Results 11 to 20 of about 14,867 (213)
NUP214 (nucleoporin 214kDa) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2006 Review on NUP214 (nucleoporin 214kDa), with data on DNA, on the protein encoded, and where the gene is ...
Strehl, S, S Strehl
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The human nucleoporin Tpr protects cells from RNA-mediated replication stress [PDF]
Nature Communications, 2021 Tpr nucleoporin is known to be essential for nuclear transport and mitosis processes. Here the authors explore the link between Tpr and genome instability providing insights into the role of Tpr in safeguarding cells from RNA-mediated replication stress.
Martin Kosar +21 more
doaj +2 more sources
The Human NUP58 Nucleoporin Can Form Amyloids In Vitro and In Vivo
Biomedicines, 2021 Amyloids are fibrillar protein aggregates with a cross-β structure and unusual features, including high resistance to detergent or protease treatment.
Lavrentii G. Danilov +6 more
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An Arabidopsis Nucleoporin NUP85 modulates plant responses to ABA and salt stress. [PDF]
PLoS Genetics, 2017 Several nucleoporins in the nuclear pore complex (NPC) have been reported to be involved in abiotic stress responses in plants. However, the molecular mechanism of how NPC regulates abiotic stress responses, especially the expression of stress responsive
Yingfang Zhu +8 more
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Cells, 2022 Epigenetic deregulation plays an essential role in colorectal cancer progression. Bromodomains are epigenetic “readers” of histone acetylation. Bromodomain-containing protein 4 (BRD4) plays a pivotal role in transcriptional regulation and is a feasible ...
Hiroya Kondo +11 more
doaj +2 more sources
Nucleoporin-Related Leukemia: Nucleoporin rearrangements and their impact on nucleocytoplasmic transport and the proteome [PDF]
, 2020 Chromosomal rearrangements of the nucleoporin genes NUP214 and NUP98 are recurrent in aggressive cases of acute myeloid and lymphoid leukemias. NUP214 and NUP98 are components of the nuclear pore complex, a giant multiprotein structure that mediates ...
Rodrigues Mendes, Maria Adélia
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Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export [PDF]
Cell Reports, 2015 CRM1 is the major nuclear export receptor. During translocation through the nuclear pore, transport complexes transiently interact with phenylalanine-glycine (FG) repeats of multiple nucleoporins. On the cytoplasmic side of the nuclear pore, CRM1 tightly
Sarah A. Port +7 more
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Impact of distinct FG nucleoporin repeats on Nup98 self-association [PDF]
Nature CommunicationsNucleoporins rich in phenylalanine/glycine (FG) residues form the permeability barrier within the nuclear pore complex and are implicated in several pathological cellular processes, including oncogenic fusion condensates.
Alain Ibáñez de Opakua +4 more
doaj +2 more sources
A Nucleoporin at the Meiotic Kinetochore [PDF]
Developmental Cell, 2016 In this issue of Developmental Cell, Hattersley et al. (2016) use the unique biology of meiosis I, in which the cell can exit the division without reforming the nuclear envelope, to uncover an intriguing role of the nucleoporin MEL-28 in mediating chromosome segregation via its interaction with PP1 at the kinetochore.
Amanda M, Bonner, R Scott, Hawley
openaire +2 more sources
, 2022 International audienceMacroautophagy/autophagy is an essential process for cellular survival and is implicated in many diseases. A critical step in autophagy is the transport of the transcription factor TFEB from the cytosol into the nucleus, through the
Hayden, Michael +15 more
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