Results 41 to 50 of about 159,475 (307)

Involvement of the lamin rod domain in heterotypic lamin interactions important for nuclear organization [PDF]

, 2001
The nuclear lamina is a meshwork of intermediate-type filament proteins (lamins) that lines the inner nuclear membrane. The lamina is proposed to be an important determinant of nuclear structure, but there has been little direct testing of this idea.
Tinglu Guan, Gerace, L, Eric C. Schirmer, Schirmer, Eric, Guan, T, Larry Gerace   +5 more
core   +1 more source

Nanocompartmentalization of the Nuclear Pore Lumen [PDF]

Biophysical Journal, 2020
The nuclear pore complex (NPC) employs the intrinsically disordered regions (IDRs) from a family of phenylalanine-glycine-rich nucleoporins (FG-Nups) to control nucleocytoplasmic transport. It has been a long-standing mystery how the IDR-mediated mass exchange can be rapid yet selective.
Kai Huang, Mario Tagliazucchi, Sung Hyun Park, Yitzhak Rabin, Igal Szleifer   +4 more
openaire   +3 more sources

NUP-1 is a large coiled-coil nucleoskeletal protein in Trypanosomes with lamin-like functions [PDF]

, 2012
A unifying feature of eukaryotic nuclear organization is genome segregation into transcriptionally active euchromatin and transcriptionally repressed heterochromatin.
Wan, Yakun, Kelly N DuBois, J. David Barry, Rout, Michael P., Alsford, S., Holden, Jennifer M., DuBois, K.N., Rout Michael P., Rout, Michael P, Jean-Mathieu Bart (176093), Field, Mark C, DuBois, Kelly N., Alsford Sam, Aitchison, J.D., Buisson, J., Mathieu Bart, Barry, J. David, Navarro Miguel, Horn David, Field, Mark C., Field Mark C., Misteli, T., Ratushny, Alexander V., Swiderski, Michal, Horn, David, Rout, M.P., Mark C. Field (129657), David Horn (24969), Jennifer M. Holden, Bastin Philippe, DuBois, Kelly N, Alexander V. Ratushny (102304), Barry, J.D., Barry, J David, Holden Jennifer M., Miguel Navarro, Michal Swiderski (176090), John D. Aitchison (102330), Bart, J., Johanna Buisson, J David Barry, John D. Aitchison, Holden, Jennifer M, Bastin, Philippe, DuBois Kelly N., Navarro, M., Barry J. David, Philippe Bastin (25974), Michael P. Rout (25373), Aitchison John D., Jennifer M Holden, Ratushny, A.V., Kelly N. Dubois, Buisson Johanna, Field, M.C., Alsford, Sam, Philippe Bastin, Swiderski, M., Wan, Y., Ratushny, Alexander V, Bastin, P., Kelly N. DuBois (176072), Horn, D., Michael P Rout, Aitchison, John D, Jean-Mathieu Bart, Buisson, Johanna, Bart, Jean-Mathieu, Sam Alsford (24967), Yakun Wan, David Horn, Mark C. Field, J. David Barry (60385), Navarro, Miguel, Aitchison, John D., Jennifer M. Holden (176080), Miguel Navarro (176103), Sam Alsford, Bart Jean-Mathieu, Ratushny Alexander V., Michael P. Rout, Yakun Wan (176097), Wan Yakun, Horn, David; id_orcid, Holden, J.M., Swiderski Michal, John D Aitchison, Mark C Field, Johanna Buisson (176084), Michal Swiderski, Er V. Ratushny, Alexander V Ratushny   +91 more
core   +1 more source

Characterization of the cellular functions of the nucleoporins Nup153 and Nup88 [PDF]

, 2010
Characterization of the Cellular Functions of the Nucleoporins Nup153 and Nup88 PhD Thesis, Yvonne Christine Lussi, 2010, University of Basel Nuclear pore complexes (NPCs) and nuclear lamins are major constituents of the nuclear envelope (NE) in ...
Lussi, Yvonne Christine
core   +1 more source

The nuclear pore primes recombination-dependent DNA synthesis at arrested forks by promoting SUMO removal

Nature Communications, 2020
In yeast, collapsed forks shift to the nuclear periphery to associate with two distinct perinuclear anchorage sites such as the nuclear pore complex. Here, the authors reveal the mechanisms engaged at nuclear pore complex facilitating fork integrity and ...
Karol Kramarz, Kamila Schirmeisen, Virginie Boucherit, Anissia Ait Saada, Claire Lovo, Benoit Palancade, Catherine Freudenreich, Sarah A. E. Lambert   +7 more
doaj   +1 more source

Human RTEL1 Interacts with KPNB1 (Importin β) and NUP153 and Connects Nuclear Import to Nuclear Envelope Stability in S-Phase

Cells, 2023
Regulator of TElomere Length Helicase 1 (RTEL1) is a helicase required for telomere maintenance and genome replication and repair. RTEL1 has been previously shown to participate in the nuclear export of small nuclear RNAs.
Michael Schertzer, Laurent Jullien, André L. Pinto, Rodrigo T. Calado, Patrick Revy, Arturo Londoño-Vallejo   +5 more
doaj   +1 more source

Nuclear Pore Complexes Cluster in Dysmorphic Nuclei of Normal and Progeria Cells during Replicative Senescence

Cells, 2021
Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disease caused by a mutation in LMNA. A G608G mutation in exon 11 of LMNA is responsible for most HGPS cases, generating a truncated protein called “progerin”.
Jennifer M. Röhrl, Rouven Arnold, Karima Djabali   +2 more
doaj   +1 more source

An Endoribonuclease Functionally Linked to Perinuclear mRNP Quality Control Associates with the Nuclear Pore Complexes

, 2009
Nuclear mRNA export is a crucial step in eukaryotic gene expression, which is in yeast coupled to cotranscriptional messenger ribonucleoprotein particle ( mRNP) assembly and surveillance.
Attila Rácz, Skružný Michal, Julan Weng, Racz, Attila, Ed Hurt, Rácz Attila, Weng Julan, David Tollervey, Schneider, Claudia, Hurt, Ed, Skruzny, Michal, Hurt Ed, Claudia Schneider, Schneider Claudia, Weng, Julan, Tollervey, David, Michal Skruzný, Tollervey David   +17 more
core   +1 more source

Organellar proteomics: the prizes and pitfalls of opening the nuclear envelope [PDF]

, 2002
Proteomic studies have the potential to comprehensively define the composition of organelles but are limited by the organellar cross-contamination that arises during subcellular fractionation.
Gerace, Larry, Schirmer, Eric C
core   +1 more source

Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis

Nature Communications, 2019
Although defects in nucleocytoplasmic transport (NCT) may be central to the pathogenesis of ALS, the molecular mechanisms modulating the nuclear pore function are still largely unknown.
Anthony Giampetruzzi, Eric W. Danielson, Valentina Gumina, Maryangel Jeon, Sivakumar Boopathy, Robert H. Brown, Antonia Ratti, John E. Landers, Claudia Fallini   +8 more
doaj   +1 more source