Results 31 to 40 of about 8,068,483 (291)

Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery [PDF]

, 2013
BACKGROUND: Different cell types have distinctive patterns of chromosome positioning in the nucleus. Although ectopic affinity-tethering of specific loci can be used to relocate chromosomes to the nuclear periphery, endogenous nuclear envelope proteins ...
Vassiliki Lazou, Harrison, David J, Schirmer, Eric C, David J Harrison, Zuleger, Nikolaj, de Las Heras, Jose I, Wendy A Bickmore, Dzmitry G Batrakou, Lazou, Vassiliki, Batrakou, Dzmitry G, Jose I de las Heras, Bickmore, Wendy A, Nikolaj Zuleger, Shelagh Boyle, Kelly, David A, Korfali, Nadia, Nadia Korfali, Glenn E Morris, Eric C Schirmer, Boyle, Shelagh, David A Kelly, K Natalie Randles, Randles, K Natalie, Morris, Glenn E   +23 more
core   +1 more source

Characterization of a nuclear pore protein sheds light on the roles and composition of the Toxoplasma gondii nuclear pore complex [PDF]

Cellular and Molecular Life Sciences, 2017
The nuclear pore is a key structure in eukaryotes regulating nuclear-cytoplasmic transport as well as a wide range of cellular processes. Here, we report the characterization of the first Toxoplasma gondii nuclear pore protein, named TgNup302, which appears to be the orthologue of the mammalian Nup98-96 protein.
Courjol, Flavie, Mouveaux, Thomas, Lesage, Kevin, Saliou, Jean-Michel, Werkmeister, Elisabeth, Bonabaud, Maurine, Rohmer, Marine, Slomianny, Christian, Lafont, Franck, Gissot, Mathieu   +9 more
openaire   +2 more sources

Involvement of the lamin rod domain in heterotypic lamin interactions important for nuclear organization [PDF]

, 2001
The nuclear lamina is a meshwork of intermediate-type filament proteins (lamins) that lines the inner nuclear membrane. The lamina is proposed to be an important determinant of nuclear structure, but there has been little direct testing of this idea.
Tinglu Guan, Gerace, L, Eric C. Schirmer, Schirmer, Eric, Guan, T, Larry Gerace   +5 more
core   +1 more source

Nuclear Envelope Regulation of Oncogenic Processes: Roles in Pancreatic Cancer

Epigenomes, 2018
Pancreatic cancer is an aggressive and intractable malignancy with high mortality. This is due in part to a high resistance to chemotherapeutics and radiation treatment conferred by diverse regulatory mechanisms.
Claudia C. Preston, Randolph S. Faustino   +1 more
doaj   +1 more source

Dynamic rearrangement of nucleoporins during fungal "open" mitosis [PDF]

, 2008
Mitosis in animals starts with the disassembly of the nuclear pore complexes and the breakdown of the nuclear envelope. In contrast to many fungi, the corn smut fungus Ustilago maydis also removes the nuclear envelope.
Theisen, Ulrike, Steinberg, Gero, Straube, Anne   +2 more
core   +1 more source

Components of coated vesicles and nuclear pore complexes share a common molecular architecture.

PLoS Biology, 2004
Numerous features distinguish prokaryotes from eukaryotes, chief among which are the distinctive internal membrane systems of eukaryotic cells. These membrane systems form elaborate compartments and vesicular trafficking pathways, and sequester the ...
Damien Devos, Svetlana Dokudovskaya, Frank Alber, Rosemary Williams, Brian T Chait, Andrej Sali, Michael P Rout   +6 more
doaj   +1 more source

The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import [PDF]

The Journal of Cell Biology, 2002
The nuclear pore complex (NPC) mediates bidirectional macromolecular traffic between the nucleus and cytoplasm in eukaryotic cells. Eight filaments project from the NPC into the cytoplasm and are proposed to function in nuclear import. We investigated the localization and function of two nucleoporins on the cytoplasmic face of the NPC, CAN/Nup214 and ...
Walther, T. C., Pickersgill, H. S., Cordes, V. C., Goldberg, M. W., Allen, T. D., Mattaj, I. W., Fornerod, M.   +6 more
openaire   +5 more sources

Characterization of the cellular functions of the nucleoporins Nup153 and Nup88 [PDF]

, 2010
Characterization of the Cellular Functions of the Nucleoporins Nup153 and Nup88 PhD Thesis, Yvonne Christine Lussi, 2010, University of Basel Nuclear pore complexes (NPCs) and nuclear lamins are major constituents of the nuclear envelope (NE) in ...
Lussi, Yvonne Christine
core   +1 more source

Silencing nuclear pore protein Tpr elicits a senescent-like phenotype in cancer cells.

PLoS ONE, 2011
BackgroundTpr is a large coiled-coil protein located in the nuclear basket of the nuclear pore complex for which many different functions were proposed from yeast to human.Methodology/principal findingsHere we show that depletion of Tpr by RNA ...
Brigitte David-Watine
doaj   +1 more source

Biochemical characterization of nuclear pore complex protein gp210 oligomers [PDF]

European Journal of Biochemistry, 2001
The membrane‐spanning glycoprotein gp210 is a major component of the nuclear pore complex. This nucleoporin contains a large cisternal N‐terminal domain, a short C‐terminal cytoplasmic tail, and a single transmembrane segment. We show here that dimers of native gp210 can be isolated from cell extracts by immunoprecipitation, and from purified rat liver
C, Favreau, R, Bastos, J, Cartaud, J C, Courvalin, P, Mustonen   +4 more
openaire   +2 more sources