Results 51 to 60 of about 258,200 (289)

The Structure Inventory of the Nuclear Pore Complex [PDF]

, 2018
The nuclear pore complex (NPC) is the principal gateway for molecular exchange between nucleus and cytoplasm across the nuclear envelope. Due to its sheer size of estimated 50-112 MDa and its complex buildup from about 500-1000 individual proteins, it is
Schwartz, Thomas
core   +1 more source

The NAE Pathway : autobahn to the nucleus for cell surface receptors [PDF]

, 2019
Various growth factors and full-length cell surface receptors such as EGFR are translocated from the cell surface to the nucleoplasm, baffling cell biologists to the mechanisms and functions of this process. Elevated levels of nuclear EGFR correlate with
Bard, Frederic A., Chaumet, Alexandre, Royle, Stephen J., Shah, Poonam   +3 more
core   +1 more source

Nuclear Pore Complex StructureUnplugged and Dynamic Pores [PDF]

Developmental Cell, 2004
Nuclear pore complexes (NPCs) are large protein assemblies embedded in the nuclear envelope that act as passageways for transport of molecules into and out of the nucleus. Two new studies, one in Nature Cell Biology and one in Science , offer direct evidence that the NPC is a highly dynamic structure.
openaire   +3 more sources

The effect of cell morphology on the permeability of the nuclear envelope to diffusive factors [PDF]

, 2018
A recent advance in understanding stem cell differentiation is that the cell is able to translate its morphology, i.e., roundish or spread, into a fate decision.
García González, Alberto, Jacchetti, Emanuela, Marotta, Roberto   +2 more
core   +2 more sources

Karyopherins regulate nuclear pore complex barrier and transport function [PDF]

, 2017
Nucleocytoplasmic transport is sustained by karyopherins (Kaps) and a Ran guanosine triphosphate (RanGTP) gradient that imports nuclear localization signal (NLS)–specific cargoes (NLS-cargoes) into the nucleus.
Adam, Allen, Bayliss, Bednenko, Ben-Efraim, Binlu Huang, Bischoff, Catimel, Chaillan-Huntington, Chantal Rencurel, Chook, Christie, Cingolani, Cingolani, Conti, Delphin, Eibauer, Eisele, Falces, Floer, Forwood, Forwood, Frey, Fukuhara, Grünwald, Görlich, Görlich, Görlich, Görlich, Hahn, Halder, Hough, Isgro, Kapinos, Kau, Kimura, Kopito, Kubitscheck, Kutay, Kutay, Larisa E. Kapinos, Lee, Lee, Lim, Lim, Lolodi, Lonhienne, Lowe, Lyman, Makise, Milles, Moroianu, Moroianu, Nigg, Ogawa, Paradise, Popken, Pumroy, Pyhtila, Rexach, Ribbeck, Riddick, Roderick Y.H. Lim, Rout, Sakiyama, Schoch, Stewart, Strawn, Sun, Tauchert, Timney, Tokunaga, Tu, von Appen, Vovk, Wagner, Weis, Yamada, Yang, Yang, Yoshimura, Zachariae   +81 more
core   +1 more source

Diffusion of Macromolecules across the Nuclear Pore Complex

, 2007
Nuclear pore complexes (NPCs) are very selective filters that monitor the transport between the cytoplasm and the nucleoplasm. Two models have been suggested for the plug of the NPC. They are (i) it is a reversible hydrogel or (ii) it is a polymer brush.
Alber, Alber, Ananya Debnath, Banik, Ben-Efraim, Bhattacharjee, Bickel, Cardarelli, Cardarelli, Chakrabarti, Chakrabarti, Chatterjee, Das, Doi, Elbaum, Fahrenkrog, Feldherr, Fiserova, Frey, Frey, Grünwald, Görlich, Herrman, Isgro, Isgro, Isgro, Justin Yamada, K.L. Sebastian, Kawakatsu, Keminer, Kim, Koutsioubas, Kowalczyk, Kraikvski, Kraikvski, Kubitscheck, Kustanovich, Landau, Leitenberger, Lim, Lim, Liu, Lowe, Ma, Ma, Maarel, Marcerou, Milner, Moussavi-Baygi, Moussavi-Baygi, Nielsen, Paine, Patel, Peters, Rajaraman, Rajarshi Chakrabarti, Reister, Ribbeck, Rout, Rout, Sebastian, Sebastian, Sebastian, Sprakel, Sprakel, Tabatabaei, Tran, Weise, Xu, Yang, Zilman, Zinn-Justin   +71 more
core   +1 more source

Active Nuclear Import of Membrane Proteins Revisited

Cells, 2015
It is poorly understood how membrane proteins destined for the inner nuclear membrane pass the crowded environment of the Nuclear Pore Complex (NPC). For the Saccharomyces cerevisiae proteins Src1/Heh1 and Heh2, a transport mechanism was proposed where ...
Justyna K. Laba, Anton Steen, Petra Popken, Alina Chernova, Bert Poolman, Liesbeth M. Veenhoff   +5 more
doaj   +1 more source

Random sub-diffusion and capture of genes by the nuclear pore reduces dynamics and coordinates inter-chromosomal movement

eLife, 2021
Hundreds of genes interact with the yeast nuclear pore complex (NPC), localizing at the nuclear periphery and clustering with co-regulated genes. Dynamic tracking of peripheral genes shows that they cycle on and off the NPC and that interaction with the ...
Michael Chas Sumner, Steven B Torrisi, Donna G Brickner, Jason H Brickner   +3 more
doaj   +1 more source

Modeling of the mechano-chemical behavior of the nuclear pore complex: current research and perspectives [PDF]

, 2016
Recent evidence suggests that mechanical deformation of the cell nucleus regulates the nuclear import of the transcriptional activators of genes involved in primary physiological cell responses such as stem cell differentiation. In addition, this nuclear
Garcia, B, RAIMONDI, MANUELA TERESA, RODRIGUEZ MATAS, JOSE FELIX   +2 more
core   +1 more source

Nuclear Envelope Regulation of Oncogenic Processes: Roles in Pancreatic Cancer

Epigenomes, 2018
Pancreatic cancer is an aggressive and intractable malignancy with high mortality. This is due in part to a high resistance to chemotherapeutics and radiation treatment conferred by diverse regulatory mechanisms.
Claudia C. Preston, Randolph S. Faustino   +1 more
doaj   +1 more source