family of intrinsically disordered proteins (IDPs) phenylalanine-glycine (FG) rich Nups, form the permeability barrier and coordinate the high-speed nucleocytoplasmic transport in a selective way ...
Nike Heinß +3 more
openaire +2 more sources
Lipid Droplets Are a Physiological Nucleoporin Reservoir [PDF]
Cells, 2021 Lipid Droplets (LD) are dynamic organelles that originate in the Endoplasmic Reticulum and mostly bud off toward the cytoplasm, where they store neutral lipids for energy and protection purposes. LD also have diverse proteins on their surface, many of which are necessary for the their correct homeostasis.
Sylvain Kumanski +3 more
openaire +3 more sources
Autoproteolysis in nucleoporin biogenesis [PDF]
Proceedings of the National Academy of Sciences, 1999 We have molecularly characterized a proteolytic cleavage in conserved nuclear pore complex proteins. This cleavage, previously demonstrated to be essential for the biogenesis of two nuclear pore complex proteins in mammals (Nup98 and Nup96) and yeast (Nup145-N and Nup145-C), occurs between Phe and Ser residues within a highly conserved ...
J S, Rosenblum, G, Blobel
openaire +2 more sources
The Nuclear Life of Nucleoporins [PDF]
Developmental Cell, 2007 Nucleoporins are the constituents of the nuclear pore complex, but they are also known to shuttle to the nuclear interior, the function of which is unclear. In a recent issue of Nature Cell Biology, Wang et al.'s mechanistic studies of leukemogenic fusion proteins that contain nucleoporins suggest that they have a direct role in transcription.
Kalverda, Bernike, Fornerod, Maarten
openaire +2 more sources
Nucleoporins in cardiovascular disease
Journal of Molecular and Cellular Cardiology, 2020 Cardiovascular disease is a pressing health problem with significant global health, societal, and financial burdens. Understanding the molecular basis of polygenic cardiac pathology is thus essential to devising novel approaches for management and treatment.
Ryan D, Burdine +4 more
openaire +3 more sources
A mosaic of old and young nucleoporins [PDF]
Journal of Cell Biology, 2019 Some nucleoporins, the nuclear pore complex (NPC) components, have exceptionally long lifetimes. In this issue, Toyama et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201809123) report that NPCs are maintained by a slow piecemeal replacement of NPC components in dividing and terminally differentiated cells and by whole-pore exchange in ...
Takeshi Shimi, Hiroshi Kimura
openaire +2 more sources
Regulation of autophagy by nucleoporin Tpr [PDF]
Scientific Reports, 2012 The nuclear pore complex (NPC) consists of a conserved set of ~30 different proteins, termed nucleoporins, and serves as a gateway for the exchange of materials between the cytoplasm and nucleus. Tpr (translocated promoter region) is a component of NPC that presumably localizes at intranuclear filaments. Here, we show that Tpr knockdown caused a severe
Funasaka, Tatsuyoshi +2 more
openaire +2 more sources
Nucleoporin genes in human diseases [PDF]
European Journal of Human Genetics, 2016 Nuclear pore complexes (NPCs) are large channels spanning the nuclear envelope that mediate nucleocytoplasmic transport. They are composed of multiple copies of ~30 proteins termed nucleoporins (NUPs). Alterations in NUP genes are linked to several human neoplastic and non-neoplastic diseases.
Valeria, Nofrini +2 more
openaire +2 more sources
Shaping the p53 Response with Nucleoporins [PDF]
Molecular Cell, 2012 In this issue, Singer et al. (2012) reveal that the nucleoporin Nup98 supports adaptation to genotoxic stress by protecting specific p53-induced mRNAs from exosome-dependent degradation, suggesting that wild-type Nup98 may possess tumor suppressor function.
Yarbrough, Melanie L. +2 more
openaire +2 more sources
Nucleus, 2012 Transcriptional regulation is a complex process that requires the integrated action of many multi-protein complexes. The way in which a living cell coordinates the action of these complexes in time and space is still poorly understood. Recent work has shown that nuclear pores, well known for their role in 3' processing and export of transcripts, also ...
Sarma, Nayan J, Willis, Kristine
openaire +3 more sources