Results 31 to 40 of about 173,033 (291)
Frontiers in Chemistry, 2018 Biosensors based on plasmonic nanostructures offer label-free and real-time monitoring of biomolecular interactions. However, so do many other surface sensitive techniques with equal or better resolution in terms of surface coverage.
Bita Malekian +8 more
doaj +1 more source
Protein Transport by the Nuclear Pore Complex: Simple Biophysics of a Complex Biomachine [PDF]
Biophysical Journal, 2017 In eukaryotic cells, transport of molecules between the nucleus and the cytoplasm is facilitated by highly selective and efficient biomachines known as nuclear pore complexes (NPCs). The structural details of NPCs vary across species, with many of their constituent proteins exhibiting relatively low sequence conservation; yet the NPC as a whole retains
Tijana, Jovanovic-Talisman +1 more
openaire +2 more sources
Communications Biology, 2022 The development of an image splitter based multi-colour single-molecule localization microscopy method (splitSMLM) in combination with a spectral demixing algorithm improves localization accuracy as exemplified by three-colour imaging of nuclear pore ...
Leonid Andronov +3 more
doaj +1 more source
NucEnvDB: A Database of Nuclear Envelope Proteins and Their Interactions
Membranes, 2023 The nuclear envelope (NE) is a double-membrane system surrounding the nucleus of eukaryotic cells. A large number of proteins are localized in the NE, performing a wide variety of functions, from the bidirectional exchange of molecules between the ...
Fotis A. Baltoumas +4 more
doaj +1 more source
Molecules and Cells, 2021 mRNA translation is coupled to multiprotein complex assembly in the cytoplasm or to protein delivery into intracellular compartments. Here, by combining systematic RNA immunoprecipitation and single-molecule RNA imaging in yeast, we have provided a ...
Ophélie Lautier +9 more
semanticscholar +1 more source
Characterization of a nuclear pore protein sheds light on the roles and composition of the Toxoplasma gondii nuclear pore complex [PDF]
Cellular and Molecular Life Sciences, 2017 The nuclear pore is a key structure in eukaryotes regulating nuclear-cytoplasmic transport as well as a wide range of cellular processes. Here, we report the characterization of the first Toxoplasma gondii nuclear pore protein, named TgNup302, which appears to be the orthologue of the mammalian Nup98-96 protein.
Courjol, Flavie +9 more
openaire +2 more sources
Nuclear Envelope Regulation of Oncogenic Processes: Roles in Pancreatic Cancer
Epigenomes, 2018 Pancreatic cancer is an aggressive and intractable malignancy with high mortality. This is due in part to a high resistance to chemotherapeutics and radiation treatment conferred by diverse regulatory mechanisms.
Claudia C. Preston +1 more
doaj +1 more source
Components of coated vesicles and nuclear pore complexes share a common molecular architecture.
PLoS Biology, 2004 Numerous features distinguish prokaryotes from eukaryotes, chief among which are the distinctive internal membrane systems of eukaryotic cells. These membrane systems form elaborate compartments and vesicular trafficking pathways, and sequester the ...
Damien Devos +6 more
doaj +1 more source
The Nuclear Pore Complex as a Transcription Regulator.
Cold Spring Harbor Perspectives in Biology, 2021 The nuclear pore complex (NPC) is a highly conserved channel in the nuclear envelope that mediates mRNA export to the cytosol and bidirectional protein transport.
M. Sumner, Jason H. Brickner
semanticscholar +1 more source
The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import [PDF]
The Journal of Cell Biology, 2002 The nuclear pore complex (NPC) mediates bidirectional macromolecular traffic between the nucleus and cytoplasm in eukaryotic cells. Eight filaments project from the NPC into the cytoplasm and are proposed to function in nuclear import. We investigated the localization and function of two nucleoporins on the cytoplasmic face of the NPC, CAN/Nup214 and ...
Walther, T. C. +6 more
openaire +5 more sources