Results 31 to 40 of about 97,972 (258)

Higher nucleoporin-Importinβ affinity at the nuclear basket increases nucleocytoplasmic import.

PLoS ONE, 2013
Several in vitro studies have shown the presence of an affinity gradient in nuclear pore complex proteins for the import receptor Importinβ, at least partially contributing to nucleocytoplasmic transport, while others have historically argued against the
Mohammad Azimi, Mohammad R K Mofrad
doaj   +1 more source

hnRNPA3 regulates hESCs pluripotency through modulating mRNA export [PDF]

Jichu yixue yu linchuang, 2021
Objective To explore the biological function of RNA binding protein heterogeneous nuclear ribonucleoprotein A3(hnRNPA3) in the maintenance of pluripotency of human embryonic stem cells(hESCs) and to reveal its new mechanism in RNA transport.
YANG Jia-bin, CHEN Zhong-yang, ZHOU Fan-qi, YU Jia, MA Yan-ni
doaj  

The HSV1 Tail-Anchored Membrane Protein pUL34 Contains a Basic Motif That Supports Active Transport to the Inner Nuclear Membrane Prior to Formation of the Nuclear Egress Complex

Viruses, 2021
Herpes simplex virus type 1 nucleocapsids are released from the host nucleus by a budding process through the nuclear envelope called nuclear egress. Two viral proteins, the integral membrane proteins pUL34 and pUL31, form the nuclear egress complex at ...
Christina Funk, Débora Marques da Silveira e Santos, Melanie Ott, Verena Raschbichler, Susanne M. Bailer   +4 more
doaj   +1 more source

Assembly of nuclear pore complexes mediated by major vault protein [PDF]

Journal of Cell Science, 2009
During interphase growth of eukaryotic cells, nuclear pore complexes (NPCs) are continuously incorporated into the intact nuclear envelope (NE) by mechanisms that are largely unknown. De novo formation of NPCs involves local fusion events between the inner and outer nuclear membrane, formation of a transcisternal membranous channel of defined diameter ...
Friederike, Vollmar, Christian, Hacker, René-Peiman, Zahedi, Albert, Sickmann, Andrea, Ewald, Ulrich, Scheer, Marie-Christine, Dabauvalle   +6 more
openaire   +2 more sources

DNA origami scaffold for studying intrinsically disordered proteins of the nuclear pore complex

Nature Communications, 2018
FG-Nups are disordered proteins in the nuclear pore complex (NPC) where they selectively control nuclear transport. Here authors build NPC-mimics based on DNA origami rings which attach a certain numbers of Nups to analyse those nanopores by cryoEM and ...
Philip Ketterer, Adithya N. Ananth, Diederik S. Laman Trip, Ankur Mishra, Eva Bertosin, Mahipal Ganji, Jaco van der Torre, Patrick Onck, Hendrik Dietz, Cees Dekker   +9 more
doaj   +1 more source

Progress in the study of parvovirus entry pathway

Virology Journal, 2023
A group of DNA viruses called parvoviruses that have significant effects on cancer therapy and genetic engineering applications. After passing through the cell membrane to reach the cytosol, it moves along the microtubule toward the nuclear membrane. The
Jiuming Shi, Yifeng Pei, Qian Yu, Hao dong   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Intranuclear filaments containing a nuclear pore complex protein. [PDF]

The Journal of cell biology, 1993
Nuclear pore complexes (NPCs) are anchoring sites of intranuclear filaments of 3-6 nm diameter that are coaxially arranged on the perimeter of a cylinder and project into the nuclear interior for lengths varying in different kinds of cells. Using a specific monoclonal antibody we have found that a polypeptide of approximately 190 kD on SDS-PAGE, which ...
V C, Cordes, S, Reidenbach, A, Köhler, N, Stuurman, R, van Driel, W W, Franke   +5 more
openaire   +2 more sources

Nuclear basket proteins regulate the distribution and mobility of nuclear pore complexes in budding yeast

Molecular Biology of the Cell, 2023
Nuclear pore complexes (NPCs) mediate all traffic between the nucleus and the cytoplasm and are among the most stable protein assemblies in cells. Budding yeast cells carry two variants of NPCs which differ in the presence or absence of the nuclear basket proteins Mlp1, Mlp2 and Pml39.
Janka Zsok, Francois Simon, Göksu Bayrak, Luljeta Isaki, Nina Kerff, Yoana Kicheva, Amy Wolstenholme, Lucien E. Weiss, Elisa Dultz   +8 more
openaire   +3 more sources

Hop-on hop-off: importin-a-guided tours to the nucleus in innate immune signaling

Frontiers in Plant Science, 2013
Nuclear translocation of immune regulatory proteins and signal transducers is an essential process in animal and plant defense signaling against pathogenic microbes.
Lennart eWirthmueller, Charlotte eRoth, Mark J. Banfield, Marcel eWiermer   +3 more
doaj   +1 more source