Results 11 to 20 of about 19,822 (225)
Dynamic rearrangement of nucleoporins during fungal "open" mitosis [PDF]
Molecular Biology of the Cell, 2008 Mitosis in animals starts with the disassembly of the nuclear pore complexes and the breakdown of the nuclear envelope. In contrast to many fungi, the corn smut fungus Ustilago maydis also removes the nuclear envelope.
Theisen, Ulrike +2 more
core +4 more sources
Lipid Droplets Are a Physiological Nucleoporin Reservoir [PDF]
Cells, 2021 Lipid Droplets (LD) are dynamic organelles that originate in the Endoplasmic Reticulum and mostly bud off toward the cytoplasm, where they store neutral lipids for energy and protection purposes.
Sylvain Kumanski +3 more
doaj +3 more sources
The new nucleoporin: Regulator of transcriptional repression and beyond [PDF]
Nucleus, 2012 Transcriptional regulation is a complex process that requires the integrated action of many multi-protein complexes. The way in which a living cell coordinates the action of these complexes in time and space is still poorly understood.
Sarma, Nayan J, Willis, Kristine
core +6 more sources
Multifunctionality of F-rich nucleoporins [PDF]
Biochemical Society Transactions, 2020 Nucleoporins (Nups) represent a range of proteins most known for composing the macromolecular assembly of the nuclear pore complex (NPC). Among them, the family of intrinsically disordered proteins (IDPs) phenylalanine-glycine (FG) rich Nups, form the permeability barrier and coordinate the high-speed nucleocytoplasmic transport in a selective way ...
Nike Heinß +3 more
openaire +2 more sources
Autoproteolysis in nucleoporin biogenesis [PDF]
Proceedings of the National Academy of Sciences, 1999 We have molecularly characterized a proteolytic cleavage in conserved nuclear pore complex proteins. This cleavage, previously demonstrated to be essential for the biogenesis of two nuclear pore complex proteins in mammals (Nup98 and Nup96) and yeast (Nup145-N and Nup145-C), occurs between Phe and Ser residues within a highly conserved ...
J S, Rosenblum, G, Blobel
openaire +2 more sources
Nucleoporin Nup62 maintains centrosome homeostasis [PDF]
Cell Cycle, 2013 Centrosomes are comprised of 2 orthogonally arranged centrioles surrounded by the pericentriolar material (PCM), which serves as the main microtubule organizing center of the animal cell. More importantly, centrosomes also control spindle polarity and orientation during mitosis.
Hashizume, Chieko +5 more
openaire +2 more sources
The Nuclear Life of Nucleoporins [PDF]
Developmental Cell, 2007 Nucleoporins are the constituents of the nuclear pore complex, but they are also known to shuttle to the nuclear interior, the function of which is unclear. In a recent issue of Nature Cell Biology, Wang et al.'s mechanistic studies of leukemogenic fusion proteins that contain nucleoporins suggest that they have a direct role in transcription.
Kalverda, Bernike, Fornerod, Maarten
openaire +2 more sources
Nucleoporins in cardiovascular disease
Journal of Molecular and Cellular Cardiology, 2020 Cardiovascular disease is a pressing health problem with significant global health, societal, and financial burdens. Understanding the molecular basis of polygenic cardiac pathology is thus essential to devising novel approaches for management and treatment.
Ryan D, Burdine +4 more
openaire +3 more sources
Nucleoporin genes in human diseases [PDF]
European Journal of Human Genetics, 2016 Nuclear pore complexes (NPCs) are large channels spanning the nuclear envelope that mediate nucleocytoplasmic transport. They are composed of multiple copies of ~30 proteins termed nucleoporins (NUPs). Alterations in NUP genes are linked to several human neoplastic and non-neoplastic diseases.
Valeria, Nofrini +2 more
openaire +2 more sources
SuperResNET: Model-Free Single-Molecule Network Analysis Software Achieves Molecular Resolution of Nup96. [PDF]
Adv Intell SystSuperResNET is a powerful integrated software that reconstructs network architecture and molecular distribution of subcellular structures from single molecule localization microscopy datasets. SuperResNET segments the nuclear pore complex and corners, extracts size, shape, and network features of all segmented nuclear pores and uses modularity analysis
Li YL +6 more
europepmc +2 more sources