Results 11 to 20 of about 173,033 (291)
Differential Targeting of Nuclear Pore Complex Proteins in Poliovirus-Infected Cells [PDF]
Journal of Virology, 2007 Poliovirus disrupts nucleocytoplasmic trafficking and results in the cleavage of two nuclear pore complex (NPC) proteins, Nup153 and Nup62. The NPC is a 125-MDa complex composed of multiple copies of 30 different proteins.
Nogi Park +3 more
semanticscholar +3 more sources
The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins [PDF]
EMBO Journal, 2001 The nuclear pore complex (NPC) is a large proteinaceous structure through which bidirectional transport of macromolecules across the nuclear envelope (NE) takes place. Nup153 is a peripheral NPC component that has been implicated in protein and RNP transport and in the interaction of NPCs with the nuclear lamina. Here, Nup153 is localized by immunogold
Martin Goldberg +2 more
exaly +4 more sources
Quantitative regulation of nuclear pore complex proteins by O-GlcNAcylation.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2013 The nuclear pore complex (NPC) is a macromolecular assembly consisting of approximately 30 different proteins called nucleoporins. Several nucleoporins are O-GlcNAcylated, which is a post-translational modification in which the monosaccharide β-N-acetylglucosamine (GlcNAc) is attached to serine or threonine residues within proteins.
Chiaki Mizuguchi-Hata +3 more
semanticscholar +3 more sources
eLife, 2016 Nuclear Pore Complexes (NPCs) are key cellular transporter that control nucleocytoplasmic transport in eukaryotic cells, but its transport mechanism is still not understood.
Andrei Vovk +7 more
doaj +2 more sources
A designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complex
Nature Communications, 2021 Intrinsically disordered FG-Nups line the Nuclear Pore Complex (NPC) lumen and form a selective barrier where transport of most proteins is inhibited, whereas specific transporter proteins are able to pass.
Alessio Fragasso +7 more
doaj +2 more sources
The Nuclear Pore Complex: A Target for NS3 Protease of Dengue and Zika Viruses
Viruses, 2020 During flavivirus infection, some viral proteins move to the nucleus and cellular components are relocated from the nucleus to the cytoplasm. Thus, the integrity of the main regulator of the nuclear-cytoplasmic transport, the nuclear pore complex (NPC ...
Luis Adrián De Jesús-González +11 more
doaj +2 more sources
The nuclear envelope protein TMEM209 is an integral component of the nuclear pore complex and interacts with Nup210. [PDF]
J Cell SciABSTRACT A highly curved membrane region connecting the inner and the outer nuclear membrane serves as a platform where nucleoporins with one or more transmembrane domains promote anchoring of the nuclear pore complex to the nuclear envelope.
Kohlhause D +8 more
europepmc +6 more sources
Acta Neuropathologica Communications, 2021 Nuclear pore complex injury has recently emerged as an early and significant contributor to familial and sporadic ALS disease pathogenesis. However, the molecular events leading to this pathological phenomenon characterized by the reduction of specific ...
Alyssa N. Coyne, Jeffrey D. Rothstein
doaj +1 more source
Nucleocytoplasmic Trafficking Perturbation Induced by Picornaviruses
Viruses, 2021 Picornaviruses are positive-stranded RNA viruses. Even though replication and translation of their genome take place in the cytoplasm, these viruses evolved different strategies to disturb nucleocytoplasmic trafficking of host proteins and RNA. The major
Belén Lizcano-Perret, Thomas Michiels
doaj +1 more source
Nature Communications, 2021 The involvement of nuclear pore proteins in cellular mechanosensing and metastasis is unclear. Here the authors identify that nuclear pore protein NUP210 promotes metastasis through the interaction with mechanotransducer LINC complex protein and ...
Ruhul Amin +17 more
doaj +1 more source