Results 11 to 20 of about 1,855,818 (295)

The nuclear pore complex [PDF]

Journal of Cell Biology, 1993
Over the past years, significant progress has been made both in the analysis of the structural and molecular organization of the nuclear pore complex (NPC) and the mechanism of nuclear transport. In this minireview, I will focus on some of the recent developments in this field.
Panté N, Aebi U
exaly   +7 more sources

Multifunctional roles of Brl1-Brr6 in nuclear envelope fusion during nuclear pore complex biogenesis [PDF]

The EMBO Journal
Brl1 and Brr6 are integral membrane proteins of the yeast nuclear envelope (NE) that transiently associate with nuclear pore complexes (NPCs). The exact roles of Brl1 and Brr6 during NPC assembly are unclear.
Sayan Mondal, Annett Neuner, Azqa Ajmal Khan, Jlenia Vitale, Elmar Schiebel   +4 more
doaj   +2 more sources

RanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion [PDF]

Nature Communications
Nuclear pore complexes (NPCs) enable nucleocytoplasmic transport. While NPCs primarily localize to the nuclear envelope (NE), they also appear in cytoplasmic endoplasmic reticulum (ER) membranes called annulate lamellae (AL). Though discovered in the mid-
Junyan Lin, Arantxa Agote-Aran, Yongrong Liao, Mehdi Cloarec, Leonid Andronov, Rafael L. Schoch, Paolo Ronchi, Victor Cochard, Rui Zhu, Erwan Grandgirard, Xiaotian Liu, Marianne Victoria Lemée, Charlotte Kleiss, Christelle Golzio, Marc Ruff, Guillaume Chevreux, Yannick Schwab, Bruno P. Klaholz, Izabela Sumara   +18 more
doaj   +2 more sources

The nuclear envelope and nuclear pore complexes in neurodegenerative diseases [PDF]

Frontiers in Cell and Developmental Biology
The nuclear envelope (NE) and nuclear pore complexes (NPCs) play a critical role in maintaining the balance between the nucleus and cytoplasm, which is essential for the structural integrity and gene regulatory functions of eukaryotic cells.
Tingyan Wu, Tingyan Wu, Haochen Xu, Haochen Xu, Lei Cheng, Lei Cheng, Ruoxin Wu, Ruoxin Wu, Fuzheng Guo, Xi Chen, Xi Chen   +10 more
doaj   +2 more sources

Protocol to image and quantify nuclear pore complexes using high-resolution laser scanning confocal microscopy

STAR Protocols, 2023
Summary: Nuclear pore complexes are pathways for nuclear-cytoplasmic communication that participate in chromatin organization. Here, we present a protocol to image and quantify the number of nuclear pore complexes in cells.
Jocelyn D. Mich-Basso, Bernhard Kühn
doaj   +1 more source

The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei

Acta Neuropathologica Communications, 2021
Nuclear pore complex injury has recently emerged as an early and significant contributor to familial and sporadic ALS disease pathogenesis. However, the molecular events leading to this pathological phenomenon characterized by the reduction of specific ...
Alyssa N. Coyne, Jeffrey D. Rothstein
doaj   +1 more source

Structure, function and assembly of nuclear pore complexes [PDF]

Nature Reviews Molecular Cell Biology
Stefan Petrović, André Hoelz
exaly   +2 more sources

Weaving a pattern from disparate threads: lamin function in nuclear assembly and DNA replication [PDF]

, 1994
The major residual structure that remains associated with the nuclear envelope following extraction of isolated nuclei or oocyte germinal vesicles with non-ionic detergents, nucleases and high salt is the lamina (Fawcett, 1966; Aaronson and Blobel ...
Hutchison, CJ, Kill, IR, Bridger, JM, Cox, LS   +3 more
core   +6 more sources

A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis

Open Biology, 2021
The integral membrane protein Apq12 is an important nuclear envelope (NE)/endoplasmic reticulum (ER) modulator that cooperates with the nuclear pore complex (NPC) biogenesis factors Brl1 and Brr6. How Apq12 executes these functions is unknown.
Wanlu Zhang, Azqa Khan, Jlenia Vitale, Annett Neuner, Kerstin Rink, Christian Lüchtenborg, Britta Brügger, Thomas H. Söllner, Elmar Schiebel   +8 more
doaj   +1 more source

Glycosylation of the Nuclear Pore [PDF]

Traffic, 2014
The O‐linked β‐N‐acetylglucosamine (O‐GlcNAc) posttranslational modification was first discovered 30 years ago and is highly concentrated in the nuclear pore. In the years since the discovery of this single sugar modification, substantial progress has been made in understanding the biochemistry of O‐GlcNAc and its regulation.
Bin, Li, Jennifer J, Kohler
openaire   +2 more sources