Results 11 to 20 of about 97,972 (258)
Expression of DNAJB12 or DNAJB14 causes coordinate invasion of the nucleus by membranes associated with a novel nuclear pore structure. [PDF]
PLoS ONE, 2014 DNAJB12 and DNAJB14 are transmembrane proteins in the endoplasmic reticulum (ER) that serve as co-chaperones for Hsc70/Hsp70 heat shock proteins. We demonstrate that over-expression of DNAJB12 or DNAJB14 causes the formation of elaborate membranous ...
Edward C Goodwin +4 more
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Types of nuclear localization signals and mechanisms of protein import into the nucleus
Cell Communication and Signaling, 2021 Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus.
Juane Lu +6 more
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Deciphering Networks of Protein Interactions at the Nuclear Pore Complex [PDF]
Molecular & Cellular Proteomics, 2002 The nuclear pore complex (NPC) gates the only known conduit for molecular exchange between the nucleus and cytoplasm of eukaryotic cells. Macromolecular transport across the NPC is mediated by nucleocytoplasmic shuttling receptors termed karyopherins (Kaps).
Nadia P C, Allen +7 more
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Mitogen activated protein kinase at the nuclear pore complex [PDF]
Journal of Cellular and Molecular Medicine, 2011 Mitogen activated protein (MAP) kinases control eukaryotic proliferation, and import of kinases into the nucleus through the nuclear pore complex (NPC) can influence gene expression to affect cellular growth, cell viability and homeostatic function. The NPC is a critical regulatory checkpoint for nucleocytoplasmic traffic that regulates gene expression
Faustino, Randolph S +2 more
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Differential Mitotic Phosphorylation of Proteins of the Nuclear Pore Complex [PDF]
Journal of Biological Chemistry, 1995 During each cell cycle, the nucleus of higher eukaryotes undergoes a dramatic assembly and disassembly. These events can be faithfully reproduced in vitro using cell-free extracts derived from Xenopus eggs. Such extracts contain three major N-acetylglucosaminylated proteins, p200, p97, and p60.
C, Macaulay, E, Meier, D J, Forbes
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Herpesvirus Nuclear Egress across the Outer Nuclear Membrane
Viruses, 2021 Herpesvirus capsids are assembled in the nucleus and undergo a two-step process to cross the nuclear envelope. Capsids bud into the inner nuclear membrane (INM) aided by the nuclear egress complex (NEC) proteins UL31/34.
Richard J. Roller, David C. Johnson
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Frontiers in Chemistry, 2018 Biosensors based on plasmonic nanostructures offer label-free and real-time monitoring of biomolecular interactions. However, so do many other surface sensitive techniques with equal or better resolution in terms of surface coverage.
Bita Malekian +8 more
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Protein Transport by the Nuclear Pore Complex: Simple Biophysics of a Complex Biomachine [PDF]
Biophysical Journal, 2017 In eukaryotic cells, transport of molecules between the nucleus and the cytoplasm is facilitated by highly selective and efficient biomachines known as nuclear pore complexes (NPCs). The structural details of NPCs vary across species, with many of their constituent proteins exhibiting relatively low sequence conservation; yet the NPC as a whole retains
Tijana, Jovanovic-Talisman +1 more
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Communications Biology, 2022 The development of an image splitter based multi-colour single-molecule localization microscopy method (splitSMLM) in combination with a spectral demixing algorithm improves localization accuracy as exemplified by three-colour imaging of nuclear pore ...
Leonid Andronov +3 more
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NucEnvDB: A Database of Nuclear Envelope Proteins and Their Interactions
Membranes, 2023 The nuclear envelope (NE) is a double-membrane system surrounding the nucleus of eukaryotic cells. A large number of proteins are localized in the NE, performing a wide variety of functions, from the bidirectional exchange of molecules between the ...
Fotis A. Baltoumas +4 more
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