Direct Visualization of Single Nuclear Pore Complex Proteins Using Genetically-Encoded Probes for DNA-PAINT. [PDF]
Angew Chem Int Ed Engl, 2019 The Nuclear Pore Complex (NPC) is one of the largest and most complex protein assemblies in the cell and – among other functions – serves as the gatekeeper of nucleocytoplasmic transport.
Schlichthaerle T +10 more
europepmc +3 more sources
Nuclear pore complex proteins are involved in centromere distribution [PDF]
iScienceSummary: The subnuclear distribution of centromeres is cooperatively regulated by condensin II and the linker of nucleoskeleton and cytoskeleton (LINC) complex.
Nanami Ito +6 more
doaj +4 more sources
Dynamics and diverse functions of nuclear pore complex proteins. [PDF]
Nucleus, 2012 Nuclear pore complexes (NPCs) are best known for their central role in controlling the molecular trafficking between the cytoplasm and the nucleus. NPCs are assembled from about 30 different proteins and a growing body of evidence suggests that these ...
Chatel G, Fahrenkrog B.
europepmc +6 more sources
A new family of yeast nuclear pore complex proteins. [PDF]
Journal of Cell Biology, 1992 We have identified a novel family of yeast nuclear pore complex proteins. Three individual members of this family, NUP49, NUP100, and NUP116, have been isolated and then characterized by a combination of molecular genetics and immunolocalization ...
Michael Rout, Blobel G, Rout M P
exaly +4 more sources
Partial Disassembly of the Nuclear Pore Complex Proteins during Semi-Closed Mitosis in Dictyostelium discoideum [PDF]
Cells, 2022 Dictyostelium cells undergo a semi-closed mitosis, during which the nuclear envelope (NE) persists; however, free diffusion between the cytoplasm and the nucleus takes place.
Kristina Mitic +3 more
doaj +2 more sources
Nuclear Pore Complex Proteins in Alzheimer Disease [PDF]
Journal of Neuropathology and Experimental Neurology, 2006 Ultrastructural studies of neurofibrillary tangles in Alzheimer disease (AD) have demonstrated a close relationship between nuclear pores and the cytoplasmic paired helical filaments comprising the tangles, as well as nuclear irregularity in many tangle-bearing neurons; nuclear pore aggregation has been observed in nearby neurons.
L. G. Sheffield +3 more
semanticscholar +3 more sources
DNA origami scaffold for studying intrinsically disordered proteins of the nuclear pore complex
Nature Communications, 2018 FG-Nups are disordered proteins in the nuclear pore complex (NPC) where they selectively control nuclear transport. Here authors build NPC-mimics based on DNA origami rings which attach a certain numbers of Nups to analyse those nanopores by cryoEM and ...
Philip Ketterer +9 more
doaj +2 more sources
Proteins Connecting the Nuclear Pore Complex with the Nuclear Interior [PDF]
Journal of Cell Biology, 1999 While much has been learned in recent years about the movement of soluble transport factors across the nuclear pore complex (NPC), comparatively little is known about intranuclear trafficking. We isolated the previously identified Saccharomyces protein Mlp1p (myosin-like protein) by an assay designed to find nuclear envelope (NE) associated proteins ...
Gunter Blobel +2 more
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Interactions and three-dimensional localization of a group of nuclear pore complex proteins.
Journal of Cell Biology, 1994 We have used antibodies directed against a number of nuclear pore complex (NPC) proteins to determine their mutual interactions and location within the three-dimensional structure of the NPC.
Burke B
exaly +2 more sources
Genetic and physical interactions between Srp1p and nuclear pore complex proteins Nup1p and Nup2p.
Journal of Cell Biology, 1994 Nup1p is a yeast nuclear pore complex protein (nucleoporin) required for nuclear protein import, mRNA export and maintenance of normal nuclear architecture. We have used a genetic approach to identify other proteins that interact functionally with Nup1p.
K. Belanger, M. Kenna, S. Wei, L. Davis
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