Results 21 to 30 of about 191,852 (331)
ZC3HC1 has many functions distinct from TPR and is dispensable for TPR localisation to the nuclear basket [version 2; peer review: 1 approved, 4 approved with reservations] [PDF]
Wellcome Open ResearchBackground The nuclear basket is a ‘fishtrap’-like structure on the nucleoplasmic face of the nuclear pore complex which has been implicated in diverse functions including RNA export, heterochromatin organisation, and mitosis. Recently, a novel component
Wendy A Bickmore +2 more
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Dynamics and diverse functions of nuclear pore complex proteins. [PDF]
Nucleus, 2012 Nuclear pore complexes (NPCs) are best known for their central role in controlling the molecular trafficking between the cytoplasm and the nucleus. NPCs are assembled from about 30 different proteins and a growing body of evidence suggests that these nucleoporins are not only acting in the context of NPCs, but also in the nucleoplasm and cytoplasm.
Chatel G, Fahrenkrog B.
europepmc +4 more sources
eLife, 2016 Nuclear Pore Complexes (NPCs) are key cellular transporter that control nucleocytoplasmic transport in eukaryotic cells, but its transport mechanism is still not understood.
Andrei Vovk +7 more
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A complex of nuclear pore proteins required for pore function. [PDF]
The Journal of cell biology, 1991 A family of proteins bearing novel N-acetylglucosamine residues has previously been found to be required to form functional nuclear pores. To begin to determine which of the proteins in this family are essential for pore function, antisera were raised to each of three members of the family, p62, p58, and p54.
Deborah Finlay +4 more
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Protein Transport by the Nuclear Pore Complex: Simple Biophysics of a Complex Biomachine [PDF]
Biophysical Journal, 2017 In eukaryotic cells, transport of molecules between the nucleus and the cytoplasm is facilitated by highly selective and efficient biomachines known as nuclear pore complexes (NPCs). The structural details of NPCs vary across species, with many of their constituent proteins exhibiting relatively low sequence conservation; yet the NPC as a whole retains
Tijana Jovanović‐Talisman +1 more
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Acta Neuropathologica Communications, 2021 Nuclear pore complex injury has recently emerged as an early and significant contributor to familial and sporadic ALS disease pathogenesis. However, the molecular events leading to this pathological phenomenon characterized by the reduction of specific ...
Alyssa N. Coyne, Jeffrey D. Rothstein
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Nucleocytoplasmic Trafficking Perturbation Induced by Picornaviruses
Viruses, 2021 Picornaviruses are positive-stranded RNA viruses. Even though replication and translation of their genome take place in the cytoplasm, these viruses evolved different strategies to disturb nucleocytoplasmic trafficking of host proteins and RNA. The major
Belén Lizcano-Perret, Thomas Michiels
doaj +1 more source
Nature Communications, 2021 The involvement of nuclear pore proteins in cellular mechanosensing and metastasis is unclear. Here the authors identify that nuclear pore protein NUP210 promotes metastasis through the interaction with mechanotransducer LINC complex protein and ...
Ruhul Amin +17 more
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Nuclear Pore Complex Proteins in Alzheimer Disease [PDF]
Journal of Neuropathology and Experimental Neurology, 2006 Ultrastructural studies of neurofibrillary tangles in Alzheimer disease (AD) have demonstrated a close relationship between nuclear pores and the cytoplasmic paired helical filaments comprising the tangles, as well as nuclear irregularity in many tangle-bearing neurons; nuclear pore aggregation has been observed in nearby neurons.
Lynette G, Sheffield +3 more
openaire +2 more sources