Results 31 to 40 of about 258,200 (289)

Dynamic rearrangement of nucleoporins during fungal "open" mitosis [PDF]

, 2008
Mitosis in animals starts with the disassembly of the nuclear pore complexes and the breakdown of the nuclear envelope. In contrast to many fungi, the corn smut fungus Ustilago maydis also removes the nuclear envelope.
Theisen, Ulrike, Straube, Anne, Steinberg, Gero   +2 more
core   +1 more source

Caspase-mediated nuclear pore complex trimming in cell differentiation and endoplasmic reticulum stress

eLife, 2023
During apoptosis, caspases degrade 8 out of ~30 nucleoporins to irreversibly demolish the nuclear pore complex. However, for poorly understood reasons, caspases are also activated during cell differentiation.
Ukrae H Cho, Martin W Hetzer
doaj   +1 more source

Exo70-Mediated Recruitment of Nucleoporin Nup62 at the Leading Edge of Migrating Cells is Required for Cell Migration [PDF]

, 2009
Nucleoporin Nup62 localizes at the central channel of the nuclear pore complex and is essential for nucleocytoplasmic transport. Through its FG-repeat domain, Nup62 regulates nuclear pore permeability and binds nuclear transport receptors.
Bayliss, Bayliss, Bernad, Blower, Boyd, Bradford, Brown, Buss, Caswell, Cho, Clarkson, Dawlaty, De Corte, Dultz, Frey, Grindstaff, Gromley, He, Hsu, Inoue, Jeganathan, Joseph, Joseph, Kalverda, Kasper, Kawase, Kawato, Kirsh, Lee, Liu, Loiodice, Macaulay, Matunis, Melcak, Moore, Munson, Nagai, Orjalo, Oztan, Palancade, Palancade, Paschal, Pommereit, Prigent, Rabut, Rittmeyer, Rosse, Sakurai-Yageta, Schrader, Schwarz-Herion, Stewart, Taddei, Tayeb, Terry, Towbin, Van Impe, Wang, Ward, Yeaman, Zimmermann, Zuccolo, Zuo   +61 more
core   +1 more source

Viral Subversion of the Nuclear Pore Complex

Viruses, 2013
The nuclear pore complex (NPC) acts as a selective barrier between the nucleus and the cytoplasm and is responsible for mediating communication by regulating the transport of RNA and proteins. Numerous viral pathogens have evolved different mechanisms to
Valerie Le Sage, Andrew J. Mouland
doaj   +1 more source

Structure-function mapping of a heptameric module in the nuclear pore complex. [PDF]

, 2012
The nuclear pore complex (NPC) is a multiprotein assembly that serves as the sole mediator of nucleocytoplasmic exchange in eukaryotic cells. In this paper, we use an integrative approach to determine the structure of an essential component of the yeast ...
Chait, Brian T, Diaz-Avalos, Ruben, Fernandez-Martinez, Javier, Franke, Josef D, Phillips, Jeremy, Rout, Michael P, Sali, Andrej, Sekedat, Matthew D, Stokes, David L, Velazquez-Muriel, Javier, Williams, Rosemary   +10 more
core   +2 more sources

Redox-Sensitive Cysteines Confer Proximal Control of the Molecular Crowding Barrier in the Nuclear Pore

Cell Reports, 2020
Summary: The nuclear pore complex forms a highly crowded selective barrier with intrinsically disordered regions at the nuclear membrane to coordinate nucleocytoplasmic molecular communications.
Wanzhen Zhang, Ryuji Watanabe, Hide A. Konishi, Takahiro Fujiwara, Shige H. Yoshimura, Masahiro Kumeta   +5 more
doaj   +1 more source

RNA export through the nuclear pore complex is directional

Nature Communications, 2022
There is little information on export directionality of RNA passing through the nuclear pore complex in human cells. Here, the authors examine single RNA molecules in transit, to demonstrate 5’-first directionality for the export of mRNA and lncRNA.
Asaf Ashkenazy-Titelman, Mohammad Khaled Atrash, Alon Boocholez, Noa Kinor, Yaron Shav-Tal   +4 more
doaj   +1 more source

An agent-based model for mRNA export through the nuclear pore complex. [PDF]

, 2014
mRNA export from the nucleus is an essential step in the expression of every protein- coding gene in eukaryotes, but many aspects of this process remain poorly understood.
Azimi, Mohammad, Bulat, Evgeny, Mofrad, Mohammad RK, Weis, Karsten   +3 more
core   +2 more sources

Nup133 Is Required for Proper Nuclear Pore Basket Assembly and Dynamics in Embryonic Stem Cells

Cell Reports, 2018
Summary: Nup133 belongs to the Y-complex, a key component of the nuclear pore complex (NPC) scaffold. Studies on a null mutation in mice previously revealed that Nup133 is essential for embryonic development but not for mouse embryonic stem cell (mESC ...
Benoit Souquet, Ellen Freed, Alessandro Berto, Vedrana Andric, Nicolas Audugé, Bernardo Reina-San-Martin, Elizabeth Lacy, Valérie Doye   +7 more
doaj   +1 more source

Nuclear pore complex biogenesis

Current Opinion in Cell Biology, 2009
Nuclear pore complexes (NPCs) are the sole mediators of transport between the nucleus and the cytoplasm. NPCs have a life cycle: they assemble, disassemble, turnover, and age. The molecular mechanisms governing these different vital steps are beginning to emerge, suggesting key roles for the core structural scaffold of the NPC and auxiliary factors in ...
Javier, Fernandez-Martinez, Michael P, Rout   +1 more
openaire   +3 more sources